Aloe

Background Aloe vera is a perennial, succulent, drought-resistant plant that exhibits many pharmacological characteristics such as wound healing ability against skin burns, anti-ulcer, anti-inflammatory, anti-tumor, anti-viral, anti-hypercholesterolemic, anti-hyperglycemic, anti-asthmatic and much more. Despite great medicinal worth, little genomic information is available on Aloe vera. This study is an initiative to explore the full-scale functional genomics of Aloe vera by generating whole transcriptome sequence database, using Illumina HiSeq technology and its progressive annotation specifically with respect to the metabolic specificity of the plant. Results Transcriptome sequencing of root and leaf tissue of Aloe vera was performed using Illumina paired-end sequencing technology. De novo assembly of high quality paired-end reads, resulted into 1,61,733 and 2,21,792 transcripts with mean length of 709 and 714 nucleotides for root and leaf respectively. The non-redundant transcripts were clustered using CD-HIT-EST, yielding a total of 1,13,063 and 1,41,310 unigenes for root and leaf respectively. A total of 6114 and 6527 CDS for root and leaf tissue were enriched into 24 different biological pathway categories using KEGG pathway database. DGE profile prepared by calculating FPKM values was analyzed for differential expression of specific gene encoding enzymes involved in secondary metabolite biosynthesis. Sixteen putative genes related to saponin, lignin, anthraquinone, and carotenoid biosynthesis were selected for quantitative expression by real-time PCR. DGE as well as qRT PCR expression analysis represented up-regulation of secondary metabolic genes in root as compared to leaf. Furthermore maximum number of genes was found to be up-regulated after the induction of methyl jasmonate, which stipulates the association of secondary metabolite synthesis with the plant’s defense mechanism during stress. Various transcription factors including bHLH, NAC, MYB were identified by searching predicted CDS against PlantTFdb. Conclusions This is the first transcriptome database of Aloe vera and can be potentially utilized to characterize the genes involved in the biosynthesis of important secondary metabolites, metabolic regulation, signal transduction mechanism, understanding function of a particular gene in the biology and physiology of plant of this species as well as other species of Aloe genus.

Abstract Aloe vera possesses a great therapeutic importance in traditional medicine. It has...

Aloe Vera is a medicinal plant as antioxidants reduce cell damage and used. The purpose of this study was to determine the effect of Aloe Vera on lactate de-hydrogenase after a period of aerobic exercise in male athletes. Methods This study applied the method according to the nature of the study, based on semi-empirical research and a review of the pre-test, post-test supplements and placebo groups, respectively. In this study,20 male students weight was 64.85 ± .51 and height was 172.05 ± 6.4 were randomly assigned to two groups of Imam Ali College of Physical Education Supplement (n = 10) and placebo (10 people). Then aerobic training was conducted for 4 weeks in the supplemented group were taking 3 capsules, each capsule contains 2 grams of dried Aloe Vera and placebo group were taking 3 capsules containing Dextrin daily after every meal. To determine the index of LDH were used and blood samples were collected 24 hours before and after each test Cooper with student in the lab. To describe data, analytical data, and for the mean and standard deviation of repeated measures ANOVA and independent T-test was used for comparison between groups Significance level was P ≤ 0.05. The use of Aloe Vera during aerobic exercise significantly, cautious reduced LDH (P=0.006) in the supplement group compared to placebo was 15% reduction. Conclusion: Overall the findings of this study showed that Aloe Vera reduces lactate de-hydrogenase. This result may reflect the role of Aloe Vera has anti-inflammatory and antioxidant.

Dyslipidemia is a common feature of type 2 diabetes mellitus and is characterised by elevated triglyceride, decreased HDL cholesterol, and increased s…

Aloe vera is a medical plant that has been used, traditionally, in treatment of several dermal disorders. In addition to its role as an anti-cancer, a…

Fat-rich diets are believed to induce obesity and contribute to the development of diabetes and cardiovascular disease in contrast high fructose diet …

Chitosan-based hydrogels as wound dressings are expected to improve the efficiency of the wound-healing process. Fabrication of the composite structur…

The non-digestible polysaccharide acemannan in Aloe vera gel is highly butyrate fermentable dietary fiber. The relationship between Alzheimer’s disease and related dementia with butyrogenic microbiota and butyrate fermented was discussed in the prevention of human physiological disease such as Alzheimer’s disease and dementia progression. In case report 1, it was suggested that the efficacy of hypotensive, hypoglycemic, antianginal, and cognition enhancer drug for a frail female patient needed the nursing care level 2, may be supported with daily ingestion of aloe vera juice with the drug and multivitamin modulating from the nursing care level 2 into 1 and providing an important role in the modulation of brain homeostasis.

The anti-cancer effects of Aloe vera barbadensis extract C (AVBEC) have been demonstrated in a previous study. However, the specific functional ingred…

Protective agent for hepatotoxicity is still a great challenge in the management of liver diseases. Aloe vera is a beneficial plant that has been studied for food supplements, cosmetic and herbal medicine. Aloe vera contains many compounds which have a role in body health including polysaccharides, phenolic, flavonoid, terpenoid, amino acid, and several minerals. There have been compelling evidences that natural phytochemicals and their derivatives have hepatoprotective activities. Information of the aloe vera and its mechanism of action for possible hepatoprotective activities, including in silico, in vitro, and in vivo studies were obtained from Pubmed, Science Direct, Scopus, and Google scholar search engines. This current review was focusing on the possible contribution of compounds inside aloe vera gel and the suggestion of its mechanism on protective effect, especially for liver. The complexity of monosaccharides composition, backbone structures, acetyl group, and molecular weight of aloe polysaccharides have possible correlations with its hepatoprotective effect. Most of the hepatoprotective mechanisms of aloe compounds are related to their protective effect against inflammation and oxidative stress. Several compounds may have combination effects or several targets lead to synergistic effects. Keywords: Aloe vera, food supplement, hepatoprotective, liver disease, mechanism of action.

Revista Brasileira de Farmacognosia - Diabetes mellitus is defined as prolonged hyperglycemia, which can harm the eyes, kidneys, and cardiovascular and neurological systems. Herbal agents and their...

Aloe vera products, both in food and cosmetics, are becoming increasingly popular due to their claimed beneficial effects, which are mainly attributed to the active compound acemannan. Usually, these end products are based on powdered starting materials. High temperatures during the drying process to obtain the starting materials have several advantages, like shortening the drying time, eliminating toxic aloin and reducing bacterial contamination. Nevertheless, there are two major drawbacks: first, at temperatures of 80 °C or higher, structural changes in acemannan, especially its deacetylation (>46%), are triggered, which does not happen at lower temperatures (14% at 60 °C); secondly, a toxic principle is formed at higher temperatures, resulting in a higher cytotoxicity. Thus, two temperature-dependent but opposing effects cause with a median cytotoxic concentration of CC50 = 0.4× a peak of cytotoxicity at 80 °C; at 60 °C this cytotoxic substance is not formed and at 100 °C aloin is more readily eliminated, resulting in a CC50 = 1.1× and CC50 = 1.4×, respectively. The cytotoxic substance generated by dry heat at 80 °C is not a modified polysaccharide because its polysaccharide-enriched alcohol-insoluble fraction is with CC50 = 0.9× less cytotoxic. Moreover, this substance is polar enough to be washed away with ethanol. Additionally, when Aloe gel is heated at 80 °C under humid conditions (pasteurization), the cytotoxicity does not increase (CC50 = 1.6×). Finally, to produce powdered starting materials from Aloe gel, it is recommended to use temperatures of around 60 °C in order to preserve the acemannan structure (and thus biological activity) and the low cytotoxicity.

The purpose of this study was to determine the effectiveness of aloe vera juice against stomach acid. Aloe vera also contains key elements such as resin, aloin, tannins, aloin-emodin, polysaccharides, 19 amino acids, 12 vitamins and 20 minerals that are important for health. Aloe vera is a natural ingredient that is good for detoxifying heavy metals in the body, and is able to maximize the performance of the digestive system. consuming aloe vera juice in a certain dose, is very effective for healing wounds in the stomach, as well as being a natural remedy for stomach ulcers which is quite effective. Aloe vera has the ability to stimulate the release of pepsin, which is an enzyme in the stomach that works to support the digestive system

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Objective: To compared efficacy of alpha lipoic acid (antioxidant medication) and aloe vera gel together versus intralesional steroids (hydrocortisone) in management of oral submucous fibrosis by evaluating post treatment clinical features of mouth opening and burning sensation. Study Design: A prospective comparative study. Place and Duration of Study: Department of ENT, Combined Military Hospital, Malir Karachi, from Jul 2018 to Mar 2020. Methodology: Twenty-eight patients were involved in the research and were distributed into two groups, I and II. Alpha lipoid acid with aloe vera gel was given in group I and hydrocortisone was given in group II. Burning sensation and mouth opening were recorded both at start and at monthly interval later on for three consecutive months. The data collected were statistically analyzed by using SPSS-22. Results: A significant lessening in burning sensation (p

Background: Rheumatoid arthritis is a chronic inflammatory disease of autoimmune etiology. Current treatment includes non-steroidal anti-inflammatory drugs, selective cyclooxygenase-2 inhibitors, glucocorticoids, and disease-modifying antirheumatoid drugs, newer agents such as tumor necrosis factor-α inhibitors, and monoclonal antibodies have adverse effects such as peptic ulcer, renal toxicity, and hematological toxicity. Moreover, they are expensive when used on a long-term basis. Hence, it is necessary to find out the new cost effective as well as less toxic drug as alternative. Aim and Objective: The present study was taken up to evaluate antiarthritic activity of Aloe vera aqueous extract (AVE) in Wistar albino rats when used orally. Materials and Methods: A total 36 no. of healthy Wistar albino rats of weight 100–200 mg were used and divided into six different groups containing six rats in each. Into subplantar region of hind paw of all rats except normal control, 0.1 mL of complete Freund’s adjuvant (6 mg Mycobacterium butyricum suspended in heavy paraffin oil) was injected for induction of arthritis. The rats were treated with vehicle (gum acacia), standard drugs (indomethacin and dexamethasone) and test drug, that is, AVE 125 mg/kg, 250 mg/kg for 12 days. The rats were evaluated by measuring the % increase in paw edema volume and paw thickness (joint diameter), assessing the biophysical parameters (arthritic score), hematological parameters erythrocyte sedimentation rate, rheumatoid factor, and histopathological study of joints (arthritic index) for testing the antiarthritic potential. Results: AVE 250 mg/kg showed significant antiarthritic property as that of standard indomethacin and dexamethasone in terms of reduction in inflammation and arthritic scores. Conclusion: AVE at 250 mg/kg offered significant protection against arthritis and inflammation and can be a safer alternative for long term use.