2016

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Brain injury and neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis are urgent medical problems, which severely threaten the life quality of patients and their carers. However, there are currently no effective therapies. Fucoidan is a natural compo

The intestinal microbial communities play critical roles in various aspects of body function of the host. Prebiotics, such as dietary fiber, can affect health of the host by altering the composition of intestinal microbiota. Although brown seaweed Laminaria japonica is rich in dietary fiber, studies on its prebiotic potential are quite rare. In this study, basal diet (control), basal diet supplemented with dried L. japonica (DLJ), heat-treated dried L. japonica (HLJ), or heated dried L. japonica with added fructooligosaccharide (FHLJ) was fed to rats for 16 weeks. Serum concentrations of IgG, triglyceride, and cholesterol were measured. In addition, the intestinal microbiota composition was analyzed by high-throughput sequencing of 16S rRNA gene. As compared to the control group, DLJ, HLJ, and FHLJ groups showed significantly higher serum IgG concentration, but had lower weight gain and serum triglyceride concentration. Moreover, DLJ, HLJ, and FHLJ groups showed lower Fimicutes to Bacteroidetes ratio when compared with the control group. As compared with the control group, obesity-associated bacterial genera (Allobaculum, Turicibacter, Coprobacillus, Mollicute, and Oscilibacter), and the genera with pathogenic potentials (Mollicute, Bacteroides, Clostridium, Escherichia, and Prevotella) decreased while leanness-associated genera (Alistipes, Bacteroides, and Prevotella), and lactic acid bacterial genera (Subdoligranulum, Streptococcus, Lactobacillus, Enterococcus, and Bifid...

Fucoidan, the complex fucose-containing sulphated polysaccharide varies considerably in structure, composition, and bioactivity, depending on the source, species, seasonality, and extraction method. In this study, we examined five fucoidans extracted from the same seaweed species Undaria pinnatifida but from different geological locations, and compared them to the laboratory-grade fucoidan from Sigma (S). The five products differed in molecular composition. The amount of over 2 kDa low molecular weight fraction (LMWF) of the New Zealand crude fucoidan (S1) was larger than that of S, and this fraction was unique, compared to the other four fucoidans. The difference of molecular compositions between S and S1 explained our previous observation that S1 exhibited different anticancer profile in some cancer cell lines, compared with S. Since we observed this unique LMWF, we compared the cytotoxic effects of a LMWF and a high molecular weight fucoidan (HMWF) in two breast cancer cell lines—MCF-7 and MDA-MB-231. Results indicated that the molecular weight is a critical factor in determining the anti-cancer potential of fucoidan, from the New Zealand U. pinnatifida, as the LMWF exhibited a dose-dependent inhibition on the proliferation of breast cancer cells, significantly better than the HMWF, in both cell lines. A time-dependent inhibition was only observed in the MCF-7. Induction of caspase-dependent apoptosis was observed in the MDA-MB-231 cells, through the intrinsic apoptosis pathway alone, or with the extrinsic pathway. LMWF stimulated a dose-dependent NOS activation in the MDA-MB-231 cells. In conclusion, the fucoidan extracted from the New Zealand U. pinnatifida contains a unique LMWF, which could effectively inhibit the growth of breast cancer cell lines. Therefore, the LMWF from New Zealand U. pinnatifida could be used as a supplement cancer treatment.

Malignant glioma (MG) is a poor prognostic brain tumor with inevitable recurrence after multimodality treatment. Searching for more effective treatment is urgently needed. Differentiation induction via epigenetic modification has been proposed as a potential anticancer strategy. Natural products are …

Objective: To determine the activity of fucoidan from Undaria pinnatifida (UPF) and Fucus vesiculosus (FVF) when given in combination of chemotherapy drugs usin...

Objective. To investigate the effect of Laminaria japonica polysaccharides (LJP) on the survival of non-small-cell lung cancer (NSCLC) A549 cells and its mechanism. Methods. In vitro: the cells were randomly divided into control group, LJP (5 mg/ml) group, LJP (10 mg/ml) group, and LJP (20 mg/ml) group. After corresponding treatment, the survival rate and the expression of proteins related to proliferation, apoptosis, epithelial-mesenchymal transition (EMT), and signaling pathway were detected by CCK8 assay and Western blot, respectively. In vivo: a xenograft model was established to detect the tumor volume and mass and the expression of the above pathway proteins. Results. Compared with the control group, LJP decreased the survival rate of A549 cells (), inhibited the protein expression of Ki67 and PCNA (), downregulated the expression of Bcl-2 while upregulated the expression of Bax, cl-caspase-3, and cl-caspase-9 (), upregulated the expression of E-cadherin, downregulated the expression of vascular endothelial growth factor (VEGF) and N-cadherin (), and downregulated β-catenin, transcription factor-4 (TCF4), and c-Myc protein expression levels (). In vivo: LJP decreased the volume and mass of the xenograft tumors and downregulated β-catenin, TCF4, and c-Myc protein expression levels compared with the control group (). Conclusion. LJP can inhibit the survival of non-small-cell lung cancer A549 cells in vitro, and its mechanism is related to the inhibition of activation of β-catenin/TCF4 pathway activation.

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Only Sovereign Laboratories Colostrum LD has been shown to be 1500% more bioavailable. Now with up to 50% more PRP's, colostrum's most powerful component.

Only Sovereign Laboratories Colostrum LD has been shown to be 1500% more bioavailable. Now with up to 50% more PRP's, colostrum's most powerful component.

A groundbreaking new study published in Advances in Mind Body Medicine validates the role of holistic approaches in helping patients successfully withdraw from psychotropic drugs

Reality Check with Ben Swann - http://truthinmedia.com/reality-check-fdas-disinformation-campaign-kratom/ The opioid crisis is killing tens of thousands of Americans each year. So why would the FDA crack down on a substance that may be helping millions of addicts get off drugs like heroin and Oxycontin? This is a Reality Check you won't get anywhere else. Did you remember to subscribe to my YouTube channel? Also follow me here: Facebook - https://www.facebook.com/BenSwannRealityCheck Twitter - https://twitter.com/BenSwann_ Instagram - https://www.instagram.com/BenSwann_/ Newsletter signup - http://truthinmedia.com/newsletter-signup

(2018). Effects of fucoidan on diabetic rat testicular tissue. Biotechnic & Histochemistry: Vol. 93, No. 4, pp. 277-285.

In part I of this series on pain medication side effects, I discuss the common pitfalls of using pain medication for chronic pain problems, including weight gain, nutritional deficiencies, muscle loss, leaky gut problems, and much much more. Make sure you watch part II as well. Subscribe to Dr. Osborne for more natural remedies and functional medicine solutions: Facebook: https://www.facebook.com/DoctorPeterO... Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat disease. He offers nutritional support to people seeking an alternative from traditional

Colorectal cancer (CRC) is one of the major malignancies in humans. This study was designed to evaluate the effects of fucoidan on gut flora and tumor…

Background: Seaweeds represent one of the few remaining food sources available globally which are not being fully utilized or even over utilized. Kelps ( Laminaria spp. ) are one of the numerous species of brown seaweeds, a popular marine vegetable, which has been used as a source of iodine and minerals for centuries. Kelps contain anionic polysaccharides called fucoidans heteroglycans with L – fucose units. Their monosaccharide composition, physicochemical and bioactive properties vary between seaweed species. The objective of this work was to evaluate the bioactive properties of laminaria fucoidan ( L. digitata and L. hyperborea ) toward THP–1 macrophages, a human macrophage like cell line, and investigate its potential antioxidant and immunomodulatory characteristics. Methods: THP-1 macrophages were incubated with five fucoidan concentrations. The Oxygen Radical Absorbance Capacity (ORAC) assay was determined for cell lysates and for the fucoidan extract, in addition to Total Polyphenol Content (TPC). Cytotoxicity of fucoidan was assessed by light microscopy, followed by XTT proliferation assay. Enzyme–linked immunosorbant assays (ELISA) were performed to determine concentrations of the secreted tumor necrosis factor α (TNF-α), interleukin 6 (IL–6), and interleukin 10 (IL–10).   Results: Fucoidan did not affect macrophage ability to scavenge oxygen radicals (ORAC) confirming its antioxidant properties toward activated macrophages. The laminaria fucoidan extract at 100 µg/ml concentration lowered macrophage viability. Lower concentrations of laminaria fucoidan did not have impact on cell viability. Very low concentration of fucoidan at 0.1 µg/ml triggered secretion of TNF-α. However, IL–6 and interleukin IL–10 were expressed when concentration of applied fucoidan was 10 µg/ml indicating bioactivity of laminaria fucoidan through immunomodulatory actions. Conclusions: The study demonstrated how laminaria fucoidan may have bioactive properties towards THP–1 macrophages. Changes in cytokine secretion between pro–inflammatory (TNF–α, and IL–6) and anti–inflammatory (IL–10) cytokines confirmed bioactivity of the laminaria fucoidan extracts. Keywords: Seaweeds, Kelps, Laminaria, fucoidan, bioactivity, macrophages

Does Coffee Cause Autoimmune Disease? The simple answer is, it depends. Research studies have linked coffee consumption to a number of different autoimmune conditions. Type I Diabetes, Hashimoto's Thyroiditis, rheumatoid arthritis, GERD (reflux), and celiac disease are all on the list of diseases that coffee can contribute to. If you have been diagnosed with these conditions, show your doctor this research and ask if coffee is right for you ;) To connect with Dr. Osborne visit: Facebook: https://www.facebook.com/DoctorPeterO... Pinterest: https://www.pinterest.com/docosborne/ Instagram: https://www.instagram.com/drosborne Twitter: https://twitter.com/glutenology *These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Osborne is not a medical doctor. He does not treat or diagnose disease. He offers nutritional support to people seeking an alternative from traditional medicine. Dr. Osborne is licensed with the Pastoral Medical Association.

Preliminary investigation of a fucoidan with demonstrated reduction in the symptoms of osteoarthritis (OA) of the hip and knee.A double-blind randomized controlled trial was carried out to determine the safety and efficacy of a 300 mg dose of a Fucus ...

The effects of ketogenic diets on nutrient sufficiency, gut flora, and heart disease risk. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ There’s just a few videos left in my keto series. Here’s what we have so far: • Is Keto an Effective Cancer-Fighting Diet? (http://nutritionfacts.org/video/is-Keto-an-Effective-Cancer-Fighting-Diet) • Keto Diet Theory Put to the Test (http://nutritionfacts.org/video/keto-diet-theory-put-to-the-test) • Keto Diet Results for Weight Loss (http://nutritionfacts.org/video/Keto-diet-Results-for-Weight-Loss) • Is Weight Loss on Ketosis Sustainable? (http://nutritionfacts.org/video/is-Weight-Loss-on-Ketosis-Sustainable) And here’s what’s coming up: • Keto Diets: Muscle Growth and Bone Density (http://nutritionfacts.org/video/Keto-Diets-Muscle-Growth-and-Bone-Density) • Does a Ketogenic Diet Help Diabetes or Make It Worse? (http://nutritionfacts.org/video/does-a-ketogenic-diet-help-diabetes-or-make-it-worse) The video I mentioned is Gut Dysbiosis: Starving Our Microbial Self (https://nutritionfacts.org/video/gut-dysbiosis-starving-microbial-self). For more on keeping our gut bugs happy see: • Microbiome: The Inside Story (https://nutritionfacts.org/video/microbiome-the-inside-story) • Prebiotics: Tending Our Inner Garden (https://nutritionfacts.org/video/prebiotics-tending-our-inner-garden) • What’s Your Gut Microbiome Enterotype? (https://nutritionfacts.org/video/whats-your-gut-microbiome-enterotype/) • How to Change Your Enterotype (https://nutritionfacts.org/video/how-to-change-your-enterotype/) • Paleopoo: What We Can Learn from Fossilized Feces (http://nutritionfacts.org/video/Paleopoo-What-We-Can-Learn-from-Fossilized-Feces) • Gut Dysbiosis: Starving Our Microbial Self (https://nutritionfacts.org/video/gut-dysbiosis-starving-microbial-self/) • How to Become a Fecal Transplant Super Donor (https://nutritionfacts.org/video/How-to-Become-a-Fecal-Transplant-Super-Donor) • How Our Gut Bacteria Can Use Eggs to Accelerate Cancer (https://nutritionfacts.org/video/How-Our-Gut-Bacteria-Can-Use-Eggs-to-Accelerate-Cancer) • Microbiome: We Are What They Eat (https://nutritionfacts.org/video/Microbiome-We-Are-What-They-Eat) • How to Reduce Your TMAO Levels (http://nutritionfacts.org/video/How-to-Reduce-your-TMAO-Levels) What’s the best diet for our heart? Given that heart disease is the #1 killer of men and women, consider a diet centered around whole plant foods: How Not to Die from Heart Disease (https://nutritionfacts.org/video/how-not-to-die-from-heart-disease/). Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/are-keto-diets-safe and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/are-keto-diets-safe. You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Captions for this video are available in several languages. To find yours, click on the settings wheel on the lower-right of the video and then "Subtitles/CC." Do you have feedback about the translations in this video? Please share it here along with the title of the video and language: https://nutritionfacts.zendesk.com/hc/requests/new To view the subtitles in transcript format, click on the ellipsis button below the video, choose "Open transcript", and select the language you'd like to view them in. Image credit: maglara /adobe stock photos #ketodiet #keto #drgreger https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

In this video, I go over my top 3 tips for following a ketogenic diet safely and effectively. For more info go here: https://drjockers.com/10-critical-ketogenic-diet-tips/

Intermittent Fasting has been shown to reduce whole body inflammation. Discover how intermittent fasting improves brain function.

Water fasting is one of the most ancient and powerful healing strategies known.  Here you will discover what to expect on a 5 day water fast.