Biome

Omega-3 fatty acids may influence human physiological parameters in part by affecting the gut microbiome. The aim of this study was to investigate the links between omega-3 fatty acids, gut microbiome diversity and composition and faecal metabolomic profiles ...

AOBiome is a world-leading clinical-stage microbiome company focusing on research and development of therapeutics for inflammatory conditions, central nervous system disorders and other diseases. Our proprietary product candidates harness a strain of class-defining, auto-regulating Ammonia Oxidizing Bacteria, or AOB, a human commensal with well-understood and well-characterized biochemical properties that are critical to human health. We believe that the application of AOB has the potential to restore critical biological and biochemical processes through the symbiotic relationship between humans and this naturally-existing bacteria to address significant clinical need at various stages of disease. We have six ongoing clinical programs in acne vulgaris, or acne, atopic dermatitis, or eczema, rosacea, allergic rhinitis, migraine and hypertension, and multiple ongoing preclinical programs, including ones addressing pulmonary and gastrointestinal disorders.

Fighting infection with conventional antibiotics is becoming a hopeless affair. The CDC recently warned these drugs are useless in combatting deadly “super germs.” So what can one do? Your kitchen holds the key.

Multiple Sclerosis (MS), is a common autoimmune disease that affects the central nervous system. Currently, there is no cure for MS, and most treatments involve the use of immunosuppressive drugs that can have adverse effects or increased toxicity. Cannabis, commonly known as marijuana, is a product of the Cannabis sativa , and for several centuries has been used as an alternative medicine in many cultures. Cannabis sativa produces over 421 chemical compounds, including about 80 terpenophenols named phytocannabinoids, and include both psychotropic THC and non-psychoactive CBD. In the currently study, we show that a combination therapy using THC and CBD results in amelioration of EAE, an animal model of MS, by reducing hind limb paralysis, decreasing immune cellular infiltration into the brain, and mitigating the presence of inflammatory biomarkers, including gram negative bacteria-associated lipopolysaccharide (LPS). Interestingly, the gut microbiome plays an important role in immune function and studies have shown that it is altered significantly in MS patients. Inasmuch, we performed 16S rRNA sequencing on experimental groups to investigate the gut microbiome composition after using a combination of THC and CBD compared to disease controls. Interestingly, we found that EAE mice showed increase in the mucin degrading bacterial species, Akkermansia municiphila , which was significantly reduced in disease mice treated with THC+CBD. Collectively, our data suggests that THC+CBD can ameliorate EAE by preventing accumulation of mucin-degrading bacteria that would lead to increased gut microbial dysbiosis.

Why does our immune system confuse unhealthy diets with dysbiosis—an overrun of bad bacteria in our colon? Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ For more on gut health and microbiome, check out the playlist: https://www.youtube.com/playlist?list=PL5TLzNi5fYd9bVwe5wDtBA3miV7rsANY0 Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/flashback-friday-prebiotics-tending-our-inner-garden and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/flashback-friday-prebiotics-tending-our-inner-garden. You’ll also find a transcript and acknowledgments for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Captions for this video are available in several languages. To find yours, click on the settings wheel on the lower-right of the video and then "Subtitles/CC." Do you have feedback about the translations in this video? Please share it here along with the title of the video and language: https://nutritionfacts.zendesk.com/hc/requests/new To view the subtitles in transcript format, click on the ellipsis button below the video, choose "Open transcript", and select the language you'd like to view them in. Image Credit: ZEISS Microscopy via Flickr. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Antibiotics may be linked to a serious disruption in brain function, called delirium, and other brain problems, more than previously thought, according to a new article. Delirium causes mental confusion that may be accompanied by hallucinations and agitation. Medications are often the cause of delirium, but antibiotics are not necessarily the first medications doctors may suspect.

Rather than haphazardly buying probiotics off the shelf, customize your selection this cold and flu season with evidence-based strains proven to boost immunity

Species compositions of gut microbiomes impact host health [1, 2, 3], but the processes determining these compositions are largely unknown. An unexpla…

Intestinal bacteria that can boost bravery or trigger multiple sclerosis: An increasing body of research results confirms the importance of the “gut-brain axis” for neurology and indicates that the triggers for a number of neurological diseases may be located in the digestive tract.

ReferenceKaramali M, Nasiri N, Shavazi NT, et al. The effects of synbiotic supplementation on pregnancy outcomes in gestational diabetes. Probiotics Antimicrob Proteins (published online ahead of print August 7, 2017).

Research indicates that the ancient spice turmeric may help to mitigate the growing threat of antibiotic resistant infections that the CDC estimates will take 23,000 U.S. lives each year.

Probiotic supplements protected female mice from the loss of bone density that occurs after having their ovaries removed, researchers have shown. The findings suggest that probiotic bacteria may have potential as an inexpensive treatment for post-menopausal osteoporosis.

Revolutionary research illuminates that a new frontier of personalized medicine lies in the virome. Rather than harbingers of disease, viruses are intrinsic to immune modulation and to disease susceptibility.

In certain medical conditions, probiotic supplements may actually make things worse. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ Support NutritionFacts.org with a donation at http://www.NutritionFacts.org/donate. This is a link to the video I alluded to: Preventing the Common Cold with Probiotics? (http://nutritionfacts.org/video/preventing-the-common-cold-with-probiotics). I also talk about the potential benefits in my videos Preventing and Treating Diarrhea with Probiotics (https://nutritionfacts.org/video/preventing-and-treating-diarrhea-with-probiotics/) and Gut Feelings: Probiotics and Mental Health (https://nutritionfacts.org/video/gut-feelings-probiotics-and-mental-health/). Perhaps it would be safer and more effective to instead focus on fostering the growth of the good bacteria with have by feeding them prebiotics (fiber and resistant starch): • Prebiotics: Tending Our Inner Garden (https://nutritionfacts.org/video/prebiotics-tending-our-inner-garden) • Boosting Good Bacteria in the Colon Without Probiotics (https://nutritionfacts.org/video/boosting-good-bacteria-in-the-colon-without-probiotics/) • Resistant Starch and Colon Cancer (https://nutritionfacts.org/video/resistant-starch-colon-cancer) • Gut Dysbiosis - Starving Our Microbial Self (https://nutritionfacts.org/video/is-obesity-infectious) • How to Become a Fecal Transplant Super Donor (https://nutritionfacts.org/video/How-to-Become-a-Fecal-Transplant-Super-Donor) • Microbiome: We Are What They Eat (https://nutritionfacts.org/video/Microbiome-We-Are-What-They-Eat) Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/culture-shock-questioning-the-efficacy-and-safety-of-probiotics and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/culture-shock-questioning-the-efficacy-and-safety-of-probiotics. You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Captions for this video are available in several languages. To find yours, click on the settings wheel on the lower-right of the video and then "Subtitles/CC." Do you have feedback about the translations in this video? Please share it here along with the title of the video and language: https://nutritionfacts.zendesk.com/hc/requests/new To view the subtitles in transcript format, click on the ellipsis button below the video, choose "Open transcript", and select the language you'd like to view them in. Icons created by Laymik, Tinashe Mugayi, Nikita Kozin, and Tomas Knopp from The Noun Project. Image credit: Kristina DeMuth https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Background and Aim Acid suppressive agents including proton pump inhibitors (PPIs) are used as first-line treatment for various acid-related gastrointestinal disorders. Although known to profoundly ...

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Similar to the use of GcMAF, degalactosylated/desialylated bovine colostrum can be used as a potential macrophage activator for various immunotherapies.

Background Urbanization is associated with an increased risk for a number of diseases, including obesity, diabetes, and cancer, which all also show associations with the microbiome. While microbial community composition has been shown to vary across continents and in traditional versus Westernized societies, few studies have examined urban-rural differences in neighboring communities within a single country undergoing rapid urbanization. In this study, we compared the gut microbiome, plasma metabolome, dietary habits, and health biomarkers of rural and urban people from a single Chinese province. Results We identified significant differences in the microbiota and microbiota-related plasma metabolites in rural versus recently urban subjects from the Hunan province of China. Microbes with higher relative abundance in Chinese urban samples have been associated with disease in other studies and were substantially more prevalent in the Human Microbiome Project cohort of American subjects. Furthermore, using whole metagenome sequencing, we found that urbanization was associated with a loss of microbial diversity and changes in the relative abundances of Viruses, Archaea, and Bacteria. Gene diversity, however, increased with urbanization, along with the proportion of reads associated with antibiotic resistance and virulence, which were strongly correlated with the presence of Escherichia and Shigella. Conclusions Our data suggest that urbanization has produced convergent evolution of the gut microbial composition in American and urban Chinese populations, resulting in similar compositional patterns of abundant microbes through similar lifestyles on different continents, including a loss of potentially beneficial bacteria and an increase in potentially harmful genes via increased relative abundance of Escherichia and Shigella.

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A new literature review suggests that nutrition and diet have a profound impact on the microbial composition of the gut.

Fiber isn’t the only thing our good gut bacteria can eat; starch can also act as a prebiotic. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ This is a follow-up to my video Is the Fiber Theory Wrong?(http://nutritionfacts.org/video/is-the-fiber-theory-wrong) What is this butyrate stuff of which I speak? See: • Bowel Wars: Hydrogen Sulfide vs. Butyrate (http://nutritionfacts.org/video/bowel-wars-hydrogen-sulfide-vs-butyrate/) • Prebiotics: Tending Our Inner Garden (http://nutritionfacts.org/video/prebiotics-tending-our-inner-garden) • Treating Ulcerative Colitis with Diet (http://nutritionfacts.org/video/treating-ulcerative-colitis-with-diet) For videos on optimizing your gut flora, see: • Microbiome: The Inside Story (http://nutritionfacts.org/video/microbiome-the-inside-story) • What’s Your Gut Microbiome Enterotype?http://nutritionfacts.org/video/whats-your-gut-microbiome-enterotype • How to Change Your Enterotype (http://nutritionfacts.org/video/how-to-change-your-enterotype/) More on preventing colon cancer in: • Starving Cancer with Methionine Restriction (http://nutritionfacts.org/video/starving-cancer-with-methionine-restriction/) • Stool pH and Colon Cancer (http://nutritionfacts.org/video/stool-ph-and-colon-cancer/) • Solving a Colon Cancer Mystery (http://nutritionfacts.org/video/solving-a-colon-cancer-mystery/) If you’re eating healthy do you need a colonoscopy? Find out in Should We All Get Colonoscopies Starting at Age 50? (http://nutritionfacts.org/video/should-we-all-get-colonoscopies-starting-at-age-50). When regular starches are cooked and then cooled, some of the starch recrystallizes into resistant starch. For this reason, pasta salad can be healthier than hot pasta and potato salad healthier than a baked potato. Find out more in my next video Getting Starch to Take the Path of Most Resistance (http://nutritionfacts.org/video/Getting-starch-to-take-the-path-of-most-resistance). Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/resistant-starch-and-colon-cancer/ and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/resistant-starch-and-colon-cancer/. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image Credit: Ed Uthman via flickr. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org #coloncancer #hownottodie #drgreger