Cannabis

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The seed of the hemp plant (Cannabis sativa L.) has been revered as a nutritional resource in Old World Cultures. This has been confirmed by contemporary science wherein hempseed oil (HSO) was found to exhibit a desirable ratio of omega-6 and omega-3 polyunsaturated fatty acids (PUFAs) considered optimal for human nutrition. HSO also contains gamma-linoleic acid (GLA) and non-psychoactive cannabinoids, which further contribute to its’ potential bioactive properties. Herein, we present the kinetics of the thermal stability of these nutraceutical compounds in HSO, in the presence of various antioxidants (e.g. butylated hydroxytoluene, alpha-tocopherol, and ascorbyl palmitate). We focussed on oxidative changes in fatty acid profile and acidic cannabinoid stability when HSO was heated at different temperatures (25 °C to 85 °C) for upto 24 h. The fatty acid composition was evaluated using both GC/MS and 1H-NMR, and the cannabinoids profile of HSO was obtained using both HPLC-UV and HPLC/MS methods. The predicted half-life (DT50) for omega-6 and omega-3 PUFAs in HSO at 25 °C was about 3 and 5 days, respectively; while that at 85 °C was about 7 and 5 hours respectively, with respective activation energies (Ea) being 54.78 ± 2.36 and 45.02 ± 2.87 kJ/mol. Analysis of the conjugated diene hydroperoxides (CDH) and p-Anisidine value (p-AV) revealed that the addition of antioxidants significantly (p

With CBD becoming widely available, scientists are taking a closer look at CBD-drug interactions.

On Wednesday, December 14th, the DEA included a section (21 CFR Part 1308) in the Federal Register changing the language in its current drug code. In a statement from Medical Marijuana, Inc. CEO Dr. Stuart Titus, PhD, the company confirms that the new code in no way affects the Company's products or operations.

On Wednesday, December 14th, the DEA included a section (21 CFR Part 1308) in the Federal Register changing the language in its current drug code. In a statement from Medical Marijuana, Inc. CEO Dr. Stuart Titus, PhD, the company confirms that the new code in no way affects the Company's products or operations.

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The seeds of hemp (Cannabis sativa L.) have been an important source of nutrition for thousands of years in Chinese and European cultures but, nowadays, in spite of the multiple clinical evidence, which highlights their huge health-promoting properties, people are still unaware about their nutritional as well as nutraceutical benefits. Indeed, the extraordinary richness of essential polyunsaturated fatty acids is odds with oxidative stability of hemp seed by-products. This is the reason for which different and innovative extractive strategies are daily employed, as well as the preservation of antioxidant hemp seed phenols and polyphenols is claimed as a key issue to pursue. Recent insights into the phenol and cannabinoid baggage of hemp seed highlight it is an inestimable source of health promoting ingredients. This review aims to provide a detailed and updated background for research on seeds of this niche crop, pointing out the chemistry and bioactivity of their phytochemicals.

Waldo was six months old he was diagnosed with a rare form of eye cancer and was facing an uncertain future. Doctors said he had a 50 percent chance of losing his eye. Today Waldo is tumor free, an active, outgoing kid full of energy, thanks in part, his parents say, to cannabis oil.

The recent demonstration that massive scale chromosomal shattering or pulverization can occur abruptly due to errors induced by interference with the …

Multiple Sclerosis (MS), is a common autoimmune disease that affects the central nervous system. Currently, there is no cure for MS, and most treatments involve the use of immunosuppressive drugs that can have adverse effects or increased toxicity. Cannabis, commonly known as marijuana, is a product of the Cannabis sativa , and for several centuries has been used as an alternative medicine in many cultures. Cannabis sativa produces over 421 chemical compounds, including about 80 terpenophenols named phytocannabinoids, and include both psychotropic THC and non-psychoactive CBD. In the currently study, we show that a combination therapy using THC and CBD results in amelioration of EAE, an animal model of MS, by reducing hind limb paralysis, decreasing immune cellular infiltration into the brain, and mitigating the presence of inflammatory biomarkers, including gram negative bacteria-associated lipopolysaccharide (LPS). Interestingly, the gut microbiome plays an important role in immune function and studies have shown that it is altered significantly in MS patients. Inasmuch, we performed 16S rRNA sequencing on experimental groups to investigate the gut microbiome composition after using a combination of THC and CBD compared to disease controls. Interestingly, we found that EAE mice showed increase in the mucin degrading bacterial species, Akkermansia municiphila , which was significantly reduced in disease mice treated with THC+CBD. Collectively, our data suggests that THC+CBD can ameliorate EAE by preventing accumulation of mucin-degrading bacteria that would lead to increased gut microbial dysbiosis.

The French beekeeper has self-medicated with cannabis since a very early age and he defines himself as someone that is passionate about nature and training all kinds o...

Medical marijuana is having a positive impact on the bottom line of Medicare's prescription drug benefit program in states that have legalized its use for medicinal purposes, according to new research.The savings, due to lower prescription drug use, were estimated to be $165.2 million in 2013, a year when 17 states and the District of Columbia had implemented medical marijuana laws.

(2017). Bioactive spirans and other constituents from the leaves of Cannabis sativa f. sativa. Journal of Asian Natural Products Research: Vol. 19, No. 8, pp. 793-802.

Walacea is crowdfunding a clinical trial in 30 patients investigating cannabis in the treatment of cancer. Cannabinoids have anti-cancer activity.

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Cannabidiol (CBD), a major constituent of Cannabis, has been shown to be a powerful anti-inflammatory and anti-anxiety drug, without exerting a psychotropic effect. However, when given either intraperitoneally or orally as a purified product, a bell-shaped dose-response was observed, which limits its clinical use. In the present study, we have studied in mice the anti-inflammatory and anti-nociceptive activities of standardized plant extracts derived from the Cannabis sativa L., clone 202, which is highly enriched in CBD and hardly contains any psychoactive ingredients. In stark contrast to purified CBD, the clone 202 extract, when given either intraperitoneally or orally, provided a clear correlation between the anti-inflammatory and anti-nociceptive responses and the dose, with increasing responses upon increasing doses, which makes this plant medicine ideal for clinical uses. The clone 202 extract reduced zymosan-induced paw swelling and pain in mice, and prevented TNFα production in vivo. It is likely that other components in the extract synergize with CBD to achieve the desired anti-inflammatory action that may contribute to overcoming the bell-shaped dose-response of purified CBD. We therefore propose that Cannabis clone 202 (Avidekel) extract is superior over CBD for the treatment of inflammatory conditions.

Picking the seeds and stems out of the Bible.

The biggest barrier to reducing toxic pesticides in cannabis is, not surprisingly, the cannabis industry itself. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ For more on the link between the tobacco and marijuana industries, check out: Will Cannabis Turn Into Big Tobacco? (http://nutritionfacts.org/video/will-cannabis-turn-into-big-tobacco) I have a whole catalogue of marijuana videos and I’ve got more to come. Here are the ones that are already up in case you missed any: • The Institute of Medicine Report on the Health Effects of Marijuana (http://nutritionfacts.org/video/The-Institute-of-Medicine-Report-on-the-Health-Effects-of-Marijuana) • Researching the Health Effects of Marijuana (http://nutritionfacts.org/video/Researching-the-Health-Effects-of-Marijuana) • Is Marijuana Addictive? (http://nutritionfacts.org/video/Is-Marijuana-Addictive) • Does Marijuana Cause Health Problems? (http://nutritionfacts.org/video/Does-Marijuana-Cause-Health-Problems) • Does Marijuana Cause Permanent Brain Damage in Teens? (http://nutritionfacts.org/video/Does-Marijuana-Cause-Permanent-Brain-Damage-in-Teens) • Does Marijuana Cause Permanent Brain Damage in Adults? (http://nutritionfacts.org/video/Does-Marijuana-Cause-Permanent-Brain-Damage-in-Adults) • Marijuana Legalization and the Opioid Epidemic (http://nutritionfacts.org/video/Marijuana-Legalization-and-the-Opioid-Epidemic) • Effects of Smoking Marijuana on the Lungs (http://nutritionfacts.org/video/effects-of-smoking-marijuana-on-the-lungs) • Smoking Marijuana vs. Using a Cannabis Vaporizer (http://nutritionfacts.org/video/Smoking-Marijuana-vs-Using-a-Cannabis-Vaporizer) • Does Marijuana Cause Lung Cancer? (http://nutritionfacts.org/video/does-marijuana-cause-lung-cancer) • Can Cannabis Cure Cancer? (http://nutritionfacts.org/video/can-cannabis-cure-cancer) • Are Cannabis Edibles Safe? (http://nutritionfacts.org/video/are-cannabis-edibles-safe) More tobacco industry parallels can be found in Big Food Using the Tobacco Industry Playbook (http://nutritionfacts.org/video/big-food-using-the-tobacco-industry-playbook), American Medical Association Complicity with Big Tobacco (https://nutritionfacts.org/video/american-medical-association-complicity-big-tobacco/), and How Smoking in 1959 is Like Eating in 2019 (http://nutritionfacts.org/video/how-smoking-in-the-50s-is-like-eating-today). Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/pesticides-in-marijuana and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/pesticides-in-marijuana. You’ll also find a transcript and acknowledgments for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Captions for this video are available in several languages. To find yours, click on the settings wheel on the lower-right of the video and then "Subtitles/CC." Do you have feedback about the translations in this video? Please share it here along with the title of the video and language: https://nutritionfacts.zendesk.com/hc/requests/new To view the subtitles in transcript format, click on the ellipsis button below the video, choose "Open transcript", and select the language you'd like to view them in. Image credit: Andrea / Adobe Stock photos http://www.NutritionFacts.org • Subscribe: http://www.NutritionFacts.org/subscribe • Donate: http://www.NutritionFacts.org/donate • HOW NOT TO DIE: http://nutritionfacts.org/book • Facebook: http://www.facebook.com/NutritionFacts.org • Twitter: http://www.twitter.com/nutrition_facts • Instagram: http://instagram.com/nutrition_facts_org/ • Podcast : http://nutritionfacts.org/audio/

Cannabis is the most widely used illicit drug worldwide. Regular cannabis use has been associated with a range of acute and chronic mental health problems, such as anxiety, depression, psychotic symptoms and neurocognitive impairments and their neural mechanisms need to be examined. This review summ …