Background: Rare sugar D-Allulose, a zero-calorie sweetener, markedly ameliorates obesity.

Estrogen deficiency after menopause promotes visceral fat accumulation and insulin resistance, thereby increasing the risk of type 2 diabetes.

Obesity remains a significant public health concern, with recent studies revealing that the detrimental health effects often persist even in individuals who have successfully shed excess weight. D-allulose, a low-calorie monosaccharide, has shown potential in promoting weight loss and reducing chronic inflammation associated with metabolic disorders. However, it is still unclear whether D-allulose has long-term benefits once intake is stopped. This study examined the prolonged effects of D-allulose on obesity and metaflammation. Our findings demonstrated that obese mice treated with D-allulose for one month maintained significantly lower lipid accumulation, fasting blood glucose level, glycosylated protein levels, and reduced adipose tissue inflammation compared to the Model group, even 75 days after cessation of D-allulose intake. Further cellular analyses revealed that D-allulose attenuated the activation and expression of TLR4/MyD88/NFB pathway in macrophages triggered by inflammatory stimuli. Additionally, D-allulose administration was associated with reduced protein lactylation levels in macrophages, suggesting that D-allulose may exert lasting benefits through epigenetic regulation mechanisms. These results underscore the sustained efficacy of D-allulose in combating fat accumulation, blood glucose, and inflammation, presenting a promising therapeutic approach for mitigating the residual adverse effects of obesity in individuals who have achieved weight loss.

D-allulose is a rare monosaccharide with established safety and documented biological functions, whereas its potential effects on ulcerative colitis r…

The acute effect of D-allulose consumption on postprandial glycaemia and insulin secretion in healthy individuals - Volume 84 Issue OCE4

Excessive sugar intake has fueled global obesity, diabetes, and cardiovascular burdens, driving demand for natural sugar substitutes. Yet, their safet…

This study investigated the anti-obesity and anti-inflammatory effects of D-Allulose compared to erythritol in high-fat diet (HFD)-fed mice, focusing …

We have clearly entered a new era when mainstream science has come to embrace the notion that nutrition exerts significant influence over various physiological functions, including immune regulation, and may …

Fructose and Metabolic SyndromeCell Metabolism: https://pubmed.ncbi.nlm.nih.gov/32502381/ Fructose, intracellular pathwayJ. Biol Chem: https://pubmed.ncbi.nl...

Allulose is on the top of my sweetener preference list for both objective and subjective reasons.

Allulose, a rare sugar, has gained significant attention in recent years due to its numerous health benefits, primarily concerning metabolic health. To be sure, it seems like it is everywhere …

D-Allulose, a rare sugar and C3-epimer of D-fructose has been proposed as a candidate for dietary restriction mimetics via inhibition of glycolysis. Anti-hyperglycemic and anti-obesity effects have been reported in rodents and human subjects. Here, ...

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D-allulose, a rare sugar recognized as Generally Recognized as Safe, has emerged as a potential alternative to sucrose. Despite its growing popularity…

D-Allulose has blood glucose suppression effects in both animal and clinical studies. The mechanism mediating glucose suppression in animals is contro …

D-Allulose (D-psicose) is a rare sugar and a C-3 epimer of D-fructose. D-Allulose has been reported to have several health benefits via its alteration …

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Discover the benefits of allulose for Type 1 diabetes management and therapeutic carbohydrate reduction (TCR). Join us as we explore this promising sugar substitute!

Natural rare sugars are an alternative category of sweeteners with positive physiologic and metabolic effects both in in vitro and animal models. D-allulose is a D-fructose epimer that combines 70% sucrose sweetness with the advantage of an extremely low energy content. However, there are no data about the effect of D-allulose against adipose dysfunction; thus, it remains to be confirmed whether D-allulose is useful in the prevention and in treatment of adipose tissue alterations. With this aim, we evaluated D-allulose’s preventive effects on lipid accumulation in 3T3-L1 murine adipocytes exposed to palmitic acid (PA), a trigger for hypertrophic adipocytes. D-allulose in place of glucose prevented adipocyte hypertrophy and the activation of adipogenic markers C/EBP-β and PPARγ induced by high PA concentrations. Additionally, D-allulose pretreatment inhibited the NF-κB pathway and endoplasmic reticulum stress caused by PA, through activation of the Nrf2 pathway. Interestingly, these effects were also observed as D-allulose post PA treatment. Although our data need to be confirmed through in vivo models, our findings suggest that incorporating D-allulose as a glucose substitute in the diet might have a protective role in adipocyte function and support a unique mechanism of action in this sugar as a preventive or therapeutic compound against PA lipotoxicity through the modulation of pathways connected to lipid transport and metabolism.

Sugar consumption is known to be associated with a whole range of adverse health effects, including overweight status and type II diabetes mellitus. In 2015, the World Health Organization issued a guideline recommending the reduction of sugar intake. In this context, alternative sweeteners have gained interest as sugar substitutes to achieve this goal without loss of the sweet taste. This review aims to provide an overview of the scientific literature and establish a reference tool for selected conventional sweeteners (sucrose, glucose, and fructose) and alternative sweeteners (sucralose, xylitol, erythritol, and D-allulose), specifically focusing on their important metabolic effects. The results show that alternative sweeteners constitute a diverse group, and each substance exhibits one or more metabolic effects. Therefore, no sweetener can be considered to be inert. Additionally, xylitol, erythritol, and D-allulose seem promising as alternative sweeteners due to favorable metabolic outcomes. These alternative sweeteners replicate the benefits of sugars (e.g., sweetness and gastrointestinal hormone release) while circumventing the detrimental effects of these substances on human health.

Delicious, Plant-based Certified, Non-GMO Project Verified, Keto Certified Allulose Sugar  Zero Calories Zero Net Carbs Zero Sugar Alcohols Zero Stevia Zero Monk Fruit Zero Erythritol RxSugar®. There Is No Substitute.® Non-GMO Project Verified Grain-Free/Gluten-Free Certified Keto Certified FODMAP Friendly Certified Blood Sugar Friendly Safe for People With Diabetes  1.25 cups RxSugar® Allulose Sugar = 1 cup Refined Sugar *You may receive packaging that looks different while we transition designs.   ◄Ingredients Non-GMO Allulose RxSugar® is made from Allulose, a low calorie plant-based sugar, is different from other sugars in that it is not metabolized by the human body in the same way as table sugar. RxSugar® does not affect your blood sugar levels. Allulose, is proven to have zero net carbohydrate impact; this is why the Allulose carbohydrates are subtracted from the Total Carbs to produce zero net carbohydrates. How To Calculate Net

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Metabolic changes have been linked to the development of inflammatory bowel disease (IBD), which includes colitis. Allulose, an endogenous bioactive m…

D-Allulose is a rare sugar that exists in nature. It is a food ingredient with nearly zero calories (

#allulose #sweetener #sugarsubstitute Allulose is gaining in popularity but does the latest evidence support the described health benefits? More importantly ...

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