2016

Glucose and glucose metabolites are able to adversely modify proteins through a non-enzymatic reaction called glycation, which is associated with the pathology of Alzheimer’s Disease (AD) and is a characteristic of the hyperglycaemia induced by diabetes. However, the precise protein glycation profile that characterises AD is poorly defined and the molecular link between hyperglycaemia and AD is unknown. In this study, we define an early glycation profile of human brain using fluorescent phenylboronate gel electrophoresis and identify early glycation and oxidation of macrophage migration inhibitory factor (MIF) in AD brain. This modification inhibits MIF enzyme activity and ability to stimulate glial cells. MIF is involved in immune response and insulin regulation, hyperglycaemia, oxidative stress and glycation are all implicated in AD. Our study indicates that glucose modified and oxidised MIF could be a molecular link between hyperglycaemia and the dysregulation of the innate immune system in AD.

Transgenic mice with increased amyloid-β (Aβ) production show several aspects of Alzheimer’s disease, including Aβ deposition and memory impairment. By repeatedly treating these Aβ-forming mice with scanning ultrasound, Leinenga and Götz now demonstrate that Aβ is removed and memory is restored as revealed by improvement in three memory tasks. These improvements were achieved without the use of any therapeutic agent, and the scanning ultrasound treatment did not induce any apparent damage to the mouse brain. The authors then showed that scanning ultrasound activated resident microglial cells that took up Aβ into their lysosomes. These findings suggest that repeated scanning ultrasound may be a noninvasive method with potential for treating Alzheimer’s disease. Amyloid-β (Aβ) peptide has been implicated in the pathogenesis of Alzheimer’s disease (AD). We present a nonpharmacological approach for removing Aβ and restoring memory function in a mouse model of AD in which Aβ is deposited in the brain. We used repeated scanning ultrasound (SUS) treatments of the mouse brain to remove Aβ, without the need for any additional therapeutic agent such as anti-Aβ antibody. Spinning disk confocal microscopy and high-resolution three-dimensional reconstruction revealed extensive internalization of Aβ into the lysosomes of activated microglia in mouse brains subjected to SUS, with no concomitant increase observed in the number of microglia. Plaque burden was reduced in SUS-treated AD mice compared to sham-treated animals, and cleared plaques were observed in 75% of SUS-treated mice. Treated AD mice also displayed improved performance on three memory tasks: the Y-maze, the novel object recognition test, and the active place avoidance task. Our findings suggest that repeated SUS is useful for removing Aβ in the mouse brain without causing overt damage, and should be explored further as a noninvasive method with therapeutic potential in AD.

Although the potential contribution of the human gastrointestinal (GI) tract microbiome to human health, aging, and disease is becoming increasingly acknowledged, the molecular mechanics and signaling pathways of just how this is accomplished is not well-understood. Major bacterial species of the GI tract, such as the abundant Gram-negative bacilli Bacteroides fragilis (B. fragilis) and Escherichia coli (E. coli), secrete a remarkably complex array of pro-inflammatory neurotoxins which, when released from the confines of the healthy GI tract, are pathogenic and highly detrimental to the homeostatic function of neurons in the central nervous system (CNS). For the first time here we report the presence of bacterial lipopolysaccharide (LPS) in brain lysates from the hippocampus and superior temporal lobe neocortex of Alzheimer's disease (AD) brains. Mean LPS levels varied from two-fold increases in the neocortex to three-fold increases in the hippocampus, AD over age-matched controls, however some samples from advanced AD hippocampal cases exhibited up to a 26-fold increase in LPS over age-matched controls. This “Perspectives” paper will further highlight some very recent research on GI tract microbiome signaling to the human CNS, and will update current findings that implicate GI tract microbiome-derived LPS as an important internal contributor to inflammatory degeneration in the CNS.

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In one of the largest microbiota studies conducted in humans, researchers have shown a potential link between healthy aging and a healthy gut.

Research has concluded that a healthy diet rich in antioxidants and anti-inflammatory natural substances can increase longevity and improve the aging process

It may come as a surprise to some, especially those with conventional medical training, but the default state of the body is one of ceaseless regeneration. Without the flame-like persistence of continual cell turnover within the body - life and death ceaselessly intertwined - the miracle of the human body would not exist

Research in C. elegans shows the popular supplement vitamin D engages longevity genes to increase lifespan and prevent the accumulation of toxic proteins linked to many age-related diseases.

Human beings are subjected to aging and age-associated diseases. Life expectancy has improved impressively in the last century due to social and economic development, but despite increasing improvement is still more limited than average in those ones ...

Dr. Nun S. Amen-Ra. Official site of the Architekton's services and Archives, including AIR, M4, and EN.

Only about 1 in 10,000 people make it to be a 100 years old. What’s their secret? Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ The IGF-1 story is so pivotal, that it’s one of the first video series I ever did on NutritionFacts.org. I’m so glad to finally get around to the long awaited update. If you want a blast from the past, you can see the original series starting with Engineering a Cure (http://nutritionfacts.org/video/engineering-a-cure/). For more parallels between the tobacco industry and the food industry, see: • American Medical Association Complicity with Big Tobacco (http://nutritionfacts.org/video/american-medical-association-complicity-big-tobacco/) • The Healthy Food Movement: Strength in Unity (http://nutritionfacts.org/video/the-healthy-food-movement-strength-in-unity/) • Evidence-Based Nutrition (http://nutritionfacts.org/video/evidence-based-nutrition/) • Big Food Using the Tobacco Industry Playbook (http://nutritionfacts.org/video/big-food-using-the-tobacco-industry-playbook/) For more on healthy aging and longevity, see: • Increased Lifespan from Beans (http://nutritionfacts.org/video/increased-lifespan-from-beans/) • Caloric Restriction vs. Animal Protein Restriction (http://nutritionfacts.org/video/caloric-restriction-vs-animal-protein-restriction/) • The Okinawa Diet: Living to 100 (http://nutritionfacts.org/video/the-okinawa-diet-living-to-100) • Methionine Restriction as a Life Extension Strategy (http://nutritionfacts.org/video/methionine-restriction-as-a-life-extension-strategy/) • Do Flexitarians Live Longer? (http://nutritionfacts.org/video/do-flexitarians-live-longer) Note the so-called “low” protein intake is actually the recommended protein intake, associated with a major reduction in cancer and overall mortality in middle age, under age 65, but note it says not among older individuals. All covered in my next video, Increasing Protein Intake After Age 65 (http://nutritionfacts.org/video/Increasing-protein-intake-after-age-65). Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/animal-protein-compared-to-cigarette-smoking and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/animal-protein-compared-to-cigarette-smoking. You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image Credit: gholem via Pixabay. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Take a look, using Dr. Sircus as an example, how is Natural Allopathic Medicine protocol, and especially hydrogen, can not only reverse disease conditions but make one look and feel young again.

Objectives To evaluate the associations of regular glucosamine use with all-cause and cause-specific mortality in a large prospective cohort. Methods This population-based prospective cohort study included 495 077 women and men (mean (SD) age, 56.6 (8.1) years) from the UK Biobank study. Participants were recruited from 2006 to 2010 and were followed up through 2018. We evaluated all-cause mortality and mortality due to cardiovascular disease (CVD), cancer, respiratory and digestive disease. HRs and 95% CIs for all-cause and cause-specific mortality were calculated using Cox proportional hazards models with adjustment for potential confounding variables. Results At baseline, 19.1% of the participants reported regular use of glucosamine supplements. During a median follow-up of 8.9 years (IQR 8.3–9.7 years), 19 882 all-cause deaths were recorded, including 3802 CVD deaths, 8090 cancer deaths, 3380 respiratory disease deaths and 1061 digestive disease deaths. In multivariable adjusted analyses, the HRs associated with glucosamine use were 0.85 (95% CI 0.82 to 0.89) for all-cause mortality, 0.82 (95% CI 0.74 to 0.90) for CVD mortality, 0.94 (95% CI 0.88 to 0.99) for cancer mortality, 0.73 (95% CI 0.66 to 0.81) for respiratory mortality and 0.74 (95% CI 0.62 to 0.90) for digestive mortality. The inverse associations of glucosamine use with all-cause mortality seemed to be somewhat stronger among current than non-current smokers (p for interaction=0.00080). Conclusions Regular glucosamine supplementation was associated with lower mortality due to all causes, cancer, CVD, respiratory and digestive diseases.

With the recent rise in popularity of naturally-derived supplements to maintain a healthy body, there has been a great deal of attention toward development of the so-called "brain foods", which can enhance brain function. Of particular importance is the natural red pigment astaxanthin (ASX) abundant in both salmon and in crustaceans such as shrimp and crab. ASX has a powerful antioxidant effect, and is capable of penetrating the blood-brain barrier, entering the brain, where it acts directly on nerve cells. ASX is also known to have a neuroprotective effect. However, there are many unanswered questions as to the effects of ASX on hippocampal function, especially whether or not it can increase the neuroplasticity of the hippocampus.

There is a food that offers the best of both worlds, significantly improving our ability to detox carcinogens like diesel fumes and decreasing inflammation in our airways all the while improving our respiratory defences against infections. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ I love this video! I’ve been reading about the terrible effects of air pollution for a long time, but finally there’s at least something we can do that doesn’t involve having to uproot your family and move out to the countryside. Prolonged Liver Function Enhancement from Broccoli (http://nutritionfacts.org/video/prolonged-liver-function-enhancement-from-broccoli/) is the previous video I referred to. More cruciferocity here: • Lung Cancer Metastases and Broccoli (http://nutritionfacts.org/video/lung-cancer-metastases-and-broccoli/) • Prolonged Liver Function Enhancement from Broccoli (http://nutritionfacts.org/video/prolonged-liver-function-enhancement-from-broccoli/) • Breast Cancer Survival Vegetable (http://nutritionfacts.org/video/breast-cancer-survival-vegetable/) But there’s a secret to maximizing the benefits. See Second Strategy to Cooking Broccoli (http://nutritionfacts.org/video/second-strategy-to-cooking-broccoli/). What about broccoli sprout pills? see Broccoli: Sprouts vs. Supplements (http://nutritionfacts.org/video/broccoli-sprouts-vs-supplements/). Speaking of respiratory inflammation, what about dietary approaches to asthma? See: • Preventing Asthma With Fruits and Vegetables (http://nutritionfacts.org/video/preventing-asthma-with-fruits-and-vegetables/) • Treating Asthma With Fruits and Vegetables (http://nutritionfacts.org/video/treating-asthma-with-fruits-and-vegetables/) • Treating Asthma With Plants vs. Supplements? (http://nutritionfacts.org/video/treating-asthma-with-plants-vs-supplements/) • Treating Asthma and Eczema with Plant-based Diets (http://nutritionfacts.org/video/treating-asthma-and-eczema-with-plant-based-diets/) • Vitamin D for Asthma (http://nutritionfacts.org/video/vitamin-D-for-asthma) • How to Treat Asthma with a Low Salt Diet (http://nutritionfacts.org/video/How-to-Treat-Asthma-with-a-Low-Salt-Diet) There are sources of indoor pollution too, see Throw Household Products off the Scent (http://nutritionfacts.org/video/throw-household-products-off-the-scent/). There is one way what we eat can directly impact air pollution beyond just personal protection. Check out Diet & Climate Change: Cooking Up a Storm (http://nutritionfacts.org/video/diet-and-climate-change-cooking-up-a-storm/). Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/best-food-to-counter-the-effects-of-air-pollution and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/best-food-to-counter-the-effects-of-air-pollution. You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Image credit: pixakame via pixabay. Image has been modified. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Bioidentical Estrogen Hormones Could Have Saved 50,000 Lives, New Yale Study.

Old mice ran around like young animals again, and showed signs of improved memory, after receiving injections of blood taken from 18-year-old people