2016

We have already reported that glucosamine (GlcN) distinctly abrogates the pigmentation of human epidermal equivalents stimulated by stem cell factor + endothelin-1 (SE). In this study, we characterized the molecular mechanism involved in the anti-melanogenic effects of GlcN using normal human melanocytes (NHMs) in culture. The SE-stimulated gene (12 h) and protein (24 h) expression levels of melanocyte-specific proteins (at the indicated times post-stimulation) were significantly abrogated by pretreatment with GlcN for 72 h. Western blotting analysis of the phosphorylation of intracellular signaling molecules in the MAPK pathway revealed that despite the significantly decreased level of total CREB protein at all times post-stimulation, the SE-stimulated phosphorylation of ERK, CREB and MITF is not attenuated at 15 min post-stimulation in GlcN-treated NHMs. However, the SE-stimulated protein expression level of total MITF at 2 and 6 h post-stimulation was significantly abrogated by 72 h pretreatment with GlcN. Consistently, pretreatment with GlcN for 72 h abrogated the stimulated gene and protein expression levels of MITF at 1 h and 2 h post-stimulation, respectively. Analysis of gene and protein expression levels also demonstrated that pretreatment with GlcN for 72 h significantly reduced the protein levels of CREB and MITF without affecting their gene expression levels prior to the SE stimulation. Silencing with a CREB siRNA distinctly abrogated the SE-stimulated expression of MITF (at 2 h post-stimulation) and melanocyte-specific proteins (at 24 h post-stimulation). Similarly, transfection of MITF siRNA markedly abrogated the SE-stimulated expression of MITF protein and melanocyte-specific proteins at 2 and 24 h post-stimulation, respectively. Finally, the decreased levels of CREB and MITF proteins induced by 72 h pretreatment with GlcN were abrogated by the co-addition of the proteosomal degradation inhibitor MG132. These findings suggest that the anti-melanogenic effect elicited by GlcN is mediated via the decreased expression of MITF which results from the attenuated transcriptional activity of CREB due to proteolytic degradation.

Quats are disinfectant chemicals commonly found in household cleaners like wipes that are not reducing household illness, but instead can cause harm to our health.

It pains my heart to have to report on what is going on in the world. We all know that being human is not easy, but now we are getting graduate training in how difficult it can be. Most of us can hardly stand to see what is coming. Life is complicated, and as Dr.... View Article

We now can convincingly demonstrate that a ketogenic diet is helpful in Parkinson’s, and we now have a better understanding of the underlying mechanisms.

Countries worldwide have confirmed a staggering number of COVID-19 cases, and it is now clear that no country is immune to the SARS-CoV-2 infection. Resource-poor countries with weaker health systems are struggling with epidemics of their own and are now in a more uncertain situation with this rapidly spreading infection. Frontline healthcare workers are succumbing to the infection in their efforts to save lives. There is an urgency to develop treatments for COVID-19, yet there is limited clinical data on the efficacy of potential drug treatments. Countries worldwide implemented a stay-at-home order to “flatten the curve” and relieve the pressure on the health system, but it is uncertain how this will unfold after the economy reopens. Trehalose, a natural glucose disaccharide, is known to impair viral function through the autophagy system. Here, we propose trehalose as a potential preventative treatment for SARS-CoV-2 infection and transmission.

Dr. Parastoo Azadi discusses the glycobiology of SARS-CoV-2, the virus that causes COVID-19, and how the glycosylation patterns on the virus shed light on vaccine development. Dr. Azadi is the Executive Director of Analytical Services at Complex Carbohydrate Research Center in Georgia, USA.

Hydroxychloroquine was found to be more potent than chloroquine at inhibiting SARS-CoV-2 in vitro. Hydroxychloroquine sulfate 400 mg given twice daily for 1 day

Click here to subscribe - https://www.glutenfreesociety.org/wxrn No matter what you believe about COVID, stress is stress. Due to the stress and the social isolation we have seen a massive influx of folks suffering from headaches in my practice. In this video I go over the different types of headaches and the problem with the way most doctors choose to treat them. To connect with Dr. Osborne visit: On the web: https://drpeterosborne.com/ Facebook: https://www.facebook.com/DoctorPeterOsborne/ Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.

Symptoms, testing, what to do if sick, daily activities, and more.

Sarah King, PT, DPT shows people diagnosed with Parkinson's Disease how to create a personalized Parkinson’s action plan that improves their symptoms, so they can spend less time worrying and more time doing the things they love, with the people they love, for as long as possible.

One does not have to be an anti-vaxxer to see and understand that COVID vaccines are not needed. They are not required legally or for any medical or public health reason to treat or prevent COVID-19. There is a broad range of both natural and pharmaceutical treatments widely available, many already proven to be very... View Article

Science says eating just one meal per day can improve your health. Learn more at https://highintensityhealth.com/OMAD ----- Connect with Bill Curtis: https://www.thefourthfoodgroup.com/ Related Video testing the KetoAid Ketone Ester: https://youtu.be/V-ILObXYsaQ This episode is brought to you by: ➢ Health IQ, an insurance company that helps health conscious people like weightlifters, cyclist, keto dieters and vegetarians get lower rates on their life insurance. ➢ Get a Free Quote: http://healthiq.com/HIH Somnifix.com, the world’s only hypoallergenic mouth tape, developed by Harvard Scientists. https://www.somnifix.com Key Timestamps: 01:55 Journalist Bill Curtis has had Parkinson's since 2000. As predicted, he was dramatically affected 10 years later with advanced Parkinson's. Now the only symptom he has is a slight tremor. 04:48 Within about 2 hours of eating carbs, Bill will begin to shake and feel rigid. He doesn't get the full on symptoms he had before. 07:38 Bill was in an exercise program. In an attempt to enhance the effects of the program, he fasted overnight and had nothing for breakfast before the workout. He found it alleviated his profound fatigue. 11:27 Fasting helped with the fatigue, but there were many more symptoms that were not reversed. Bill continued researching. 13:02 Bill exercised fasted every day for a year. He lost weight, but eventually, it stopped working. As you become fit, you make fewer ketones. 15:04 Dr. Veech suggested that Bill try Bulletproof Coffee after the night fast. Nearly all of his symptoms abated at the end of the first hour. 19:36 The military has been experimenting with Dr. Veech's ketone ester for radiation exposure. 22:26 A therapeutic ketogenic diet is one with 80 to 90% of your food as fat. Bill has devised 4 levels of ketosis. 30:33 Within the first 10 days of taking ketone ester, Bill no longer had urinary incontinence. 32:07 There is data that an elevation of uric acid it will delay the onset of Parkinson's. If you have Parkinson's, and your uric acid levels are higher, you decline more slowly. 36:14 BHB allows you to make more dopamine, serotonin, adrenaline, noradrenaline and nitric oxide. 38:00 In advanced Parkinson's neurotransmitters are negatively impacted. With ketosis, you are making serotonin, noradrenaline, adrenaline, dopamine and nitric oxide synthase. 38:52 Every antioxidant has to be recharged with an electron from NADPH, directly or indirectly. 39:50 Beta hydroxybutyrate raises NADPH levels using isocitrate dehydrogenase in the cytoplasm, outside of the mitochondria. 42:24 NADPH levels in the mitochondria does not correlate with NADPH levels in the cytosol. We should measure the cytosolic NADPH. 44:09 NADPH voltage is dependent upon the relative concentrations. More equals more resilience. 48:52 Dismutase does not get its electrons from the battery. It does this by taking 2 molecules of superoxide, oxidizing one and reducing the other. 52:59 You have the ability to use ketones to restore ischemia-reperfusion and turn off inflammation. 54:08 NADPH controls inflammation. 55:04 Dr. Veech found that treating Alzheimer's mouse models with beta hydroxybutyrate kept them from accumulating beta amyloid deposits. 58:03 Bill believes that TBI will respond very well to BHB, as evidenced by people close to him with head injuries. 01:02:41 Bill has created an online course to help people help each other. You need a cook, a coach, a nutritionist and a doctor. 01:04:36 Bill must still take his Parkinson's medications.

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Nebulizing Magnesium and other natural medicinals as Iodine, Sodium Bicarbonate, peroxide and glutathione are strong treatment options that deliver the medicinals directly to the tracheobronchial tree.

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