Allergology International is the official journal of the Japanese Society of Allergology and publishes original papers dealing with the etiology, diagnosis and treatment of allergic and related...

Colorectal cancer is the second-leading cause of cancer-related deaths in the United States and fourth-leading cause of cancer-related deaths worldwide. While cancer is largely considered to be a disease of genetic and environmental factors, increasing evidence has demonstrated a role for the microbiota (the microorganisms associated with the human body) in shaping inflammatory environments and promoting tumor growth and spread. Herein, we discuss both human data from meta'omics analyses and data from mechanistic studies in cell culture and animal models that support specific bacterial agents as potentiators of tumorigenesis—including Fusobacterium nucleatum, enterotoxigenic Bacteroides fragilis, and colibactin-producing Escherichia coli. Further, we consider how microbes can be used in diagnosing colorectal cancer and manipulating the tumor environment to encourage better patient outcomes in response to immunotherapy treatments.

New research is helping to tease out the mechanics of how the gut microbiome communicates with the cells of its host to switch genes on and off. The upshot of the study, another indictment of the so-called Western diet (high in saturated fats, sugar and red meat), reveals how the metabolites produced by the bacteria in the stomach chemically communicate with cells, including cells far beyond the colon, to dictate gene expression and health in its host.

This guy is saving lives with his poop, and maybe you can, too.

The healing powers of honey have been known for thousands of years. Now a researchers has discovered a powerful link between a medicinal type of honey and the destruction of a fungus that can cause blindness or even death.

The reason egg consumption is associated with elevated cancer risk may be the TMAO, considered the “smoking gun” of microbiome-disease interactions. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ What did the egg industry do in response to this information? Distort the scientific record of course! See Egg Industry Response to Choline and TMAO (http://nutritionfacts.org/video/egg-industry-response-to-choline-and-tmao). This is not the first time the egg industry has been caught in the act. See, for example: • Who Says Eggs Aren’t Healthy or Safe? (http://nutritionfacts.org/video/who-says-eggs-arent-healthy-or-safe) • Does Cholesterol Size Matter? (http://nutritionfacts.org/video/does-cholesterol-size-matter) • How the Egg Board Designs Misleading Studies (http://nutritionfacts.org/video/how-the-egg-board-designs-misleading-studies/) • Debunking Egg Industry Myths (http://nutritionfacts.org/video/debunking-egg-industry-myths) • Eggs and Cholesterol: Patently False and Misleading Claims (http://nutritionfacts.org/video/eggs-and-cholesterol-patently-false-and-misleading-claims) For background on TMAO see my original coverage in Carnitine, Choline, Cancer, and Cholesterol: The TMAO Connection (http://nutritionfacts.org/video/carnitine-choline-cancer-and-cholesterol-the-tmao-connection). This is all part of the microbiome revolution in medicine, the underappreciated role our gut flora play in our health. For more, see: • Stool pH and Colon Cancer (http://nutritionfacts.org/video/stool-ph-and-colon-cancer) • Bowel Wars: Hydrogen Sulfide vs. Butyrate (http://nutritionfacts.org/video/bowel-wars-hydrogen-sulfide-vs-butyrate) • Putrefying Protein & “Toxifying” Enzymes (http://nutritionfacts.org/video/putrefying-protein-and-toxifying-enzymes) • Microbiome: The Inside Story (http://nutritionfacts.org/video/microbiome-the-inside-story) • Prebiotics: Tending our Inner Garden (http://nutritionfacts.org/video/prebiotics-tending-our-inner-garden) • What’s your Gut Microbiome Enterotype? (http://nutritionfacts.org/video/whats-your-gut-microbiome-enterotype) • How to Change your Enterotype (http://nutritionfacts.org/video/how-to-change-your-enterotype) • Paleopoo: What We Can Learn from Fossilized Feces (http://nutritionfacts.org/video/paleopoo-what-we-can-learn-from-fossilized-feces) • Gut Dysbiosis: Starving Our Microbial Self (http://nutritionfacts.org/video/gut-dysbiosis-starving-microbial-self) • Egg Industry Response to Choline & TMAO (http://nutritionfacts.org/video/egg-industry-response-to-choline-and-tmao) • Is Obesity Infectious? (http://nutritionfacts.org/video/is-obesity-infectious) • How to Develop a Healthy Gut Ecosystem (http://nutritionfacts.org/video/how-to-develop-a-healthy-gut-ecosystem) • How to Become a Fecal Transplant Super Donor (http://nutritionfacts.org/video/how-to-become-a-fecal-transplant-super-donor) Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/how-our-gut-bacteria-can-use-eggs-to-accelerate-cancer and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/how-our-gut-bacteria-can-use-eggs-to-accelerate-cancer. You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image credit: Praveen via pixabay. Image has been modified. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

A study sheds new light on the connection between the gut and the brain, untangling the complex interplay that allows the byproducts of microorganisms living in the gut to influence the progression of neurodegenerative diseases.

What’s more important: probiotics or prebiotics? And where best to get them? Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ We have shifted to a new look for our videos, pulling in motion graphics design specialists to help mix things up. This one was done by Avocado Video’s (http://www.avocadovideo.com/) Lucas Kavanagh (http://www.lucas.fyi/) and Jesse Lupini (http://www.jesselupini.com/). Lucus is a scientist passionate about finding innovative ways to communicate intricate concepts who says he’s “excited to be working with NutritionFacts to help make peer-reviewed health information accessible to anyone.” Jesse is a director and producer with a love for science and education who say she’s “thrilled to be working with NutritionFacts, a beacon of science-driven health information in a sea of online nutritional voodoo and pseudo-science.” The microbiome is one of the most exciting research areas in medicine these days. For more, see for example: • Bowel Wars: Hydrogen Sulfide vs. Butyrate (http://nutritionfacts.org/video/bowel-wars-hydrogen-sulfide-vs-butyrate/) • Putrefying Protein & “Toxifying” Enzymes (http://nutritionfacts.org/video/putrefying-protein-and-toxifying-enzymes/) • Microbiome: The Inside Story (http://nutritionfacts.org/video/microbiome-the-inside-story/) • What’s your Gut Microbiome Enterotype? (http://nutritionfacts.org/video/whats-your-gut-microbiome-enterotype/) • How to Change your Enterotype (http://nutritionfacts.org/video/how-to-change-your-enterotype/) • Paleopoo: What We Can Learn from Fossilized Feces (http://nutritionfacts.org/video/paleopoo-what-we-can-learn-from-fossilized-feces/) • Egg Industry Response to Choline & TMAO (http://nutritionfacts.org/video/egg-industry-response-to-choline-and-tmao/) • Is Obesity Infectious? (http://nutritionfacts.org/video/is-obesity-infectious/) • How to Develop a Healthy Gut Ecosystem (http://nutritionfacts.org/video/How-to-Develop-a-Healthy-Gut-Ecosystem) More on health sources of prebiotics in: • Prebiotics: Tending our Inner Garden (http://nutritionfacts.org/video/prebiotics-tending-our-inner-garden/) • Gut Dysbiosis: Starving Our Microbial Self ---(mentioned in video?) (http://nutritionfacts.org/video/gut-dysbiosis-starving-microbial-self/) • Resistant Starch and Colon Cancer (http://nutritionfacts.org/videos/resistant-starch-and-colon-cancer) • Gut Microbiome - Strike It Rich with Whole Grains (http://nutritionfacts.org/videos/gut-microbiome-strike-it-rich-with-whole-grains) Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/how-to-become-a-fecal-transplant-super-donor and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/how-to-become-a-fecal-transplant-super-donor. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image credit: Newtown graffiti via flickr. Image has been modified. Icons created The Noun Project. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

What we eat determines what kind of bacteria we foster the growth of in our gut, which can increase or decrease our risk of some of our leading killer diseases. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ If that was the supplement industry’s response, how did the egg industry react? See my video Egg Industry Response to Choline and TMAO (http://nutritionfacts.org/video/egg-industry-response-to-choline-and-tmao). For more background on TMAO, see Carnitine, Choline, Cancer, and Cholesterol: The TMAO Connection (http://nutritionfacts.org/video/carnitine-choline-cancer-and-cholesterol-the-tmao-connection/). Our gut flora are what we eat! Check out: • Microbiome: The Inside Story (http://nutritionfacts.org/video/microbiome-the-inside-story) • Prebiotics: Tending Our Inner Garden (http://nutritionfacts.org/video/prebiotics-tending-our-inner-garden) • What’s Your Gut Microbiome Enterotype? (http://nutritionfacts.org/video/whats-your-gut-microbiome-enterotype) • How to Change Your Enterotype (http://nutritionfacts.org/video/how-to-change-your-enterotype) • Paleopoo: What We Can Learn from Fossilized Feces (http://nutritionfacts.org/video/paleopoo-what-we-can-learn-from-fossilized-feces/) • Gut Dysbiosis - Starving Our Microbial Self (http://nutritionfacts.org/video/gut-dysbiosis-starving-microbial-self) • Is Obesity Infectious? (http://nutritionfacts.org/video/is-obesity-infectious) Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/how-to-develop-a-healthy-gut-ecosystem and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/how-to-develop-a-healthy-gut-ecosystem. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image credit: MelSi via pixabay. Image has been modified. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

By now you probably know how important your gut health is to your overall health. If not, you need to! Eighty percent of your immune system is in your microbiome, your body’s bacteria, which help your body with just about every process, including digesting your food, thinking clearly, and even maintaining a healthy weight. Your […]

Should we be concerned about high-choline plant foods such as broccoli producing the same toxic TMAO that results from eating high-choline animal foods such as eggs? Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ Support NutritionFacts.org with a donation at http://www.NutritionFacts.org/donate. That was a fun video to record. Can you hear the frustration in my voice reading paper after paper proposing these ridiculous (but profitable!) answers when the safe, simple, side-effect free solution was staring them in the face the whole time? Makes me think of so many parallels, to the least of which are: • How Not to Die from Heart Disease (https://nutritionfacts.org/video/how-not-to-die-from-heart-disease/) • How Not to Die from Diabetes (https://nutritionfacts.org/video/how-not-to-die-from-diabetes/) • How Not to Die from High Blood Pressure (https://nutritionfacts.org/video/how-not-to-die-from-high-blood-pressure/) For more on TMAO, the “smoking gun” of diet-microbiome-disease interactions, see: • Eggs, Choline, and Cancer (httpss://nutritionfacts.org/video/eggs-choline-and-cancer/) • Carnitine, Choline, Cancer, and Cholesterol: The TMAO Connection (https://nutritionfacts.org/video/carnitine-choline-cancer-and-cholesterol-the-tmao-connection/) • Egg Industry Response to Choline and TMAO (https://nutritionfacts.org/video/egg-industry-response-to-choline-and-tmao) • How to Develop a Healthy Gut Ecosystem (httpss://nutritionfacts.org/video/how-to-develop-a-healthy-gut-ecosystem/) • How to Treat Heart Failure and Kidney Failure with Diet (https://nutritionfacts.org/video/How-to-Treat-Heart-Failure-and-Kidney-Failure-with-Diet) Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/how-to-reduce-your-tmao-levels and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/how-to-reduce-your-tmao-levels. You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image credit: Sally Plank via Flickr https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Antibiotics can be a controversial topic. While they can help tremendously for some specific infections in the body, they can also wreak your gut.

Given the role our gut bacteria can play in affecting our weight, having family and friends who are obese may not just be socially contagious but actually contagious. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ The earlier video I mentioned was Are Cats or Dogs More Protective for Children’s Health? (http://nutritionfacts.org/video/are-cats-or-dogs-more-protective-for-childrens-health). Viruses may also play a role in obesity. See Infectobesity: Adenovirus 36 and Childhood Obesity (http://nutritionfacts.org/video/infectobesity-adenovirus-36-and-childhood-obesity/). An Obesity Causing Chicken Virus (http://nutritionfacts.org/video/obesity-causing-chicken-virus) may help explain the link found between poultry consumption and weight gain (see Chicken Big: Poultry and Obesity (http://nutritionfacts.org/video/chicken-big-poultry-and-obesity)). The important question is Can Morbid Obesity Be Reversed Through Diet? (http://nutritionfacts.org/video/can-morbid-obesity-be-reversed-through-diet). That’s why I made the video! More on the amazing inner world in our guts, see: • Microbiome: The Inside Story (http://nutritionfacts.org/video/microbiome-the-inside-story) • Prebiotics: Tending Our Inner Garden (http://nutritionfacts.org/video/prebiotics-tending-our-inner-garden) • What’s Your Gut Microbiome Enterotype? (http://nutritionfacts.org/video/whats-your-gut-microbiome-enterotype) • How to Change Your Enterotype (http://nutritionfacts.org/video/how-to-change-your-enterotype) • Paleopoo: What We Can Learn from Fossilized Feces (http://nutritionfacts.org/video/paleopoo-what-we-can-learn-from-fossilized-feces) • Gut Dysbiosis - Starving Our Microbial Self (http://nutritionfacts.org/video/gut-dysbiosis-starving-microbial-self) Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/is-obesity-infectious and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/is-obesity-infectious. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image credit: Jay Malone via flickr. Image has been modified. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Much of the probiotic market was built on assumptions and hypotheses of how the gut functions. With the $157 million NIH Human Microbiome Project dramatically changing our understanding of the gut in the last 5 years, we have come to discover that the assumptions and hypotheses under which the vast majority of probiotic products are formulated are simply false. We have a paradigm shift in our understanding of probiotic therapy. This talk will discuss details of the new understanding of the human microbiome and how it specifically relates to health , including spectrum disorders. We ARE 10x more bacteria than we are human; bacteria that live in and on us play a significant role in how our body responds to stress, food, and our environment. Our microbes control many of our behaviors and can even influence what we eat. Recent research suggests an association between gut dysbiosis and onset of autism spectrum disorder. Physician-supervised protocols using probiotic strains that alleviate dysbiosis have resulted in corresponding reports of clinical improvement of symptoms in children.

Everything you eat or drink affects your intestinal bacteria, and is likely to have an impact on your health. That is the finding of a large-scale study into the effect of food and medicine on the bacterial diversity in the human gut.

There is currently a lack of long-term longitudinal studies investigating the stability of the microbiome. In this n-of-one study, we characterised th…

Background Late onset sepsis (LOS) in preterm infants is associated with considerable morbidity and mortality. While studies have implicated gut bacteria in the aetiology of the disease, functional analysis and mechanistic insights are generally lacking. We performed temporal bacterial (n = 613) and metabolomic (n = 63) profiling on extensively sampled stool from 7 infants with LOS and 28 matched healthy (no LOS or NEC) controls. Results The bacteria isolated in diagnostic blood culture usually corresponded to the dominant bacterial genera in the gut microbiome. Longitudinal changes were monitored based on preterm gut community types (PGCTs), where control infants had an increased number of PGCTs compared to LOS infants (P = 0.011). PGCT 6, characterised by Bifidobacteria dominance, was only present in control infants. Metabolite profiles differed between LOS and control infants at diagnosis and 7 days later, but not 7 days prior to diagnosis. Bifidobacteria was positively correlated with control metabolites, including raffinose, sucrose, and acetic acid. Conclusions Using multi-omic analysis, we show that the gut microbiome is involved in the pathogenesis of LOS. While the causative agent of LOS varies, it is usually abundant in the gut. Bifidobacteria dominance was associated with control infants, and the presence of this organism may directly protect, or act as a marker for protection, against gut epithelial translocation. While the metabolomic data is preliminary, the findings support that gut development and protection in preterm infants is associated with increased in prebiotic oligosaccharides (e.g. raffinose) and the growth of beneficial bacteria (e.g. Bifidobacterium).

A study raises concerns that the lower-fiber diets typical in industrialized societies may produce internal deficiencies that get passed along to future generations.

Register to watch next the Functional Forum: http://functionalforum.com/next-event Evolution of Medicine Presents: Sayer Ji Subscribe: https://bit.ly/2n9QpsC Join the EvoMed Practitioner FB Group: https://bit.ly/2KpOfON Health Advocates - Register to receive our newsletter: https://bit.ly/2vfggnj Sayer Ji, Founder of GreenMedInfo.com presents "Macro Implications of the Microbiome" on the February 2016 Functional Forum. http://goevomed.com/CL 5 STEPS TO BECOME A LEADER IN YOUR LOCAL HEALTH COMMUNITY ---------------------------------------------------------------------------------- Our team created a special free video just for you. It’s called "The 5 Steps To Become A Leader In Your Local Health Community" and reveals how to grow your influence, impact more people, while building a stronger practice and increase referrals. All you have to do is click here: http://goevomed.com/CL https://youtu.be/EfVuIm_OC4c Contact us: [email protected]

Gut microbes are well known to contribute to health and disease, but what has been less clear is how the host controls gut microbes. A study now reveals that mice and humans produce small molecules (microRNAs) from their GI tract, which are shed in feces, to regulate the composition of gut microbes and thereby protect against intestinal diseases such as colitis.