Biome

A new literature review suggests that nutrition and diet have a profound impact on the microbial composition of the gut.

Fiber isn’t the only thing our good gut bacteria can eat; starch can also act as a prebiotic. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ This is a follow-up to my video Is the Fiber Theory Wrong?(http://nutritionfacts.org/video/is-the-fiber-theory-wrong) What is this butyrate stuff of which I speak? See: • Bowel Wars: Hydrogen Sulfide vs. Butyrate (http://nutritionfacts.org/video/bowel-wars-hydrogen-sulfide-vs-butyrate/) • Prebiotics: Tending Our Inner Garden (http://nutritionfacts.org/video/prebiotics-tending-our-inner-garden) • Treating Ulcerative Colitis with Diet (http://nutritionfacts.org/video/treating-ulcerative-colitis-with-diet) For videos on optimizing your gut flora, see: • Microbiome: The Inside Story (http://nutritionfacts.org/video/microbiome-the-inside-story) • What’s Your Gut Microbiome Enterotype?http://nutritionfacts.org/video/whats-your-gut-microbiome-enterotype • How to Change Your Enterotype (http://nutritionfacts.org/video/how-to-change-your-enterotype/) More on preventing colon cancer in: • Starving Cancer with Methionine Restriction (http://nutritionfacts.org/video/starving-cancer-with-methionine-restriction/) • Stool pH and Colon Cancer (http://nutritionfacts.org/video/stool-ph-and-colon-cancer/) • Solving a Colon Cancer Mystery (http://nutritionfacts.org/video/solving-a-colon-cancer-mystery/) If you’re eating healthy do you need a colonoscopy? Find out in Should We All Get Colonoscopies Starting at Age 50? (http://nutritionfacts.org/video/should-we-all-get-colonoscopies-starting-at-age-50). When regular starches are cooked and then cooled, some of the starch recrystallizes into resistant starch. For this reason, pasta salad can be healthier than hot pasta and potato salad healthier than a baked potato. Find out more in my next video Getting Starch to Take the Path of Most Resistance (http://nutritionfacts.org/video/Getting-starch-to-take-the-path-of-most-resistance). Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/resistant-starch-and-colon-cancer/ and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/resistant-starch-and-colon-cancer/. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image Credit: Ed Uthman via flickr. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org #coloncancer #hownottodie #drgreger

(2016). Resistant starch reduces colonic and urinary p-cresol in rats fed a tyrosine-supplemented diet, whereas konjac mannan does not. Bioscience, Biotechnology, and Biochemistry: Vol. 80, No. 10, pp. 1995-2000.

Science says eating just one meal per day can improve your health. Learn more at https://highintensityhealth.com/OMAD ----- Access the Show Notes & Download the Audio: http://highintensityhealth.com/digestion-gut-microbiome-probiotics-prebiotics-russell-jaffe-md-phd-ccn/ Key Points: 15:15 Antibiotics Lay Waste to our Microbiome. This is well explained in When Antibiotics Fail: Restoring the Ecology of the Body, a book by Mark Lappe’ and in Michael Schmidt’s work. You need to work intensively replenishing every day for 3 to 6 months after antibiotic exposure using multiple healthy organisms, fermented food and active supplements. Dr. Jaffe uses the power of billions of live CFU, colony forming units, in human implantable strains. Live bugs work and dead bugs don’t. 16:43 We Can Make Our Own: We can make our own prebiotic foods with high fiber to feed the good bugs. We can take in enough probiotic organisms to replenish those expended from stress and toxin exposure, and symbiotic foods, nutrients like recycled glutamine, which helps repair the digestive tract. Prebiotics, probiotics and symbiotics form a triad. 17:33 Renaissance of Proactive Primary Prevention: For the past 3 years, throughout the world there have been public health initiatives to get more prebiotic high fiber, probiotic organisms, and symbiotics into our diets. The lining of the intestinal tract is one of the most vulnerable places in the body. It replaces itself about every 3 days. A healthy person’s digestive tract, if laid out flat, would be as large as a tennis court. Most American adults suffer from atrophy of their digestive tract because they have not been nourishing and nurturing it. This means that they only have a few square feet. The good news is that this can nearly always be rehabilitated. 18:57 The Age Myth: It is a lie that once we begin to decline with age that it can be slowed and symptoms can be suppressed, but the decline is irreversible and inescapable. The age myth is about the proportion of unhealthy people at certain stages of life. Dr. Jaffe has tested groups of 90 to 100 year olds and healthy 20 to 30 year olds, drawing their blood, culturing their white cells, culturing muscles and other cells, and the groups are indistinguishable from each other. 20:48 A Detailed Description of Digestion: Digestion begins with your eyes. They tell your gut and your brain, what you will be consuming. As we chew, small bits of food escape through the mucosa to inform the brain and the gut as to what digestive juices will be needed for this meal. The stomach churns and produces acid. People with ulcers have low stomach acid and healthy people have lots of stomach acid. Proton pump inhibitors are prescribed all the time. Often, if you believe they will work, they will work just slightly better than placebos. When you inhibit stomach acid production, you set up a chain of events of maldigestion, often with the sensitization of the immune system. It is essential that we have an amino acid called histadine that donates the proton, the acid that keeps the stomach acidic so that pepsin, the enzyme that loves to be in that acid environment, begins to open the food particles, especially the proteins and the concentrated foods. The acid in the chyme, which is the stuff that comes out of the stomach and is delivered to the small intestine, triggers a bicarbonate and digestive enzyme release from the pancreas. . We meet the bicarbonate and digestive enzymes that pour out of the pancreas to neutralize the stomach acid and begin the next phase. At a small duct, bile comes in to emulsify fats, bringing fat soluble vitamins and nutrients into the body. For the next 20 feet, nutrients are taken up selectively. Then it is on to the large intestine, which should not have digestive remnants. By the time we get to the ileocecal valve that separates the small intestine from the large, the food should be broken down to non-immune reactive building blocks that get assimilated. There should be enough fiber to bind toxins and remove them from the body. These toxins are putrescine, cadaverine, and other polyamines, which can form when digestive transit time is longer than the healthy 12 to 18 hours. 25:17 Digestive Transit Time: Typical Americans have a 72 hour to 144 hour transit time from entrance to exit. If you are, you will want to increase the fiber in your diet, you eat foods that you can digest, assimilate and eliminate without immune burden, if you have some sense of portion control, so we do not overwhelm the body. Only about 1 in 20 Americans, or about 5% of our population, has a healthy transit time of 12 to 18 hours and a healthy digestion. Maldigestion, dysbiosis, inflammatory atrophy and enteropathy of the digestive mechanisms is at epidemic proportions and has been for many decades. These digestive disorders are most often the cause of chronic degenerative autoimmune and inflammatory conditions.

Background Mortality from chronic liver disease is rising exponentially. The liver is intimately linked to the gut via the portal vein, and exposure to gut microbiota and their metabolites transloca...

The human intestinal microbiome is thought to influence tumor development and progression in the gastrointestinal tract by various mechanisms. Therefore, by better understanding the microbiome in eso...

An extraordinary Facebook Live with Dr. Mike Hoaglin, MD from uBiome. You’ll understand: ✓ What the microbiome is and why it’s a huge clue into your health status. ✓ What it impacts and how you can change your microbiome and change the course of your health. ✓ The best evidenced-based way to test your microbiome. ✓ What your weight has to do with your microbiome. ✓ The number one change you can make right now to alter your microbiome, and so much more...

Reported values in the literature on the number of cells in the body differ by orders of magnitude and are very seldom supported by any measurements or calculations. Here, we integrate the most up-to-date information on the number of human and bacterial ...

Chronic kidney disease results in disruption of the intestinal epithelial barrier as well as profound changes in the gut microbial flora. These events…

At first glance, fecal microbiota transplantation (FMT) appears to be a far-fetched procedure devised as a slapstick plot for a sit-com series. However, this innovative technique may revolutionize the future of medical treatments for a host of maladies including autoimmune and allergic diseases as well as autism spectrum disorder.

Thanks to the Human Microbiome Project, we know that we are home to trillions of microbes, the largest number of which are found in our gut. And as in agriculture, diversity tends toward health

Background Type II diabetes is a chronic health condition which is associated with skin conditions including chronic foot ulcers and an increased incidence of skin infections. The skin microbiome is thought to play important roles in skin defence and immune functioning. Diabetes affects the skin environment, and this may perturb skin microbiome with possible implications for skin infections and wound healing. This study examines the skin and wound microbiome in type II diabetes. Methods Eight type II diabetic subjects with chronic foot ulcers were followed over a time course of 10 weeks, sampling from both foot skin (swabs) and wounds (swabs and debrided tissue) every two weeks. A control group of eight control subjects was also followed over 10 weeks, and skin swabs collected from the foot skin every two weeks. Samples were processed for DNA and subject to 16S rRNA gene PCR and sequencing of the V4 region. Results The diabetic skin microbiome was significantly less diverse than control skin. Community composition was also significantly different between diabetic and control skin, however the most abundant taxa were similar between groups, with differences driven by very low abundant members of the skin communities. Chronic wounds tended to be dominated by the most abundant skin Staphylococcus, while other abundant wound taxa differed by patient. No significant correlations were found between wound duration or healing status and the abundance of any particular taxa. Discussion The major difference observed in this study of the skin microbiome associated with diabetes was a significant reduction in diversity. The long-term effects of reduced diversity are not yet well understood, but are often associated with disease conditions.

The vaginal microbiome plays an important role in maternal and neonatal health. Imbalances in this microbiota (dysbiosis) during pregnancy are associated with negative reproductive outcomes, such as pregnancy loss and preterm birth, but the underlying mechanisms remain poorly understood. Consequentl …

The future of probiotics is here

The last thing anyone wants during a stay in the hospital is a hospital-acquired infection. Nosocomial infections, as they are called, are on the rise as more pathogens become resistant to drugs currently available.

Abundant clinical, epidemiological, imaging, genetic, molecular, and pathophysiological data together indicate that there occur an unusual inflammatory reaction and a disruption of the innate-immune signaling system in Alzheimer’s disease (AD) brain. Despite many years of intense study, the origin and molecular mechanics of these AD-relevant pathogenic signals are still not well understood. Here, we provide evidence that an intensely pro-inflammatory bacterial lipopolysaccharide (LPS), part of a complex mixture of pro-inflammatory neurotoxins arising from abundant Gram-negative bacilli of the human gastrointestinal (GI) tract, are abundant in AD-affected brain neocortex and hippocampus. For the first time, we provide evidence that LPS immunohistochemical signals appear to aggregate in clumps in the parenchyma in control brains, and in AD, about 75% of anti-LPS signals were clustered around the periphery of DAPI-stained nuclei. As LPS is an abundant secretory product of Gram-negative bacilli resident in the human GI-tract, these observations suggest (i) that a major source of pro-inflammatory signals in AD brain may originate from internally derived noxious exudates of the GI-tract microbiome; (ii) that due to aging, vascular deficits or degenerative disease these neurotoxic molecules may “leak” into the systemic circulation, cerebral vasculature, and on into the brain; and (iii) that this internal source of microbiome-derived neurotoxins may play a particularly strong role...

A simple swab to transfer vaginal microbes from a mother to her C-section-delivered newborn can alter the baby's microbial makeup (microbiome) in a way that more closely resembles the microbiome of a vaginally delivered baby, a small pilot study has demonstrated.

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Fucoidan is a functional food that possesses various biological activities. This study aims to determine the effects of fucoidan from Undaria pinnatif…

In one of the largest microbiota studies conducted in humans, researchers have shown a potential link between healthy aging and a healthy gut.

Long-term survival of lung transplant recipients (LTRs) is limited by the occurrence of bronchiolitis obliterans syndrome (BOS). Recent evidence suggests a role for microbiome alterations in the occurrence of BOS, although the precise mechanisms are unclear. In this study we evaluated the relationship between the airway microbiome and distinct subsets of immunoregulatory myeloid-derived suppressor cells (MDSCs) in LTRs.

The incidence of diabetes mellitus is rapidly increasing throughout the world. Although the exact cause of the disease is not fully clear, perhaps, genetics, ethnic origin, obesity, age, and lifestyle are considered as few of many contributory factors for the disease pathogenesis. In recent years, the disease progression is particularly linked with functional and taxonomic alterations in the gastrointestinal tract microbiome. A change in microbial diversity, referred as microbial dysbiosis, alters the gut fermentation profile and intestinal wall integrity and causes metabolic endotoxemia, low-grade inflammation, autoimmunity, and other affiliated metabolic disorders. This article aims to summarize the role of the gut microbiome in the pathogenesis of diabetes. Additionally, we summarize gut microbial dysbiosis in preclinical and clinical diabetes cases reported in literature in the recent years.

Chinese Medical Journal, a publication of Chinese Medical Association, is a peer-reviewed online journal with semi-monthly print on demand compilation of issues published. The journal's full text is available online at http://www.cmj.org. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository.

Do Antibiotics Cause Celiac Disease? Some researchers say yes they can. Especially in those with genetic susceptibility to gluten sensitivity. Antibiotics cause a yeast overgrowth, and emerging research shows that yeast - AKA candida, can create a protein that mimics gluten, causing an intestinal reaction leading to the development of celiac disease. To connect with Dr. Osborne visit: Facebook: https://www.facebook.com/DoctorPeterO... Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.

Could Monsanto's glyphosate-based herbicide Roundup be leading to the overgrowth of deadly bacteria in animals and humans consuming genetically-modified food contaminated with it?

Scientists show how a specific strain of microbes helps control glucose homeostasis in mice. In the future, this could mean more targeted and powerful probiotics in humans.

Bacteria that live in the gut have been used to reverse obesity and Type-2 diabetes, animal studies show.