2016

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VPN: Shield or sham?
VPN: Shield or sham?
The Friday Chat: Every Friday, we take one technology topic and explore it properly. Read it. Think about it. Join the conversation.
·softmaker.com·
VPN: Shield or sham?
Cancer & Metabolic Healing | Substack
Cancer & Metabolic Healing | Substack
The treatment of Cancer and Metabolic diseases using diet, repurposed pharmaceuticals, and targeted nutraceuticals. Click to read Cancer & Metabolic Healing, a Substack with tens of thousands of subscribers.
·paulmarik.substack.com·
Cancer & Metabolic Healing | Substack
Genetic–Epigenetic Interplay in Epilepsy: Pathways, Biomarkers, and Epigenome-Targeted Therapies | MDPI
Genetic–Epigenetic Interplay in Epilepsy: Pathways, Biomarkers, and Epigenome-Targeted Therapies | MDPI
Epilepsy is a heterogeneous neurological disorder with a strong genetic basis, yet recent evidence underscores the critical role of epigenetic mechanisms in its pathogenesis. This review synthesizes current knowledge on how chromatin remodeling, histone modifications, DNA methylation, and transcriptional regulation intersect with classical channelopathies and signaling pathways. We emphasize how epigenetic dysregulation contributes to neuronal excitability and network plasticity, particularly through interactions with mTOR, PI3K-AKT, and GABAergic signaling cascades. The convergence of genetic mutations and epigenetic modifications creates a dynamic landscape in which environmental factors can modify gene expression and contribute to the development of epilepsy. Emerging therapeutic strategies—including epigenetic drugs (HDAC inhibitors, DNMT inhibitors), CRISPR/dCas9-based epigenome editing, and multi-omics approaches—offer promising avenues for precision medicine. This review provides a comprehensive synthesis of genetic and epigenetic mechanisms in epilepsy, examining how these layers interact to produce disease phenotypes and discussing the therapeutic implications of this multilayered regulation.
·mdpi.com·
Genetic–Epigenetic Interplay in Epilepsy: Pathways, Biomarkers, and Epigenome-Targeted Therapies | MDPI
Palm Sunday and the Precision of Prophecy - YouTube
Palm Sunday and the Precision of Prophecy - YouTube
Shalom everyone. On this Palm Sunday, it is essential to recognize that the Triumphal Entry was not merely a historical tradition, but the literal fulfillmen...
·youtube.com·
Palm Sunday and the Precision of Prophecy - YouTube