Alzheimers Parkinsons ALS

The spice saffron is pitted head-to-head against the leading drug for severe Alzheimer’s disease. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ Support NutritionFacts.org with a donation at http://www.NutritionFacts.org/donate. For more on herbal approaches to dementia, check out Best Aromatherapy Herb for Alzheimer's (https://nutritionfacts.org/video/best-aromatherapy-herb-for-alzheimers) and Treating Alzheimer's with Turmeric (https://nutritionfacts.org/video/treating-alzheimers-with-turmeric). What else can saffron do? See: • Saffron vs. Prozac (https://nutritionfacts.org/video/saffron-vs-prozac/) • Saffron for the Treatment of PMS (https://nutritionfacts.org/video/saffron-for-the-treatment-of-pms/) • Saffron for Erectile Dysfunction (http://www.nutritionfacts.org/topics/saffron-for-erectile-dysfunction) Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/saffron-vs-memantine-namenda-for-alzheimers and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/saffron-vs-memantine-namenda-for-alzheimers. You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Captions for this video are available in several languages. To find yours, click on the settings wheel on the lower-right of the video and then "Subtitles/CC." Do you have feedback about the translations in this video? Please share it here along with the title of the video and language: https://nutritionfacts.zendesk.com/hc/requests/new To view the subtitles in transcript format, click on the ellipsis button below the video, choose "Open transcript", and select the language you'd like to view them in. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Transgenic mice with increased amyloid-β (Aβ) production show several aspects of Alzheimer’s disease, including Aβ deposition and memory impairment. By repeatedly treating these Aβ-forming mice with scanning ultrasound, Leinenga and Götz now demonstrate that Aβ is removed and memory is restored as revealed by improvement in three memory tasks. These improvements were achieved without the use of any therapeutic agent, and the scanning ultrasound treatment did not induce any apparent damage to the mouse brain. The authors then showed that scanning ultrasound activated resident microglial cells that took up Aβ into their lysosomes. These findings suggest that repeated scanning ultrasound may be a noninvasive method with potential for treating Alzheimer’s disease. Amyloid-β (Aβ) peptide has been implicated in the pathogenesis of Alzheimer’s disease (AD). We present a nonpharmacological approach for removing Aβ and restoring memory function in a mouse model of AD in which Aβ is deposited in the brain. We used repeated scanning ultrasound (SUS) treatments of the mouse brain to remove Aβ, without the need for any additional therapeutic agent such as anti-Aβ antibody. Spinning disk confocal microscopy and high-resolution three-dimensional reconstruction revealed extensive internalization of Aβ into the lysosomes of activated microglia in mouse brains subjected to SUS, with no concomitant increase observed in the number of microglia. Plaque burden was reduced in SUS-treated AD mice compared to sham-treated animals, and cleared plaques were observed in 75% of SUS-treated mice. Treated AD mice also displayed improved performance on three memory tasks: the Y-maze, the novel object recognition test, and the active place avoidance task. Our findings suggest that repeated SUS is useful for removing Aβ in the mouse brain without causing overt damage, and should be explored further as a noninvasive method with therapeutic potential in AD.

Dr. Dale Bredesen has shown, using lifestyle changes like a ketogenic diet, that Alzheimer's Disease and dementia can be prevented and reversed.

Scientists have succeeded in sorting out the mechanism of Alzheimer's disease development and possibly distinguished its key trigger.

Although the potential contribution of the human gastrointestinal (GI) tract microbiome to human health, aging, and disease is becoming increasingly acknowledged, the molecular mechanics and signaling pathways of just how this is accomplished is not well-understood. Major bacterial species of the GI tract, such as the abundant Gram-negative bacilli Bacteroides fragilis (B. fragilis) and Escherichia coli (E. coli), secrete a remarkably complex array of pro-inflammatory neurotoxins which, when released from the confines of the healthy GI tract, are pathogenic and highly detrimental to the homeostatic function of neurons in the central nervous system (CNS). For the first time here we report the presence of bacterial lipopolysaccharide (LPS) in brain lysates from the hippocampus and superior temporal lobe neocortex of Alzheimer's disease (AD) brains. Mean LPS levels varied from two-fold increases in the neocortex to three-fold increases in the hippocampus, AD over age-matched controls, however some samples from advanced AD hippocampal cases exhibited up to a 26-fold increase in LPS over age-matched controls. This “Perspectives” paper will further highlight some very recent research on GI tract microbiome signaling to the human CNS, and will update current findings that implicate GI tract microbiome-derived LPS as an important internal contributor to inflammatory degeneration in the CNS.

A new theory for the causes of dementia and other neurodegenerative diseases has been developed, involving an out-of-control immune system.

This is incredible.

Diet may explain the Nigerian Paradox, where they have among the highest rates of the Alzheimer’s susceptibility gene, ApoE4, but among the lowest rates of Alzheimer’s disease. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ What dietary changes? See some of my latest videos on preventing Alzheimer’s disease: • Preventing Alzheimer’s with Lifestyle Changes (http://nutritionfacts.org/video/preventing-alzheimers-with-lifestyle-changes) • Preventing Alzheimer’s Disease with Diet (http://nutritionfacts.org/video/preventing-alzheimers-disease-with-diet) • Preventing Alzheimer’s Disease With Plants (http://nutritionfacts.org/video/Preventing-Alzheimers-Disease-With-Plants/) • Reducing Glycotoxin Intake to Prevent Alzheimers (http://nutritionfacts.org/video/Reducing-Glycotoxin-Intake-to-Prevent-Alzheimers) • Alzheimer’s May Start Decades Before Diagnosis (http://nutritionfacts.org/video/alzheimers-may-start-decades-before-diagnosis) • Alzheimer’s and Atherosclerosis of the Brain (http://nutritionfacts.org/video/alzheimers-and-atherosclerosis-of-the-brain) • Cholesterol and Alzheimer’s disease (http://nutritionfacts.org/video/cholesterol-and-alzheimers-disease) This concept of switching genes on and off is the exciting world of epigenetics. For more, see BRCA Breast Cancer Genes (http://nutritionfacts.org/video/brca-breast-cancer-genes-and-soy/) and Soy and Cancer Reversal Through Diet? (http://nutritionfacts.org/video/cancer-reversal-through-diet/). Have a question for Dr. Greger about this video? Leave it in the comment section at http://nutritionfacts.org/video/the-alzheimers-gene-controlling-apoe and he'll try to answer it! Image Credit: PublicDomainPictures via Pixabay. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Alzheimer's disease (AD) is a leading killer of Americans, imparts a significant toll on the quality of life of the patient and primary caregiver, and results in inordinate costs in an already overburdened medical system. Prior studies on cholinesterase inhibitors among AD patients have shown minima …

Dr. David Perlmutter, author of Grain Brain, interview Dr. Dale Bredesen, the author of The End of Alzheimer's and a medical pioneer.

The End of Alzheimer's Program: The First Protocol to Enhance Cognition and Reverse Decline at Any Age [Bredesen, Dale, Perlmutter, David] on Amazon.com. *FREE* shipping on qualifying offers. The End of Alzheimer's Program: The First Protocol to Enhance Cognition and Reverse Decline at Any Age

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Today’s short video clip with Dr. Daniel Stein, dives deep into how to TREAT this horrific disease. You’ll discover the exact cannabinoids, terpenes and dosage protocol Dr. Stein recommends... *** This limited clip is a preview from our Healing Brain Masterclass. Get full access to our entire 3 masterclass library, complete season 1 docuseries, and over 37 bonuses on a portable 100+ GB flash drive... Go here for all the details 👉 http://bit.ly/2rl3F33

Researchers in Sweden have discovered a new function for vitamin C. Treatment with vitamin C can dissolve the toxic protein aggregates that build up in the brain in Alzheimer's disease.

Abnormal accumulation of amyloid proteins is linked to neuronal degeneration in Alzheimer's disease brains, driving cognitive decline. Disruption of autophagy pathway contributes to the development o...

The disaccharide trehalose is commonly considered to stimulate autophagy. Cell treatment with trehalose could decrease cytosolic aggregates of potentially pathogenic proteins, including mutant huntingtin, α-synuclein, and phosphorylated tau that are associated with neurodegenerative diseases. Here, …

This study assessed the therapeutic utility of the autophagy enhancing stable disaccharide trehalose in the Tg2576 transgenic mouse model of Alzheimer's disease (AD) via an oral gavage of a 2% trehalose solution for 31 days. Furthermore, as AD is a neurodegenerative condition in which the transition …

Alzheimer's disease is an irreversible and progressive brain disorder featured by the accumulation of Amyloid-β (Aβ) peptide, which forms insoluble assemblies that builds up into plaques resulting in cognitive decline and memory loss. The formation of fibrillar amyloid deposits is accompanied by con …

Turmeric has been used in India for over 5,000 years, which is likely why still today both rural and urban populations have some of the lowest prevalence rates of Alzheimer's disease (AD) in the world. A study on patients with AD found that less than a gram of turmeric daily, taken for three months, resulted in 'remarkable improvements'

Researchers at UCLA say they've developed a program that shows for the first time Alzheimer's memory loss being reversed in some patients.

An aging specialist discusses 10 main signs of Alzheimer's disease and the importance of obtaining an early diagnosis. More than 5 million people in the United States have Alzheimer's disease, according to the Alzheimer's Association. Not only is Alzheimer's disease the sixth leading cause of death in the country, but it also currently cannot be prevented, cured or slowed.

A new study is helping to explain why the long-term use of common anticholinergic drugs used to treat conditions like allergies and overactive bladder lead to an increased risk of developing dementia later in life. The study used mouse models to show that long-term suppression of the neurotransmitter acetylcholine -- a target for anticholinergic drugs -- results in dementia-like changes in the brain.

Inhibition of platelets in Alzheimer's disease patients may become important in therapy in future, say researchers whose findings could be of great importance for the treatment of Alzheimer's disease patients.

A new study in the journal Neurology explores the scientific fact behind the relationship between vitamin D and dementia and Alzheimer's