2016

Besides taking Cannabis tinctures sublingually, rectal administration is the method with the highest bioavalability. Learn more about Cannabis suppositories

Finding the ideal method of taking cannabis preparations is essential in every patient’s protocol. Lear more on cannabis suppository bioavailability!

The harms caused by human papillomavirus (HPV) vaccination can be complex, severe, and exceedingly difficult to treat. However, a promising new study shows there is hope for those whom conventional medicine has failed.

Low back pain is a common condition affecting many individuals. Cannabis can help. Learn more in our scientific review on cannabis use for sciatica!

Whether or not cannabis use may increase the risk for depression and/or anxiety is not clear. For one thing, it has not been possible to draw a defini…

CBD and THC are the power couple of cannabis therapeutics, interacting to amplify one another’s curative properties. CBD enhances THC’s painkilling and anticancer properties, while lessening THC’s

Many health professionals have little to no experience with cannabis therapeutics and are not able to guide people on this subject. So Project CBD has created a beginner’s guide to cannabidiol &

With CBD becoming widely available, scientists are taking a closer look at CBD-drug interactions.

The seeds of hemp (Cannabis sativa L.) have been an important source of nutrition for thousands of years in Chinese and European cultures but, nowadays, in spite of the multiple clinical evidence, which highlights their huge health-promoting properties, people are still unaware about their nutritional as well as nutraceutical benefits. Indeed, the extraordinary richness of essential polyunsaturated fatty acids is odds with oxidative stability of hemp seed by-products. This is the reason for which different and innovative extractive strategies are daily employed, as well as the preservation of antioxidant hemp seed phenols and polyphenols is claimed as a key issue to pursue. Recent insights into the phenol and cannabinoid baggage of hemp seed highlight it is an inestimable source of health promoting ingredients. This review aims to provide a detailed and updated background for research on seeds of this niche crop, pointing out the chemistry and bioactivity of their phytochemicals.

The recent demonstration that massive scale chromosomal shattering or pulverization can occur abruptly due to errors induced by interference with the …

Multiple Sclerosis (MS), is a common autoimmune disease that affects the central nervous system. Currently, there is no cure for MS, and most treatments involve the use of immunosuppressive drugs that can have adverse effects or increased toxicity. Cannabis, commonly known as marijuana, is a product of the Cannabis sativa , and for several centuries has been used as an alternative medicine in many cultures. Cannabis sativa produces over 421 chemical compounds, including about 80 terpenophenols named phytocannabinoids, and include both psychotropic THC and non-psychoactive CBD. In the currently study, we show that a combination therapy using THC and CBD results in amelioration of EAE, an animal model of MS, by reducing hind limb paralysis, decreasing immune cellular infiltration into the brain, and mitigating the presence of inflammatory biomarkers, including gram negative bacteria-associated lipopolysaccharide (LPS). Interestingly, the gut microbiome plays an important role in immune function and studies have shown that it is altered significantly in MS patients. Inasmuch, we performed 16S rRNA sequencing on experimental groups to investigate the gut microbiome composition after using a combination of THC and CBD compared to disease controls. Interestingly, we found that EAE mice showed increase in the mucin degrading bacterial species, Akkermansia municiphila , which was significantly reduced in disease mice treated with THC+CBD. Collectively, our data suggests that THC+CBD can ameliorate EAE by preventing accumulation of mucin-degrading bacteria that would lead to increased gut microbial dysbiosis.

Walacea is crowdfunding a clinical trial in 30 patients investigating cannabis in the treatment of cancer. Cannabinoids have anti-cancer activity.

Picking the seeds and stems out of the Bible.

Dr David Allen talks to Medical Marijuana 411 about his experience with cannabis, strokes, stroke prevention and the human endocannabinoid system. Dr Allen is one of the featured medical professionals in the Medical Marijuana 411 online education courses for medical professionals, patients and dispensary technicians. This is an example of the video content that is part of the online education. With more thank 800 peer reviewed citations, downloadable graphics, Medical Marijuana 411 is the leader in cannabis education. Check out the entire list of certifications and courses offered at http://www.medicalmarijuana411.com

In this installment of Cannabis Conversations, Dr. Ethan Russo discusses clinical endocannabinoid deficiency and ways to target the endocannabinoid system for therapeutic benefit.

United Patients Group is the leading source for Medical Marijuana & Medical Cannabis Info. Dr. Sulak, Optimal Cannabis Dosing Guidelines Presented by UPG!

After a century of banishment, both euphoric (“marijuana”) and non-euphoric (“industrial hemp”) classes of Cannabis sativa are attracting billions of dollars of investment as new legitimate crops. Most domesticated C. sativa is very tall, a phenotype that is desirable only for hemp fibre obtained from the stems. However, because the principal demands today are for chemicals from the inflorescence and oilseeds from the infructescence, an architecture maximizing reproductive tissues while minimizing stems is appropriate. Such a design was the basis of the greatest short-term increases in crop productivity in the history of agriculture: the creation of short-stature (“semi-dwarf”), high-harvest-index grain cultivars, especially by ideotype breeding, as demonstrated during the “Green Revolution.” This paradigm has considerable promise for C. sativa. The most critical dwarfing character for breeding such productivity into C. sativa is contraction of internodes. This reduces stem tissues (essentially a waste product except for fibre hemp) and results in compact inflorescences (which, on an area basis, maximize cannabinoid chemicals) and infructescences (which maximize oilseed production), as well as contributing to ease of harvesting and efficiency of production on an area basis. Four sources of germplasm useful for breeding semi-dwarf biotypes deserve special attention: (1) Naturally short northern Eurasian wild plants (often photoperiodically day-neutral, unlike like most biotypes) adapted to the stress of very short seasons by maximizing relative development of reproductive tissues. (2) Short, high-harvest-index, oilseed plants selected in northern regions of Eurasia. (3) “Indica type” marijuana, an ancient semi-dwarf cultigen tracing to the Afghanistan-Pakistan area. (4) Semi-dwarf strains of marijuana bred illegally in recent decades to avoid detection when grown clandestinely indoors for the black market. Although the high THC content in marijuana strains limits their usage as germplasm for low-THC cultivars, modern breeding techniques can control this variable. The current elimination of all marijuana germplasm from breeding of hemp cultivars is short-sighted because marijuana biotypes possess a particularly wide range of genes. There is an urgent need to develop public gene bank collections of Cannabis.

The objective was to investigate the effects of heat pretreatment and simulated gastrointestinal digestion on potential antioxidant, anticancer and an…

(2016). Effects of Ethephon on Terpenoids in Cannabis sativa L. in Vegetative Stage. Journal of Essential Oil Bearing Plants: Vol. 19, No. 1, pp. 94-102.

Background The approval of 9-δ-tetrahydocannabinol and cannabidiol (THC:CBD) oromucosal spray (Sativex) for the management of treatment-resistant multiple sclerosis (MS) spasticity opened a new opportunity for many patients. The aim of our study was to describe Sativex effectiveness and adverse events profile in a large population of Italian patients with MS in the daily practice setting. Methods We collected data of all patients starting Sativex between January 2014 and February 2015 from the mandatory Italian medicines agency (AIFA) e-registry. Spasticity assessment by the 0–10 numerical rating scale (NRS) scale is available at baseline, after 1 month of treatment (trial period), and at 3 and 6 months. Results A total of 1615 patients were recruited from 30 MS centres across Italy. After one treatment month (trial period), we found 70.5% of patients reaching a ≥20% improvement (initial response, IR) and 28.2% who had already reached a ≥30% improvement (clinically relevant response, CRR), with a mean NRS score reduction of 22.6% (from 7.5 to 5.8). After a multivariate analysis, we found an increased probability to reach IR at the first month among patients with primary and secondary progressive MS, (n=1169, OR 1.4 95% CI 1.04 to 1.9, p=0.025) and among patients with >8 NRS score at baseline (OR 1.8 95% CI 1.3–2.4 p

Children affected by primary hyperlipidemia have a high risk of developing cardiovascular diseases (CVDs) during adulthood. Several studies have repor…

Cannabis and Cannabinoid Research

Watch the Healing Brain Watch Party here → http://bit.ly/2whtBf4 (airing free through EOD Sun, May 26th, 2019) Discover exactly HOW to use the sacred plant to treat several brain conditions, including Alzheimer's, Dementia, Parkinson's, Stroke, and many more... Go here for all the details → http://bit.ly/2WkMkol Dr. Gerdeman is a neuroscientist and educator with a Ph.D. in Biology. In this expert interview, he speaks of his interest in the endocannabinoid system (ENC) and how it operates within our brain. Watch Dr. Gerdeman translate complex neuroscientific ideas about the ENC into everyday language and hear how he believes our brain has co-evolved with the sacred plant. If you need expert guidance and support with using medical cannabis for a brain disorder, consider our Healing Brain Masterclass. SAVE up to 60% OFF this weekend only → http://bit.ly/2WkMkol