Cannabis

Hemp seeds are gaining increased recognition as a delicious and nutritious food, but few still know they have significant medicinal value as well.

This study had the objective of preparing a hempseed protein hydrolysate and investigating its hypocholesterolemic properties. The hydrolysate was prepared treating a total protein extract with pepsin. Nano HPLC-ESI-MS/MS analysis permitted identifying in total 90 peptides belonging to 33 proteins. In the range 0.1–1.0 mg/mL, it inhibited the catalytic activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCoAR) in a dose-dependent manner. HepG2 cells were treated with 0.25, 0.5, and 1.0 mg/mL of the hydrolysate. Immunoblotting detection showed increments in the protein levels of regulatory element binding proteins 2 (SREBP2), low-density lipoprotein receptor (LDLR), and HMGCoAR. However, the parallel activation of the phospho-5′-adenosine monophosphate-activated protein kinase (AMPK) pathway, produced an inactivation of HMGCoAR by phosphorylation. The functional ability of HepG2 cells to uptake extracellular LDL was raised by 50.5 ± 2.7%, 221.5 ± 1.6%, and 109 ± 3.5%, respectively, versus the control at 0.25, 0.5, and 1.0 mg/mL concentrations. Finally, also a raise of the protein level of proprotein convertase subtilisin/kexintype 9 was observed. All of these data suggest that the mechanism of action has some similarity with that of statins.

Food proteins from different sources can provide beneficial effects on human health by releasing the bioactive peptides that are integral part of their native structure. In this study, we tested the biological potential of hempseed protein hydrolysates (HPHs) obtained from hempseed cake protein isolate. The HPHs were prepared by enzyme hydrolysis using three different proteases of microbial origin: Alcalase®, Neutrase® and Protamex®. The antioxidant activity of the obtained hydrolysates was determined by oxygen radical absorbance capacity (ORAC) assay, while the proliferative effects on normal (HaCaT) and cancer (HeLa) cells were determined by the CellTiter 96® AQueous One Solution Reagent (MTS) assay. HPHs showed dose-dependent antiproliferative effects on HeLa cells and stimulatory effects on the proliferation of HaCaT cells. HPH obtained by Neutrase® (HPH-N) showed the highest antioxidant activity expressed as an ORAC value. The protective effect of HPH-N on H2O2-induced oxidative stress in normal and cancer cells was evaluated and 1 mg/mL of HPH-N significantly reduced the formation of intracellular reactive oxygen species (ROS) in both cell lines. The obtained results indicate the benefits of HPHs as potential natural antioxidants for the food industry and contribute to the growing trend of utilizing hempseed by-products.

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(2021). Hydroxycinnamic acid derivatives isolated from hempseed and their effects on central nervous system enzymes. International Journal of Food Sciences and Nutrition: Vol. 72, No. 2, pp. 184-194.

Peptide is a promising source of safe hypoglycaemics in nutraceuticals. A biocatalytic approach, isolation and purification procedures, amino acid ana…

Cannabis contains a compound that may kill brain cancers that chemotherapy and radiation can't touch, so why isn't it being used today?

(2016) Fisher et al. Current Oncology. Background Neuroblastoma (nbl) is one of the most common solid cancers in children. Prognosis in advanced nbl is still poor despite aggressive multimodality t...

Neuroblastoma () is one of the most common solid cancers in children. Prognosis in advanced is still poor despite aggressive multimodality therapy. Furthermore, survivors experience severe long-term multi-organ sequelae. Hence, the identification of ...

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Current Oncology, an international, peer-reviewed Open Access journal.

Cannabis species have been used as medicine for thousands of years; only since the 1940s has the plant not been widely available for medical use. However, an increasing number of jurisdictions are making it possible for patients to obtain the botanical for medicinal use. For the cancer patient, cann …

Cannabis species have been used as medicine for thousands of years; only since the 1940s has the plant not been widely available for medical use. However, an increasing number of jurisdictions are making it possible for patients to obtain the botanical ...

We created unique interconnected partially graphitic carbon nanosheets (10–30 nm in thickness) with high specific surface area (up to 2287 m2 g–1), significant volume fraction of mesoporosity (up to 58%), and good electrical conductivity (211–226 S m–1) from hemp bast fiber. The nanosheets are ideally suited for low (down to 0 °C) through high (100 °C) temperature ionic-liquid-based supercapacitor applications: At 0 °C and a current density of 10 A g–1, the electrode maintains a remarkable capacitance of 106 F g–1. At 20, 60, and 100 °C and an extreme current density of 100 A g–1, there is excellent capacitance retention (72–92%) with the specific capacitances being 113, 144, and 142 F g–1, respectively. These characteristics favorably place the materials on a Ragone chart providing among the best power–energy characteristics (on an active mass normalized basis) ever reported for an electrochemical capacitor: At a very high power density of 20 kW kg–1 and 20, 60, and 100 °C, the energy densities are 19, 34, and 40 Wh kg–1, respectively. Moreover the assembled supercapacitor device yields a maximum energy density of 12 Wh kg–1, which is higher than that of commercially available supercapacitors. By taking advantage of the complex multilayered structure of a hemp bast fiber precursor, such exquisite carbons were able to be achieved by simple hydrothermal carbonization combined with activation. This novel precursor-synthesis route presents a great potential for facile large-scale production of high-performance carbons for a variety of diverse applications including energy storage.

In this video, Dr. Group interviews Carl Loveday, a pioneer in the cannabis juicing industry. Carl and Dr. Group will answer all of your questions regarding the benefits of juicing raw cannabis and why it is essential to incorporate this juicing practice into your health journey. Benefits of juicing of raw cannabis include: - helps with inflammation - improves bone metabolism - helps improve cell function - reduce damage caused by free radicals To help you with your health journey we encourage you to get a copy of Carls new book "Power of Juicing with Cannabis" today! https://powerofjuicing.com To watch the uncut full version click here: https://youtu.be/hc4G72WSku0. ------ Dr. Edward Group is the founder and CEO of Global Healing Center. He is passionate about creating life-changing products and information to help you maintain a clean body and live a healthy lifestyle. Meet Dr. Group: https://www.globalhealingcenter.com/about/dr-group ------- Connect with Dr. Group on social media! http://www.facebook.com/DrEdwardGroup ------- Follow us to Live Healthy! Facebook: https://www.facebook.com/GlobalHealingCenter Instagram: https://www.instagram.com/globalhealingcenter Twitter: https://www.twitter.com/GHChealth Pinterest: https://www.pinterest.com/ghchealth ------- The statements expressed by Dr. Group, Global Healing Center and their partners are published for educational and informational purposes only and are not intended as a diagnosis, treatment, or as a substitute for professional medical advice. ------ #drgroup #globalhealingcenter #cannabis #vegan #juice ____________ - Help us Make America Healthy and FREE Again: https://medicalfreedompac.com/

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In light of recent progress toward pharmacologic interventions to treat adolescent cannabis use disorder, it is important to consider which adolescent characteristics may be associated with a favorable response to treatment. This study presents secondary analyses from a parent randomized controlled trial of N-acetylcysteine (NAC) in adolescents with cannabis use disorder. We hypothesized that high pretreatment impulsivity and medication non-adherence would be associated with reduced abstinence rates.