Aloe

Background: Rheumatoid arthritis is a chronic inflammatory disease of autoimmune etiology. Current treatment includes non-steroidal anti-inflammatory drugs, selective cyclooxygenase-2 inhibitors, glucocorticoids, and disease-modifying antirheumatoid drugs, newer agents such as tumor necrosis factor-α inhibitors, and monoclonal antibodies have adverse effects such as peptic ulcer, renal toxicity, and hematological toxicity. Moreover, they are expensive when used on a long-term basis. Hence, it is necessary to find out the new cost effective as well as less toxic drug as alternative. Aim and Objective: The present study was taken up to evaluate antiarthritic activity of Aloe vera aqueous extract (AVE) in Wistar albino rats when used orally. Materials and Methods: A total 36 no. of healthy Wistar albino rats of weight 100–200 mg were used and divided into six different groups containing six rats in each. Into subplantar region of hind paw of all rats except normal control, 0.1 mL of complete Freund’s adjuvant (6 mg Mycobacterium butyricum suspended in heavy paraffin oil) was injected for induction of arthritis. The rats were treated with vehicle (gum acacia), standard drugs (indomethacin and dexamethasone) and test drug, that is, AVE 125 mg/kg, 250 mg/kg for 12 days. The rats were evaluated by measuring the % increase in paw edema volume and paw thickness (joint diameter), assessing the biophysical parameters (arthritic score), hematological parameters erythrocyte sedimentation rate, rheumatoid factor, and histopathological study of joints (arthritic index) for testing the antiarthritic potential. Results: AVE 250 mg/kg showed significant antiarthritic property as that of standard indomethacin and dexamethasone in terms of reduction in inflammation and arthritic scores. Conclusion: AVE at 250 mg/kg offered significant protection against arthritis and inflammation and can be a safer alternative for long term use.

Background. Aloe vera has long been considered an anticancer herb in different parts of the world. Objective. To explore the potential mechanism of aloe vera in the treatment of cancer using network pharmacology and molecule docking approaches. Methods. The active ingredients and corresponding protein targets of aloe vera were identified from the TCMSP database. Targets related to cancer were obtained from GeneCards and OMIM databases. The anticancer targets of aloe vera were obtained by intersecting the drug targets with the disease targets, and the process was presented in the form of a Venn plot. These targets were uploaded to the String database for protein-protein interaction (PPI) analysis, and the result was visualized by Cytoscape software. Go and KEGG enrichment were used to analyze the biological process of the target proteins. Molecular docking was used to verify the relationship between the active ingredients of aloe vera and predicted targets. Results. By screening and analyzing, 8 active ingredients and 174 anticancer targets of aloe vera were obtained. The active ingredient-anticancer target network constructed by Cytoscape software indicated that quercetin, arachidonic acid, aloe-emodin, and beta-carotene, which have more than 4 gene targets, may play crucial roles. In the PPI network, AKT1, TP53, and VEGFA have the top 3 highest values. The anticancer targets of aloe vera were mainly involved in pathways in cancer, prostate cancer, bladder cancer, pancreatic cancer, and non-small-cell lung cancer and the TNF signaling pathway. The results of molecular docking suggested that the binding ability between TP53 and quercetin was the strongest. Conclusion. This study revealed the active ingredients of aloe vera and the potential mechanism underlying its anticancer effect based on network pharmacology and provided ideas for further research.

Aloe vera extract and its bioactive compounds possess anti-proliferative properties against cancer cells. However, no detailed molecular mechanism of …

Mukesh Kumar Sharma1,2*, Jagat Chauhan1, Mohan Kumar1, Chetan Kumar Joshi3, Sandeep Sharma4 and Chhagan Lal5 Article: 7205 Full Text

One of the simplest and safest ways to treat diabetes is exercise regularly and Consumption of herbal medicines that have few side effects. The aim of this study was to evaluate the effect of high-intensity interval training with aloe vera supplementation on some selected adipokines in type 2 diabetic men. In this quasi-experimental study, 44 men with type 2 diabetes (mean age 25-40 years) were randomly divided into four groups (n=11) of control, aloe vera, exercise and exercise- aloe vera groups. High-intensity interval training were performed 3 sessions per week for 12 weeks. Subjects received an aloe vera capsule containing 100 mg of aloe vera gel powder in the morning immediately after waking up and one capsule after dinner. Blood samples and anthropometric characteristics were obtained before and after the intervention. Data were analyzed using two-way ANOVA with repeated measures, t-test and Tukey post hoc test at P

ABSTRACTBackground: Acrylamide, an industrial chemical found in many industrial applications as well as for chemical and environmental purposes. The Aloe vera plant Known for many years and was known and used for its health, beauty, medicinal and skin care properties. The name Aloe vera derives from the Arabic word “Alloeh” meaning “shining bitter substance,” while “vera” in Latin means “true.” 2000 years ago.Objective: The aim of the study was to evaluate the role of the Aloe vera extract and its influence on experimental lesions in the jujenal mucosa caused by Acrylamide.Materials and Method: Thirty adult female albino rats were used and divided equally into three groups (10 rat/eachgroup): (I)control group. (II)Acrylamide treated group (5 mg/kg/day). (III) Acrylamide&Aloe vera treatedgroup (0.4 ml/100g).The experiment extended for 3 weeks, thejejunum samples were collected, prepared and studded by light microscope and scanning electron microscope.Results: This study revealed that acrylamide administration to rats induces pathological changes in the jejunum in the form of the fused villi;irregular mucosal folds; cellular infiltration and thickened discontinued muscularis externa, with electron microscopic study there were areas of erosion and ulceration of the villi with loss of the normal picture . Administration of Aloe vera gel restored the normal architecture of the villi and crypts with normal appearance of most layers, scanning electron microscopy showed intact epithelium withgoblet cells openings discharging mucus.Conclusion:Acrylamide markedly affect the jujenal mucosa as seen by light and electron microscope, Aloe vera gel administration can protect the mucosa from this harmful effect.Keywords: Acrylamide, Aloe vera, jejunum, Rats.

Introduction: Anti-inflammatory compounds are effective in improving the symptoms of inflammatory bowel diseases such as ulcerative colitis. The aim of this study was to evaluate the effect of aloe vera extract on the inflammatory factors affecting acetic acid-induced ulcerative colitis. Materials and Methods: 32 male Wistar rats are divided in ...

Decontamination of air, soil, and water polluted with dangerous mercury, cadmium, arsenic, and chromium by plants is called phytoremediation. As a living plant, Aloe vera was used to clean up the soil, water and air contaminated with dangerous heavy metals and gas. Aloe vera plant and the waste powder occurred from aloe vera gel processing, were applied for phytoremediation in which Aloe vera was proposed as a cost-effective plant-based approach of environmental remediation. Bioleaching is a process of extracting metals from their ores through the use of living microorganisms. Endophytic bacteria in Aloe vera gel could be used as bioleaching of heavy metals. Furthermore the detoxification of heavy metals and hepato-therapeutic effects by Aloe vera was focused specially on hepatic fibrosis and chronic kidney diseases. Case reports showed the suppression of gall bladder hypertrophy and ureteral stone by aloe vera supplements.

Aloe barbadensis Miller, commonly known as Aloe vera has been used since time immemorial for treatment of various diseases such as cancer, inflammator…

Aloe vera is a functional food with various pharmacological functions, including an immune-modulating effect. Until now, A. vera has never been studie…

Cardiovascular diseases (CVDs) comprise the most prevalent causes of morbidity and mortality in both men and women worldwide. CVDs are associated with several risk factors such as hyperlipidemia, dia...

Aloe vera (L.) Burm. f. is a typical traditional Chinese medicine (TCM) collected in the Pharmacopoeia of the People's Republic of China (version 2015…

This study aimed to investigate the interactive effect of aloe vera intake and eight weeks’ aerobic exercise on serum BDNF, glucose, and insulin levels in women with type 2 diabetes. In this experimental study, 32 women with type 2 diabetes were selected and randomly divided into four groups of control, supplement, exercise, exercise + supplement. The exercise program was performed 3 sessions per week for 8 weeks (40 min of exercise with 50-60% of heart rate reserve in the first four weeks and 60 min of exercise with 60-80% of heart rate reserve in the second four weeks). The supplement taking groups received 400 mg/kg of oral aloe Vera 3 days per week for 8 weeks. The data were analyzed using analysis of covariance (ANCOVA). A significant increase was observed in BDNF levels, insulin sensitivity of patients in the supplement, exercise, and exercise + supplement groups (p=0.001). The glucose and insulin levels, insulin resistance, BMI, and body fat percentage significantly decreased in the supplement, exercise, and exercise + supplement groups (p=0.001). It seems aloe Vera intake and aerobic exercise to have protective effects against development of type 2 diabetes complications in women.

ScholarWorks@Gachon: The Role of Processed Aloe vera Gel in Intestinal Tight Junction: An In Vivo and In Vitro Study

Annals of Oncology, the journal of the European Society for Medical Oncology and the Japanese Society of Medical Oncology, provides rapid and efficient peer-review publications on innovative cancer...

Around 1750 BC Hannibal waged war to control the areas in North Africa where aloe vera flourished. It's no wonder when you understand the powerful medicine contained in this plant

Recurrent aphthous stomatitis (RAS) is the most common disorder in the oral mucosa that affects the daily quality of life of patients, and there is currently no specific treatment. In the present study, we developed aloe vera fermentation gel under the action of probiotics on aloe vera. In total, 35 patients with the history of aphthous stomatitis were enrolled to explore the potential benefits of aloe vera fermentation gel to treat RAS, and the healing-promotion effects were recorded and compared; microbial compositions in different groups were tested by high-throughput sequencing. Our results indicated that the duration of healing time of the aloe group showed potentially better effects because of the higher proportion of 4–6 day healing time (35% vs. 20%) and lower proportion of 7–10 day healing time (65% vs. 80%) compared with that of the chitosan group. Also, the use of aloe vera fermentation gel could return oral bacteria to normal levels and reduce the abundance of harmful oral bacteria including Actinomyces, Granulicatella, and Peptostreptococcus. These results suggest that aloe vera fermentation gel has the ability to treat patients with RAS and has positive prospects in clinical applications.

Clinicians and wound care nurses in Indonesia usually use Nigella sativa oil (NSO) gel and aloe vera (AV) gel to treat diabetic ulcers. However, there are no st...

Clinicians and wound care nurses in Indonesia usually use Nigella sativa oil (NSO) gel and aloe vera (AV) gel to treat diabetic ulcers. However, there are no st...

Objective Corrosion Reviews is an international bimonthly journal devoted to critical reviews and, to a lesser extent, outstanding original articles that are key to advancing the understanding and application of corrosion science and engineering in the service of society. Papers may be of a theoretical, experimental or practical nature, provided that they make a significant contribution to knowledge in the field. Topics Cutting-edge topics such as but not limited to the following: Corrosion of materials in energy systems Corrosion of biomaterials and medical devices Corrosion of materials in the chemical process industries High temperature corrosion Nuclear waste disposal The effect of corrosion on water pollution and the environment Corrosion of advanced materials Degradation of non-metals Corrosion control and monitoring techniques Modeling and life prediction Article formats Review articles and high-relevant original articles > Information on submission process

Reactive oxygen species (ROS) are implicated in the aetiology of gastric disorders and are a key pathogenic feature in gastric mucosal injury. Interve…

Several factors limit the absorption and bioavailability of vitamins. Vitamin C, a commonly used water-soluble supplement reduces the risk of disease. Vitamin B(12) is necessary for the development of RBC, growth, and nervous system. Vitamin B(12) deficiency is common among elderly. Thus, agents tha …

This study seems to suggest that Aloe may be successfully associated with chemotherapy to increase its efficacy in terms of both tumor regression rate and survival time.