2016

The present study was undertaken to evaluate the protective effect of aqueous leaf extract of Aloe vera (ALEAV) in animal model (wistar albino rats) through macroscopic and histopathological study of the colon after inducing ulcerative colitis by usage of acetic acid. 30 healthy albino rats of either sex 150-200g body wt. and 2-4 months age groups were divided into five groups (six in each). Group 1 was normal control group receiving vehicle 1ml of normal saline transrectally (negative control). Group 2 was ulcerative colitis control which was treated with normal saline. Group 3 & 4 were administered aqueous leaf extract of Aloe vera suspension(test drug) 150,300mg/kg bodyweight dose orally for 10 days respectively. Ulcerative colitis was induced on 10 th day. Group 5 was administered prednisolone(1mg/kg) orally for 3 days. On the 3 rd day ulcerative colitis was induced by transrectal administration of 1 ml of 4% acetic acid solution. In all the groups, animals were observed for decrease in bodyweight, stool consistency and rectal bleeding i.e Disease Activity Index for 48 hours after inducing ulcerative colitis. After 48 hours the rats were sacrificed by high dose of ether anaesthesia and a piece of colonic segment(10cm in length) were resected out and subjected to macroscopical study(colon mucosal index) and microscopic evaluation. ALEAV at 150 mg/kg produced significant improvement in macroscopic score in comparison to disease control (group 2) which is comparable to that of normal control (group 1) in ulcerative colitis model. Histopathological studies showed significant dose dependent decrease in lymphoid hyperplasia, neutrophilic infiltration, crypt damage and submucosal inflammation in ALEAV treated group (150 and 300 mg/kg b.w) in comparison to disease control.

Breast cancer is the most common cancer among women and has a high mortality rate. Adverse conditions in the tumor microenvironment, such as hypoxia and acidosis, may exert selective pressure on the tumor, selecting subpopulations of tumor cells with advantages for survival in this environment. In this context, therapeutic agents that can modify these conditions, and consequently the intratumoral heterogeneity need to be explored. Melatonin, in addition to its physiological effects, exhibits important anti-tumor actions which may associate with modification of hypoxia and Warburg effect. In this study, we have evaluated the action of melatonin on tumor growth and tumor metabolism by different markers of hypoxia and glucose metabolism (HIF-1α, glucose transporters GLUT1 and GLUT3 and carbonic anhydrases CA-IX and CA-XII) in triple negative breast cancer model. In an in vitro study, gene and protein expressions of these markers were evaluated by quantitative real-time PCR and immunocytochemistry, respectively. The effects of melatonin were also tested in a MDA-MB-231 xenograft animal model. Results showed that melatonin treatment reduced the viability of MDA-MB-231 cells and tumor growth in Balb/c nude mice (p

Ulcerative colitis is a chronic idiopathic inflammatory bowel disease with a relapsing nature. It is a very challenging disease affecting a patient during the most active period of his life i.e. 20 to 40 years of age. The main features are ano-rectal ...

Thunder Biotech is developing new therapies that help re-educate a patient’s immune system, restoring its ability to recognize and destroy cancer cells.

The tumor growth inhibition and anti-metastatic effects of peach polyphenolics were investigated in vivo using a xenograft model and MDA-MB-435 breast cancer cells. Results showed that tumor growth and lung metastasis were inhibited in vivo by peach polyphenolics in a dose range of 0.8-1.6 mg/day, a …

Our study identifies TFEB as a master regulator of TAMs in breast cancer. TFEB controls TAM gene expression and function through multiple autophagy/lysosome-dependent and independent pathways. Therefore, pharmacological activation of TFEB would be a promising therapeutic approach to improve the effi …

Pages Introduction Dictionary Economic Alternatives Fucose Galactose Glucosamine Glucose Mannose N-Acetylneuraminic Acid Nacetylgalactosamine Sugar

Recent research studies have shown that the intestinal flora are related to the occurrence and progress of breast cancer. This study investigates the effect of fucoidan on intestinal flora and intestinal barrier function in rats with 7,12-dimethylbenz[a]anthracene (DMBA)-induced breast cancers. Sixty female

Europe PMC is an archive of life sciences journal literature.

Fact Boxes can quantify benefits and harms in a clear and accessible format. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ This wraps up my series on mammograms, the rest is up to you. How important are false-positives or overdiagnosis to you? That’s something you have to answer for yourself. To review any of my in-depth mammogram series, here they all are: • 9 out of 10 Women Misinformed about Mammograms ((http://nutritionfacts.org/video/9-out-of-10-Women-misinformed-about-Mammograms) • Mammogram Recommendations - Why the Conflicting Guidelines (http://nutritionfacts.org/video/Mammogram-Recommendations-Why-the-Conflicting-Guidelines) • Should Women Get Mammograms Starting at Age 40? (http://nutritionfacts.org/video/Should-Women-Get-Mammograms-Starting-at-Age-40) • Do Mammograms Save Lives? (http://nutritionfacts.org/video/Do-Mammograms-Save-Lives) • Consequences of False-Positive Mammogram Results (http://nutritionfacts.org/video/Consequences-of-False-Positive-Mammogram-Results) • Do Mammograms Hurt? (http://nutritionfacts.org/video/do-mammograms-hurt) • Can Mammogram Radiation Cause Breast Cancer? (http://nutritionfacts.org/video/Can-Mammogram-radiation-Cause-Breast-Cancer) • Understanding the Mammogram Paradox (http://nutritionfacts.org/video/Understanding-the-Mammogram-Paradox) • Overtreatment of Stage 0 Breast Cancer DCIS (http://nutritionfacts.org/video/overtreatment-of-stage-0-breast-cancer-dcis) • Women Deserve to Know the Truth About Mammograms (http://nutritionfacts.org/video/Women-Deserve-to-Know-the-Truth-About-Mammograms) • Breast Cancer and the 5-Year Survival Rate Myth (http://nutritionfacts.org/video/breast-Cancer-and-the-5-Year-Survival-Rate-Myth) • Why Mammograms Don’t Appear to Save Lives (http://nutritionfacts.org/video/Why-Mammograms-Don) • Why Patients Aren’t Informed About Mammograms (http://nutritionfacts.org/video/why-patients-arent-informed-about-mammograms) I’ve got tons of videos on diet and lifestyle approaches to preventing and treating breast cancer, just stick it in the search bar up top and all will be revealed. Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/the-pros-and-cons-of-mammograms and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/the-pros-and-cons-of-mammograms. You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Captions for this video are available in several languages. To find yours, click on the settings wheel on the lower-right of the video and then "Subtitles/CC." Do you have feedback about the translations in this video? Please share it here along with the title of the video and language: https://nutritionfacts.zendesk.com/hc/requests/new To view the subtitles in transcript format, click on the ellipsis button below the video, choose "Open transcript", and select the language you'd like to view them in. Image credit: Steel Wool / flickr https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

Melatonin, a hormone secreted by pineal gland, exerts antimetastatic effects by reducing tumor cell proliferation, migration and invasion. MicroRNAs (miRNAs) are small, non-coding RNAs that play a crucial role in regulation of gene expression and biological processes of the cells. Herein, we search for a link between the tumor/metastatic-suppressive actions of melatonin and miRNA expression in triple-negative breast cancer cells. We demonstrated that melatonin exerts its anti-tumor actions by reducing proliferation, migration and c-Myc expression of triple negative breast cancer cells. By using Taqman-based assays, we analyzed the expression levels of a set of miRNAs following melatonin treatment of triple negative breast cancer cells and we identified 17 differentially expressed miRNAs, 6 down-regulated and 11 up-regulated. We focused on the anti-metastatic miR-148b and the oncogenic miR-210 both up-regulated by melatonin treatment and studied the effect of their modulation on melatonin-mediated impairment of tumor progression. Surprisingly, when miR-148b or miR-210 were depleted in triple-negative breast cancer cells, using a specific miR-148b sponge or anti-miR-210, melatonin effects on migration inhibition and c-myc downregulation were still visible suggesting that the increase of miR-148b and miR-210 expression observed following melatonin treatment was not required for the efficacy of melatonin action. Nevertheless, ours results suggest that melatonin exhibit a compound for metastatic trait inhibition, especially in MDA-MB-231 breast cancer cells even if a direct link between modulation of expression of certain proteins or miRNAs and melatonin effects has still to be established.

Ginger Improves Symptoms of Ulcerative Colitis, Enhances Quality of Life Bowel and digestive problems like ulcerative colitis can be among the most discomforting and disruptive affronts to a person's lifestyle and overall well-being. What if adding a healthy dose of ginger to your diet could prevent indigestion, inflamed insides and even protect you from colon and rectal cancers? The evidence says, it can

A powerful new Lancet study reveals that the so-called breast cancer susceptibility genes -- BRCA 1 and BRCA 2 -- do not, in fact, cause breast cancer. Jolie's prophylactic mastectomy, for instance, was for naught.

(2018). Therapeutic potential of melatonin for breast cancer radiation therapy patients. International Journal of Radiation Biology: Vol. 94, No. 5, pp. 472-477.

Our results confirm the role of melatonin in the regulation of miR-148a-3p and decrease of angiogenic factors.

GlycoscienceNEWS will provide a glimpse of the GLYCOSCIENCE of tomorrow and how the future of the human race will be enriched in ways only dreamed of before. Here, we will articulate with expectancy where GLYCOSCIENCE can take us today and tomorrow.

The inhibitory effects of trehalose liposomes (TL) comprising l-α-dimyristoylphosphatidylcholine (DMPC) and α-D-glucopyranosyl-α-D-glucopyranoside monomyritate (TreC14) were investigated on breast cancer MDA-MB-453 cells in vitro and in vivo. The IC50 values of TL for MDA-MB-453 cells wer …

You found the Chris Beat Cancer blog! I created this resource to help you heal or prevent cancer holistically. Welcome to the Chris Beat Cancer family!

(2016). Immunomodulatory potential of acemannan (polysaccharide from Aloe vera) against radiation induced mortality in Swiss albino mice. Food and Agricultural Immunology: Vol. 27, No. 1, pp. 72-86.

If doctors don’t understand health statistics how can they possibly counsel patients properly? Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ Many doctors display a similar ignorance about nutrition. See, for example, Physicians May Be Missing their Most Important Tool (https://nutritionfacts.org/video/physicians-may-be-missing-their-most-important-tool/). There’s just one more mammogram video to help you decide: The Pros and Cons of Mammograms (http://nutritionfacts.org/video/The-Pros-and-Cons-of-Mammograms). In case you missed any of the first dozen, check them out: • 9 out of 10 Women Misinformed about Mammograms ((http://nutritionfacts.org/video/9-out-of-10-Women-misinformed-about-Mammograms) • Mammogram Recommendations - Why the Conflicting Guidelines (http://nutritionfacts.org/video/Mammogram-Recommendations-Why-the-Conflicting-Guidelines) • Should Women Get Mammograms Starting at Age 40? (http://nutritionfacts.org/video/Should-Women-Get-Mammograms-Starting-at-Age-40) • Do Mammograms Save Lives? (http://nutritionfacts.org/video/Do-Mammograms-Save-Lives) • Consequences of False-Positive Mammogram Results (http://nutritionfacts.org/video/Consequences-of-False-Positive-Mammogram-Results) • Do Mammograms Hurt? (http://nutritionfacts.org/video/do-mammograms-hurt) • Can Mammogram Radiation Cause Breast Cancer? (http://nutritionfacts.org/video/Can-Mammogram-radiation-Cause-Breast-Cancer) • Understanding the Mammogram Paradox (http://nutritionfacts.org/video/Understanding-the-Mammogram-Paradox) • Overtreatment of Stage 0 Breast Cancer DCIS (http://nutritionfacts.org/video/overtreatment-of-stage-0-breast-cancer-dcis) • Women Deserve to Know the Truth About Mammograms (http://nutritionfacts.org/video/Women-Deserve-to-Know-the-Truth-About-Mammograms) • Breast Cancer and the 5-Year Survival Rate Myth (http://nutritionfacts.org/video/breast-Cancer-and-the-5-Year-Survival-Rate-Myth) • Why Mammograms Don’t Appear to Save Lives (http://nutritionfacts.org/video/Why-Mammograms-Don) Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/why-patients-arent-informed-about-mammograms and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/why-patients-arent-informed-about-mammograms. You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Captions for this video are available in several languages. To find yours, click on the settings wheel on the lower-right of the video and then "Subtitles/CC." Do you have feedback about the translations in this video? Please share it here along with the title of the video and language: https://nutritionfacts.zendesk.com/hc/requests/new To view the subtitles in transcript format, click on the ellipsis button below the video, choose "Open transcript", and select the language you'd like to view them in. Image credit: Jean-François Chénier / flickr https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

camera & edit: http://www.levroi.nl | event information www.TEDxRoermond.nl "These sugars are the missing link in our food and maybe even the missing link in our medicine." Geiske de Ruig explains us about a new science: Glycobiology, the science of sugars. You musn't confuse these essential sugars with the sugars you put in your coffee or tea. These essential sugars are important for cells to communication with each other. Geiske even advocates the relation of our modern diet and shortage of sugars with the rapid growth of health issues. She will convince you to take control over your own health by adjusting your diet. Everyone can start today! About TEDx, x = independently organized event In the spirit of ideas worth spreading, TEDx is a program of local, self-organized events that bring people together to share a TED-like experience. At a TEDx event, TEDTalks video and live speakers combine to spark deep discussion and connection in a small group. These local, self-organized events are branded TEDx, where x = independently organized TED event. The TED Conference provides general guidance for the TEDx program, but individual TEDx events are self-organized.

Millions equate a breast cancer diagnosis with a possible death sentence, doing anything from removing their breasts (and ovaries) with added radiation and chemotherapy treatments, when, in fact, the truth is much more forgiving.

The processed Aloe vera gel (PAG) contains immunomodulatory polysaccharides, which consists of a mixture of polymer chains of b-(1,4)-linked acetylated galactomannan with different lengths. PAG was shown to inhibit azoxymethane(AOM)-initiated and dextran sodium sulfate(DSS)-promoted colon carcinogenesis model in mice. In the present study, we examined the molecular mechanisms for the inhibition of colitis-associated colon carcinogenesis by PAG. PAG administration significantly inhibited the production of pro-inflammatory cytokines and mediators in the colon. Western blot analysis using the colon extracts showed that PAG administration reduced the activation of NF-kB resulting in the inhibition of iNOS and COX-2 expression. PAG appeared to inhibit NF-kB activation through the PPARγ activation. PAG administration also inhibited the expression and phosphorylation of STAT3, which was known to connect inflammation and cancer. PAG administration also inhibited cell cycle progression-related transcription factors such as the proliferating cell nuclear antigen (PCNA), ERK, cyclin-dependent kinase (CDK) 4 and cyclin D1. In contrast, PAG administration increased the expression of CDX2, which was known to be a tumor suppressor in colorectal cancers. These findings show that PAG suppresses colitis-related colon carcinogenesis by inhibiting both chronic inflammation and cell cycle progression in the colon.

After 8 weeks of fecal transplants, some people with tough-to-treat ulcerative colitis had no rectal bleeding or diarrhea, according to a new study. WebMD has the details.

In her talk about sugar and cancer, Stanford Chemistry Professor Carolyn Bertozzi tells us why the sugar coating on our cells is crucial to our health and well-being. Unlike the sugar coating on a peanut M&M, she explains, human cells are covered with complex sugars Bertozzi shows us are, “like foliage swaying in the breeze.” The language these sugars are speaking can tell us everything from what blood type we are to whether we have cancer. Carolyn Bertozzi is the Anne T. and Robert M. Bass Professor of Chemistry and Professor of Chemical & Systems Biology and Radiology (by courtesy) at Stanford, and an investigator of the Howard Hughes Medical Institute. She completed her undergraduate degree at Harvard and her doctorate at UC Berkeley. After postdoctoral work at UCSF and a professorship at UC Berkeley, she joined the faculty at Stanford coincident with the launch of Stanford ChEM-H. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at http://ted.com/tedx