This study was conducted to evaluate the effectiveness of fucoidan in ameliorating hydrogen peroxide (H2O2)-induced oxidative stress to porcine intestinal epithelial cell line (IPEC-1). The cell viability test was initially performed to screen out appropriate concentrations of H2O2 and fucoidan. After that, cells were exposed to H2O2 in the presence or absence of pre-incubation with fucoidan. Hydrogen peroxide increased the apoptotic and necrotic rate, boosted reactive oxygen species (ROS) generation, and disturbed the transcriptional expression of genes associated with antioxidant defense and apoptosis in IPEC-1 cells. Pre-incubation with fucoidan inhibited the increases in necrosis and ROS accumulation induced by H2O2. Consistently, in the H2O2-treated IPEC-1 cells, fucoidan normalized the content of reduced glutathione as well as the mRNA abundance of NAD(P)H quinone dehydrogenase 1 and superoxide dismutase 1 while it prevented the overproduction of malondialdehyde. Moreover, H2O2 stimulated the translocation of nuclear factor-erythroid 2-related factor-2 to the nucleus of IPEC-1 cells, but this increase was further promoted by fucoidan pre-treatment. The results suggest that fucoidan is effective in protecting IPEC-1 cells against oxidative damage induced by H2O2, which may help in developing appropriate strategies for maintaining the intestinal health of young piglets.

Can tattoos embrace technology in order to make the skin interactive?The DermalAbyss project was the result of a collaboration between MIT researchers Katia ...

Chitosan, fucoidan, and polyvinyl alcohol are categorized as polymers with biomedical applications. Ampicillin, on the other hand, is considered as an important antibiotic that has shown effectivity in both gram-positive and gram-negative micro-organisms. The aforementioned polymers possess unique p …

The deleterious effects of a Paleolithic diet appear to undermine the positive effects of a Crossfit-based high-intensity circuit training exercise program.

The human body has over 60 trillion cells, and every one of them is vulnerable to the development of multiple diseases. One of the biggest problems facing medicine is how to diagnose these diseases earlier, in order to improve the chances of stopping and reversing them.

The marine acid polysaccharide fucoidan has attracted attention from both the food and pharmaceutical industries due to its promising therapeutic effects. Fucoidan is a polysaccharide that mainly consists of L-fucose and sulphate groups. Its excellent biological function is attributed to its unique …

Repeat BCG Vaccinations for the Treatment of Established Type 1 Diabetes - Full Text View.

Dr. Faustman shares exciting news about the Phase II Studies being done to reverse type 1 diabetes with the BCG vaccine. The BCG vaccine is a generic vaccine and is one of the most widely used vaccines in the world. Watch this exciting interview to learn if the BCG vaccine offers hope to those with type 2 diabetes, fibromyalgia, and cystic fibrosis. Support one of the most significant cures of this century! You can make a difference. Donate today!

The incidence of diabetes mellitus is rapidly increasing throughout the world. Although the exact cause of the disease is not fully clear, perhaps, genetics, ethnic origin, obesity, age, and lifestyle are considered as few of many contributory factors for the disease pathogenesis. In recent years, the disease progression is particularly linked with functional and taxonomic alterations in the gastrointestinal tract microbiome. A change in microbial diversity, referred as microbial dysbiosis, alters the gut fermentation profile and intestinal wall integrity and causes metabolic endotoxemia, low-grade inflammation, autoimmunity, and other affiliated metabolic disorders. This article aims to summarize the role of the gut microbiome in the pathogenesis of diabetes. Additionally, we summarize gut microbial dysbiosis in preclinical and clinical diabetes cases reported in literature in the recent years.

Fucoidans extracted from brown algae have been documented to have excellent antithrombotic activity when administered by either intravenous or subcutaneous route in animal models. However, it is unknown if the fucoidans also have antithrombotic activity when administered orally, a highly desirable feature of oral antithrombotic agents. In the present study, we compared the oral absorption, bioavailability and antithrombotic activity of two fucoidan fractions from Laminaria japonica with different molecular weight by oral administration in an electricity induced arterial thrombosis model and the underlying molecular mechanisms.

One Drop has acquired all the assets and intellectual property of Sano Intelligence, Inc., which include Sano’s continuous glucose sensing platform NEW YORK, NY, April 13, 2020 — One Drop, a leader in digital care solutions for people living with diabetes and other chronic conditions, today announced it has acquired all of the assets and intellectual property of Sano Intelligence, Inc., an innovator in health sensing technology. The deal was structured as an asset purchase, and several Sano team members will be joining One Drop. The almost decade of work put into developing the Sano continuous glucose sensing platform will live on in a comprehensive multi-sensorial solution from One Drop. The planned development marks a significant milestone in One Drop’s effort to bring personalized, adaptive, integrated health solutions to people in real time via their mobile phones. One Drop will leverage the acquired assets, including silicon-sensing production infrastructure, to design, produce, and commercialize a painless, silicon-based continuous health sensing platform for use across multiple conditions. “Sano and One Drop have a shared vision of transforming traditional healthcare into proactive, preventative self-care,

Diabetic kidney disease, diagnosed by urinary albumin excretion rate (AER), is a critical symptom of chronic vascular injury in diabetes, and is associated with dyslipidemia and increased mortality. We investigated serum lipids in 326 subjects with type 1 diabetes: 56% of patients had normal AER, 17% had microalbuminuria (20 ≤ AER < 200 μg/min or 30 ≤ AER < 300 mg/24 h) and 26% had overt kidney disease (macroalbuminuria AER ≥ 200 μg/min or AER ≥ 300 mg/24 h). Lipoprotein subclass lipids and low-molecular-weight metabolites were quantified from native serum, and individual lipid species from the lipid extract of the native sample, using a proton NMR metabonomics platform. Sphingomyelin (odds ratio 2.53, P < 10−7), large VLDL cholesterol (odds ratio 2.36, P < 10−10), total triglycerides (odds ratio 1.88, P < 10−6), omega-9 and saturated fatty acids (odds ratio 1.82, P < 10−5), glucose disposal rate (odds ratio 0.44, P < 10−9), large HDL cholesterol (odds ratio 0.39, P < 10−9) and glomerular filtration rate (odds ratio 0.19, P < 10−10) were associated with kidney disease. No associations were found for polyunsaturated fatty acids or phospholipids. Sphingomyelin was a significant regressor of urinary albumin (P < 0.0001) in multivariate analysis with kidney function, glycemic control, body mass, blood pressure, triglycerides and HDL cholesterol. Kidney injury, sphingolipids and excess fatty acids have been linked in animal models—our exploratory approach provides independent support for this relationship in human patients with diabetes.

Sugar is hiding everywhere in today's widely-accepted diet, but meanwhile its devastating effects are creating more deaths than automobile accidents. In this eye-opening talk, Dr. Jody Stanislaw, a Naturopathic Doctor who has been studying the negative effects of sugar since being diagnosed with type 1 diabetes at the age of 7, dives into how the widespread negative effects of sugar are effecting us all, and what you can do about it. Dr. Jody Stanislaw received her Doctorate in Naturopathic Medicine in 2007. She is a Certified Diabetes Educator, Type 1 Diabetes Specialist, and a founding board member of the Low Carb Diabetes Association. Having lived with Type 1 Diabetes since the age of seven, she has dedicated her career to helping others with Type 1. From her 30+ years of experience, she teaches life-changing information about how to successfully manage Type 1 that most physicians have never learned, and the millions struggling with Type 1 desperately need to know. Patients from over thirty states and ten countries have worked with her via her virtual practice. Yet there are millions around the world still struggling. To tackle this gap, she will soon be launching the first-ever, Type 1 diabetes virtual training course, with the goal of improving the lives of millions of Type 1’s around the world. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx

Medical Disclaimer - Medical Disclaimer - *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association. He is also a Diplomate with the American Clinical Board of Nutrition.

Whole plant sources of sugar and fat can ameliorate some of the postprandial inflammation caused by the consumption of refined carbs and meat. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ Meat protein can cause more of an insulin spike than pure table sugar. See the comparisons in my video Paleo Diets May Negate Benefits of Exercise (http://nutritionfacts.org/video/paleo-diets-may-negate-benefits-of-exercise/). I discussed the almond butter study in my last video, How to Prevent Blood Sugar and Triglyceride Spikes after Meals (http://nutritionfacts.org/video/How-to-Prevent-Blood-Sugar-and-Triglyceride-Spikes-after-Meals). Berries have sugar of their own in them, so how can eating berries lower the blood sugar spike to a meal? Find out in If Fructose is Bad, What About Fruit? (http://nutritionfacts.org/video/if-fructose-is-bad-what-about-fruit). More videos on avocadoes coming up and here’s more on red wine: • Breast Cancer Risk: Red Wine v. White Wine (http://nutritionfacts.org/video/breast-cancer-risk-red-wine-vs-white-wine/) • Resveratrol Impairs Exercise Benefits (http://nutritionfacts.org/video/resveratrol-impairs-exercise-benefits/) • How to Treat High Blood Pressure with Diet (http://nutritionfacts.org/video/how-to-treat-high-blood-pressure-with-diet/) Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/effects-of-avocados-and-red-wine-on-meal-induced-inflammation and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/effects-of-avocados-and-red-wine-on-meal-induced-inflammation. You’ll also find a transcript of the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image credit: Kristina DeMuth. Image has been modified. Icons created by Myart, H. Alberto Gongora, Sergey Demushkin, Made in France, Anton Noskov, and Creative Stall from the Noun Project. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Dietary tips for type 1 diabetic patients center on supplying carbs to balance insulin dosage. Our guest today, Dr. Keith Runyan, challenges this approach.

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Epigenetics is defined as mitotically heritable changes in gene expression that do not directly alter the DNA sequence. By implication, such epigenetic changes are non-genetically determined, although they can be affected by inherited genetic variation. ...

Type 1 diabetes (T1DM) affects approximately 1 in 500 children. Diabetic peripheral neuropathy (DPN) is the most common form of peripheral neuropathy …

What if the long sought after "cure" for diabetes was as safe, affordable, and accessible as a spice sitting in your kitchen cupboard?

In this study, we observed that brown seaweed fucoidan inhibited human breast cancer progression by upregulating microRNA (miR)-29c and downregulating miR-17-5p, thereby suppressing their target genes, a disintegrin and metalloproteinase 12 (ADAM12) and ...