Background: Colonic microbiome is thought to be involved in auto-immune multiple sclerosis (MS). Interactions between diet and the colonic microbiome in MS are unknown.Methods: We compared the composition of the colonic microbiota quantitatively in 25 MS patients and 14 healthy controls.Fluorescence in situ hybridization (FISH) with 162 ribosomal RNA derived bacterial FISH probes was used. Ten of the MS patients received a ketogenic diet for 6 months. Changes in concentrations of 35 numerically substantial bacterial groups were monitored at baseline and at 2, 12, and 23/24 weeks.Results: No MS typical microbiome pattern was apparent.The total concentrations and diversity of substantial bacterial groups were reduced in MS patients (P Roseburia), Bac303 (Bacteroides), and Fprau (Faecalibacterium prausnitzii) probes were diminished the most. The individual changes were multidirectional and inconsistent. The effects of a ketogenic diet were biphasic. In the short term, bacterial concentrations and diversity were further reduced. They started to recover at week 12 and exceeded significantly the baseline values after 23–24 weeks on the ketogenic diet.Conclusions: Colonic biofermentative function is markedly impaired in MS patients.The ketogenic diet normalized concentrations of the colonic microbiome after 6 months.

Ginger Improves Symptoms of Ulcerative Colitis, Enhances Quality of Life Bowel and digestive problems like ulcerative colitis can be among the most discomforting and disruptive affronts to a person's lifestyle and overall well-being. What if adding a healthy dose of ginger to your diet could prevent indigestion, inflamed insides and even protect you from colon and rectal cancers? The evidence says, it can

Biomedical engineers have shown how colon cancer development is intricately linked to a specific microRNA that dictates how cells divide. The new study points to a link between chronic gut inflammation and an increased risk of colon cancer. That link could not only serve as an early warning signal of colon cancer, but potentially be harnessed to counteract advanced forms of the disease.

Salicylic acid, the anti-cancer compound in aspirin, is also found in fruits, vegetables, whole grains, nuts, herbs, spices, teas, and even honey.

Abstract. Although smoking cessation is the primary goal for the control of cancer and other smoking-related diseases, chemoprevention provides a complementary

Gastrointestinal cancer is one of the most common cancers globally. Melatonin, a natural endogenous body hormone, has been of interest for years, due …

Glutathione (GSH) deficiency is associated with numerous pathlogical conditions. Administration of N-acetylcysteine (NAC), a cysteine prodrug, replenishes intracellular GSH levels. NAC, best known for it ability to counter acetaminophen toxicity, is a ...

This investigation is part of an effort to develop chemoprevention for carcinogenesis of the large bowel. The agent investigated is N-acetylcysteine (NAC). We used as a predictive biomarker, the proliferative index (PI), in a short-term human study. Patients with previous adenomatous colonic polyps …

Supplement Facts & Directions Supplement Facts Serving Size: 750 milligrams Servings Per Container: Varies Amount Per Serving % Daily Value* N-Acetyl L-Cysteine 750 mg † * Percent Daily Values are based on a 2,000 calorie diet.† Daily Value Not Established ‡ These supplement facts may vary from the product you receive.    Please call for exact numbers. Other Ingredients: None Contains: Free of:  Sugar, Soy, Dairy, Yeast, Gluten, Corn & Additives. Directions:  As a dietary supplement, take 750 mg (3/16 tsp) up to two times daily, or as directed by a physician. Accurate gram weight scale recommended. Warning: If you are pregnant, nursing, taking any medications or have any medical condition consult your physician before use. DO NOT use with heart medications. Keep out of reach of children. READ MORE BELOW Product Details N-acetyl L-cysteine (also known as NAC and acetylcysteine) is the

Let’s talk about a natural way to get rid of polyps which are little growths that can occur in many places in the body. Polyps can occur on the vocal cords, nasal passages, colon, and bladder and many other places. We are going to discuss a natural way to get rid of polyps but first we need to understand why ... Read More

The processed Aloe vera gel (PAG) contains immunomodulatory polysaccharides, which consists of a mixture of polymer chains of b-(1,4)-linked acetylated galactomannan with different lengths. PAG was shown to inhibit azoxymethane(AOM)-initiated and dextran sodium sulfate(DSS)-promoted colon carcinogenesis model in mice. In the present study, we examined the molecular mechanisms for the inhibition of colitis-associated colon carcinogenesis by PAG. PAG administration significantly inhibited the production of pro-inflammatory cytokines and mediators in the colon. Western blot analysis using the colon extracts showed that PAG administration reduced the activation of NF-kB resulting in the inhibition of iNOS and COX-2 expression. PAG appeared to inhibit NF-kB activation through the PPARγ activation. PAG administration also inhibited the expression and phosphorylation of STAT3, which was known to connect inflammation and cancer. PAG administration also inhibited cell cycle progression-related transcription factors such as the proliferating cell nuclear antigen (PCNA), ERK, cyclin-dependent kinase (CDK) 4 and cyclin D1. In contrast, PAG administration increased the expression of CDX2, which was known to be a tumor suppressor in colorectal cancers. These findings show that PAG suppresses colitis-related colon carcinogenesis by inhibiting both chronic inflammation and cell cycle progression in the colon.

In vivo an ecological network of polysaccharides utilization by gut microbiota is not only an intense competition but also an impressive cooperation p…

Fiber isn’t the only thing our good gut bacteria can eat; starch can also act as a prebiotic. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ This is a follow-up to my video Is the Fiber Theory Wrong?(http://nutritionfacts.org/video/is-the-fiber-theory-wrong) What is this butyrate stuff of which I speak? See: • Bowel Wars: Hydrogen Sulfide vs. Butyrate (http://nutritionfacts.org/video/bowel-wars-hydrogen-sulfide-vs-butyrate/) • Prebiotics: Tending Our Inner Garden (http://nutritionfacts.org/video/prebiotics-tending-our-inner-garden) • Treating Ulcerative Colitis with Diet (http://nutritionfacts.org/video/treating-ulcerative-colitis-with-diet) For videos on optimizing your gut flora, see: • Microbiome: The Inside Story (http://nutritionfacts.org/video/microbiome-the-inside-story) • What’s Your Gut Microbiome Enterotype?http://nutritionfacts.org/video/whats-your-gut-microbiome-enterotype • How to Change Your Enterotype (http://nutritionfacts.org/video/how-to-change-your-enterotype/) More on preventing colon cancer in: • Starving Cancer with Methionine Restriction (http://nutritionfacts.org/video/starving-cancer-with-methionine-restriction/) • Stool pH and Colon Cancer (http://nutritionfacts.org/video/stool-ph-and-colon-cancer/) • Solving a Colon Cancer Mystery (http://nutritionfacts.org/video/solving-a-colon-cancer-mystery/) If you’re eating healthy do you need a colonoscopy? Find out in Should We All Get Colonoscopies Starting at Age 50? (http://nutritionfacts.org/video/should-we-all-get-colonoscopies-starting-at-age-50). When regular starches are cooked and then cooled, some of the starch recrystallizes into resistant starch. For this reason, pasta salad can be healthier than hot pasta and potato salad healthier than a baked potato. Find out more in my next video Getting Starch to Take the Path of Most Resistance (http://nutritionfacts.org/video/Getting-starch-to-take-the-path-of-most-resistance). Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/resistant-starch-and-colon-cancer/ and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/resistant-starch-and-colon-cancer/. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image Credit: Ed Uthman via flickr. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org #coloncancer #hownottodie #drgreger

(2016). Resistant starch reduces colonic and urinary p-cresol in rats fed a tyrosine-supplemented diet, whereas konjac mannan does not. Bioscience, Biotechnology, and Biochemistry: Vol. 80, No. 10, pp. 1995-2000.

Exposure to life stressors exacerbates gastrointestinal conditions, including inflammatory bowel diseases and irritable bowel syndrome, however the me…

The algal polysaccharides laminarin (LAM) and fucoidan (FUC) have potent anti-inflammatory activities in the gastrointestinal tract. Our objective was to examine the impact of prior consumption of LAM and/or FUC on pathology and inflammation following ...

Summary. Background: Fucoidan, an antithrombotic polysaccharide, can induce endothelial colony-forming cells (ECFC) to adopt an angiogenic phenotype in vitro. Objectives: We evaluated the effect of...

A leading cause of cancer deaths worldwide, colon cancer is famously resistant to treatment. Now the biological pathway behind the growth of colon cancer has been discovered by researchers who have been able block it with vitamin A.

Eating walnuts may change gut bacteria in a way that suppresses colon cancer, researchers report. A team of researchers found that mice that ate 7-10.5 percent of their total calories as walnuts developed fewer colon cancers. The effect was most pronounced in male mice, which had 2.3 times fewer tumors when fed walnuts as part of a diet similar to the typical American's.

Antiparasitic Drug Ivermectin Has Remarkable Anti-Cancer Activity.

Millions of women undergo them annually, but few are even remotely aware of just how many dangers they are exposing themselves to in the name of prevention, not the least of which are misdiagnosis, overdiagnosis and the promotion of breast cancer itself.

Millions equate a breast cancer diagnosis with a possible death sentence, doing anything from removing their breasts (and ovaries) with added radiation and chemotherapy treatments, when, in fact, the truth is much more forgiving.

A disturbing new study published in the New England Journal of Medicine has brought mainstream attention to the fact that mammography screenings have caused millions of US women to suffer unnecessary surgeries and chemotherapy and radiation treatments over the past 30 years.

Most women are just being told what to do, rather than being given the facts necessary to make a fully informed decision. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ I think I do a pretty good job in the video explaining why I decided to take on this topic. There’s just so much confusion combined with the corrupting commercial interests of a billion dollar industry. As with any important health decision, everyone should be fully informed of the risks and benefits and make up their own mind about their own bodies. That’s why I created this 14 part video series. So that NutritionFacts.org isn’t all-mammograms-all-the-time for weeks, we’re only going to run a few of these back-to-back at a time, interspersing them our “regularly scheduled programming.” Please give us feedback as to whether I should continue to do more of these deep dives or you prefer more superficial coverage across a greater variety of topics (or if we’ve hit the perfect Goldilocks mix!). Stay tuned for the rest of the videos in this 14-part series: • Mammogram Recommendations - Why the Conflicting Guidelines (http://nutritionfacts.org/video/Mammogram-Recommendations-Why-the-Conflicting-Guidelines) • Should Women Get Mammograms Starting at Age 40? (http://nutritionfacts.org/video/Should-Women-Get-Mammograms-Starting-at-Age-40) • Do Mammograms Save Lives? (http://nutritionfacts.org/video/Do-Mammograms-Save-Lives) • Consequences of False-Positive Mammogram Results (http://nutritionfacts.org/video/Consequences-of-False-Positive-Mammogram-Results) • Do Mammograms Hurt? (http://nutritionfacts.org/video/Do-Mammograms-Hurt) • Can Mammogram Radiation Cause Breast Cancer? (http://nutritionfacts.org/video/Can-Mammogram-radiation-Cause-Breast-Cancer) • Understanding the Mammogram Paradox (http://nutritionfacts.org/video/Understanding-the-Mammogram-Paradox) • Overtreatment of Stage 0 Breast Cancer DCIS (http://nutritionfacts.org/video/Overtreatment-of-Stage-0-Breast-Cancer-DCIS) • Women Deserve to Know the Truth About Mammograms (http://nutritionfacts.org/video/Women-Deserve-to-Know-the-Truth-About-Mammograms) • Breast Cancer and the 5-Year Survival Rate Myth (http://nutritionfacts.org/video/breast-Cancer-and-the-5-Year-Survival-Rate-Myth) • Why Mammograms Don’t Appear to Save Lives (http://nutritionfacts.org/video/Why-Mammograms-Don) • Why Patients Aren’t Informed About Mammograms (http://nutritionfacts.org/video/Why-Patients-Arent-Informed-About-Mammograms) • The Pros and Cons of Mammograms (http://nutritionfacts.org/video/The-Pros-and-Cons-of-Mammograms) I was able to fit colon cancer screening into just one video if you can believe it! Here you go if you missed it: Should We All Get Colonoscopies Starting at Age 50? (https://nutritionfacts.org/video/should-we-all-get-colonoscopies-starting-at-age-50/). Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/9-out-of-10-women-misinformed-about-mammograms and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/9-out-of-10-women-misinformed-about-mammograms. You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Captions for this video are available in several languages. To find yours, click on the settings wheel on the lower-right of the video and then "Subtitles/CC." Do you have feedback about the translations in this video? Please share it here along with the title of the video and language: https://nutritionfacts.zendesk.com/hc/requests/new To view the subtitles in transcript format, click on the ellipsis button below the video, choose "Open transcript", and select the language you'd like to view them in. Image credit: KOMUnews / flickr https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

The truth is mammograms just don’t work. Mammograms are dangerous hurting women more than helping them yet doctors and their parent organizations just don’t want to get the message