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Protective effect of vitamin C against ivermectin induced nephrotoxicity in different age groups of male wistar rats: bio-histopathological study - PMC
Ivermectin (Ive) has exceedingly efficient against several microorganisms including viruses; therefore, it could help as a potential treatment of COVID-19. Because of increasing consumption of ivermectin and vitamin C (Vit.C) in hope to treat ...
FDA To Delete Ivermectin Posts - YouTube
FDA To Delete Ivermectin PostsFDA has agreed to remove Ivermectin and COVID related posts from their site, X, Facebook, LinkedIn, etc. Let’s review the repor...
FDA BACKTRACKS ON IVERMECTIN - The HighWire
After years of attacks, the FDA has admitted in court that doctors have the right to prescribe Ivermectin. We take a deep look at one of the largest smear campaigns in modern history against a promising therapy. Why did so few medical professionals ignore this early treatment against the warnings of preeminent physicians like Dr. […]
Ivermectin, ‘Wonder drug’ from Japan: the human use perspective - PMC
Discovered in the late-1970s, the pioneering drug ivermectin, a dihydro derivative of avermectin—originating solely from a single microorganism isolated at the Kitasato Intitute, Tokyo, Japan from Japanese soil—has had an immeasurably ...
The Pharmacokinetics and Interactions of Ivermectin in Humans—A Mini-review - PMC
Ivermectin is an antiparasitic drug with a broad spectrum of activity, high efficacy as well as a wide margin of safety. Since 1987, this compound has a widespread use in veterinary medicine and it use has been extended in humans. Here we present a brief ...
Cureus | Ivermectin Prophylaxis Used for COVID-19: A Citywide, Prospective, Observational Study of 223,128 Subjects Using Propensity Score Matching | Article
Background: Ivermectin has demonstrated different mechanisms of action that potentially protect from both coronavirus disease 2019 (COVID-19) infection and COVID-19-related comorbidities. Based ...
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FDA Says Ivermectin Doesn’t Work Against COVID-19 but Points to Studies That Show It Does
The U.S. Food and Drug Administration (FDA) says a drug called ivermectin does not work against COVID-19 but ...
Could the COVID-19-Driven Increased Use of Ivermectin Lead to Incidents of Imbalanced Gut Microbiota and Dysbiosis - PMC
The microfilaricidal anthelmintic drug ivermectin (IVM) has been used since 1988 for treatment of parasitic infections in animals and humans. The discovery of IVM’s ability to inactivate the eukaryotic importin α/β1 heterodimer ...
HOW DID IVERMECTIN WIN THE NOBEL PRIZE - The HighWire
Pierre Kory, MD, breaks down the incredible global health impact of ivermectin that led to the awarding of the Nobel Prize in 2015. #GetFactsinated #PierreKory #Ivermectin POSTED: August 30, 2022
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WHAT IS IVERMECTIN AND WHERE DOES IT COME FROM - The HighWire
President of Front Line Covid-19 Critical Care, Pierre Kory, MD, explains ivermectin’s origin, from a microorganism discovered on a golf course in Japan, to a powerful antiparasitic. #GetFactsinated #PierreKory #Ivermectin POSTED: August 30, 2022
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New Study Confirms Ivermectin Outperforms Other Options
Tested on the Omicron variant, ivermectin outperformed 10 medications, including one approved for emergency use. Early treatment can ...
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DR PIERRE KORY EXPOSES THE IVERMECTIN SCANDAL - The HighWire
POSTED: February 14, 2022
Insights from a computational analysis of the SARS-CoV-2 Omicron variant Host-pathogen interaction, pathogenicity and possible therapeutics
Prominently accountable for the upsurge of COVID-19 cases as the world attempts to recover from the previous two waves, Omicron has further threatened the conventional therapeutic approaches....
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When it comes to the treatment of COVID-19, many Western nations have been hobbled by the politicization of ...
Ivermectin Docks to the SARS-CoV-2 Spike Receptor-binding Domain Attached to ACE2 - PubMed
The ivermectin docking we identified may interfere with the attachment of the spike to the human cell membrane. Clinical trials now underway should determine whether ivermectin is an effective treatment for SARS-Cov2 infection.
Dying COVID-19 Patient Recovers After Court Orders Hospital to Administer Ivermectin
An elderly COVID-19 patient has recovered after a court order allowed him to be treated with ivermectin, despite ...
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Nebraska AG Gives Green Light To Ivermectin NaturalHealth365
(NaturalHealth365) Nebraska AG allows doctors to prescribe ivermectin and hydroxychloroquine for COVID-19. Will other states follow?
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Link to featured video
https://www.youtube.com/watch?v=ctwX1cz_-dw&t=323s
Link to Wefwafwa’s channel
https://www.youtube.com/channel/UCzsLklGgOttU3Se-WGLp7ow
(he needs more subscribers)
Link to support Wefwafwa’s work in Africa
patreon:https://www.patreon.com/awmedicalvideos
Drugs Shown to Inhibit SARS-CoV-2 in COVID-19 Disease: Comparative Basic and Clinical Pharmacology of Molnupiravir and Ivermectin
https://austinpublishinggroup.com/pharmacology-therapeutics/fulltext/ajpt-v9-id1149.pdf
https://www.linkedin.com/in/leslie-adesuyi-ajayi-md-phd-fbpharmacols-fwacp-69154a38/
There are still many nations where vaccines are not yet widely available,
There is a gradual shift in focus, to antiviral drugs,
Adjunctive chemoprophylaxis
Active treatment of new SARS-CoV-2 infections
Post -vaccination breakthrough COVID-19 cases
The two ways to get new drugs
Develop novel antiviral drugs for SARS-CoV-2
Repurpose existing FDA -approved drugs to treat COVID-19
Ivermectin is the most studied “repurposed” medication globally,
in randomized clinical trials, retrospective studies and meta- analyses.
Molnupiravir and Ivermectin Anti-SARS- CoV-2 Mechanisms, Pharmacokinetics and Pharmacodynamics
Molnupiravir is a broad spectrum antiviral agent against SARS- CoV-2, SARS-CoV,
seasonal or pandemic influenza and MERS corona virus
Ivermectin is an FDA-approved, WHO essential drug used as broad spectrum antiparasitic, antibiotic
and which has demonstrated broad spectrum antiviral activity against RNA viruses, including HIV, Zika, MERS corona virus
The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro
https://www.sciencedirect.com/science/article/pii/S0166354220302011
5000-fold inhibition of SARS-CoV-2, (99.98% at 48 hours
The inhibitory concentration IC50 of Molnupiravir shows it to be a more potent anti-SARS-CoV-2 agent, compared to Ivermectin in vitro.
Both molnupiravir and ivermectin are well absorbed after oral dosing
Tmax of molnupiravir being 1-1.75 hours,
With a half life of 7 hours
Tmax of ivermectin is 4-6 hours
Very long half life of 81-91 hours
Ivermectin, being lipophilic has a large volume of distribution
Ivermectin has the ability to accumulate in the lungs
The anti-SARS-CoV-2 actions, both of molnupiravir and ivermectin, are dose and concentration dependent
Molnupiravir active metabolite (NHC-5’ Triphosphate), acts as a competitive alternative substrate for viral RNA
causing viral mutagenesis or mutations, which leads to viral error catastrophe and extinction of replication
There is some concern about the safety of NHC -nucleoside triphosphate, which is also mutagenic to mammalian cells
Ivermectin, multifarious actions,
Binding to SARS-CoV-2 spike protein S
Reducing cell entry via human ACE2 receptors
Reducing viral transcription
Inhibition of cytokine production and inflammation
(not yet been shown for molnupiravir)
Complimentary pharmacokinetics and pharmacodynamics of the drugs
May be additive or synergistic
This should be further investigated in anti-SARS- CoV-2 antiviral combination therapy.
A combination of molnupiravir with Ivermectin putatively, in effects on RdRP or cytokine release.
Cost
https://www.who.int/selection_medicines/committees/expert/21/reviews/Ivermectin_Review1.pdf
The cost for a package of 100 tablets of 3 mg ivermectin is $2.96.
Say, 12mg per day for 5 days = $0.53
Safety
http://www.vigiaccess.org
https://www.who-umc.org/vigibase/vigibase/
Efficacy
Ivermectin
https://pubmed.ncbi.nlm.nih.gov/34145166/
For deaths, average risk ratio 0.38, (62% benefit) (moderate-certainty evidence
https://ivmmeta.com
Early treatment
Late treatment
Prophylaxis
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD015017.pub2/epdf/full
Main results, Treating people in hospital with COVID-19
We don't know whether ivermectin compared with placebo or usual care, 28 days after treatment:–
leads to more or fewer deaths
worsens or improves patients' condition assessed by need for ventilation or oxygen
increases or reduces unwanted events
Preventing COVID-19
We don't know whether ivermectin leads to more or fewer deaths compared with no drug