2016

Europe PMC is an archive of life sciences journal literature.

The HT-29 human adenocarcinoma cell line has been used extensively in the study of colonic cell differentiation and colon cancer. We report here that substitution of glucose with trehalose (alpha-D-glucopyranosyl-alpha-D-glucopyranoside) depresses growth and promotes mucin-producing, goblet-like mat …

Inappropriate protein aggregation is a key mechanism in the pathogenesis of several neurodegenerative disorders. One of the main strategies by which cells deal with abnormal protein aggregates is autophagy, a degradation pathway for intracellular aggregate-prone proteins. Trehalose, a non-reducing d …

The balance between synthesis and degradation is crucial to maintain cellular homeostasis and different mechanisms are known to keep this balance. In this review, we will provide a short overview on autophagy as an intracellular homeostatic degradative machinery. We will also describe the involvemen …

Gum arabic (GA), a water-soluble dietary fiber rich in Ca2+, Mg2+ and K+, is used in Middle Eastern countries for the treatment of patients with chronic kidney disease. Recent animal experiments shed some light into mechanisms involved in the therapeutic action of GA. According to experiments in healthy mice, GA treatment increases creatinine clear

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates a cluster of oxidative stress-inducible genes in cells. Here, we aimed to investigate whether trehalose (Tr...

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates a cluster of oxidative stress-inducible genes in cells. Here, we aimed to investigate whether trehalose (Tre) protects primary rat proximal tubular (rPT) cells against cadmium (Cd)-induced oxidative stress vi …

Developing effective theranostic nanoplex platforms for personalized disease treatment necessitates an understanding of and the ability to control live cell–nanoparticle interactions. However, aggregation of nanoparticles on the cell surface and their subsequent internalization is sparsely understood and adv

Hyaluronic acid-trehalose is effective and safe, with better patient satisfaction, than existing HA-only eyedrops particularly from the first month of treatment, and offers a therapeutic advancement in the treatment of moderate to severe DED.

Dry eye is a common disorder in routine ophthalmological practice, and a better understanding of the complex pathophysiology is leading to improved treatment. Thealoz Duo(®) is a novel artificial tear preparation containing two active ingredients: Trehalose, a naturally occurring disaccharide with a …

Acacia gum is a branched complex polysaccharide whose main chain consists of 1,3-linked β-D-galactopyranosyl units. Acacia gum is defined as a heteropolysaccharide since it contains ∼2% of a polypeptide. The major molecular fraction (F1) ...

Aloe vera, a succulent perennial and drought resisting plant, is well known for its therapeutic potential. A number of beneficial effects of Aloe vera…

This work aimed to determine the effect of homogenization pressures and addition of trehalose on the functional properties of mandarin juice enriched …

Browse the archive of articles on Nature Reviews Cardiology

Objective: To assess the safety and efficacy of weekly IV administration of Cabaletta (trehalose 9\[percnt] solution) in OPMD after a 24 week open label phase 2 trial. Background: Trehalose showed efficacy in reducing PABPN1 muscle aggregation and improving muscle function in a transgenic OPMD mouse model. Methods:25 genetically-confirmed OPMD patients received weekly infusion of 300 cc Cabaletta. Swallowing, muscle power and functional tests, and swallowing quality of life report (SWAL-QOL) were assessed at baseline and after 24 weeks. Results: No serious drug-related adverse effects were noted. Time to swallow 80cc cold water (an OPMD validated dysphagia test) improved by 35.3[percnt\] (p

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Study of Antioxidant and Anti-Inflammatory Crude Methanol Extract and Fractions of Acacia seyal Gum, Ahmed AM Elnour,Mohamed ES Mirghani,Kabbashi NA, Md Al

BACKGROUND: The use of herbal and synthetic compounds can be effective in improving the areas and repair of tissues that have been affected during the processes like what happens in ulcerative colitis (UC) as a common inflammatory disorder. According to the beneficial effects of aloe vera, in this study, we aimed to assess the therapeutic effects of oral aloe vera gel on acetic acid-induced colitis in rats by histopathological and molecular analysis of Bax, and BCL-2 genes expression (using RT-PCR technique) in colon tissue samples. METHODS: This experimental study comprised 32 adult male Sprague Dawley rats weighting  220±20 g that were randomly divided into four groups as follows. The control group (healthy rats), colitis group in which UC was induced by transrectal administration of 3% acetic acid with no treatment, oral form of sulfasalazine group in which UC was induced by transrectal administration of 3% acetic acid, then was treated by oral administration of sulfasalazine 500 mg/kg body weight, and the fourth group which received oral form of aloe vera gel (200 mg/kg) for 21 days, respectively after induction of UC. Then, the therapeutic effects of treatment groups were compared with the control group and the colitis group with no treatment, by the assessment of histopathological and molecular changes in the colon tissues of rats on the 7 th , 14 th , and 21 st days. Finally, the collected data were analyzed using statistical tests. RESULTS: Histologically, aloe vera gel treatment could reduce and heal colon tissue damages in induced colitis. Also, this gel reduced apoptosis in rat’s colon with acetic acid-induced colitis, which showed in significantly decreased in Bax mRNA expression and significantly increased BCL-2 mRNA expression compared with the colitis group with no treatment. CONCLUSION:  Aloe vera gel has a significant effect on the treatment of UC in rat because of the beneficial effect that was found from aloe vera such as decreasing the severity of colitis as evidenced by histopathological findings, and with respect to apoptosis and gene expression that were related to wound healing process, and suppression of the elevation of Bax mRNA with the upregulation of Bcl-2, which can be considered effective in the treatment of UC.

This article reports the results of a within-subject design. Fifty subjects with a physician diagnosis of fibromyalgia (FM) and/or chronic fatigue syndrome (CFS) were interviewed using a structured interview from. Each subject was interviewed initially, and again nine months later (follow-up). Subje …

What does clinical course of COVID-19 look like for both those who survive and those who don’t? How the symptoms compare to the flu. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ This is the 7th in a 17-video series on pandemics and COVID-19. If you’ve already seen these videos as part of my two webinars, or already watched the digital download (https://drgreger.org/collections/downloads/products/how-to-survive-a-pandemic-digital), keep your eyes out on Fridays as we continue our Flashback Friday series, and explore the many topics we have here on NutritionFacts.org (https://nutritionfacts.org/topics/). Here are the first six: · Where Do Deadly Coronaviruses Like MERS-CoV Come From? (http://nutritionfacts.org/video/where-do-deadly-coronaviruses-like-mers-cov-come-from) · The SARS Coronavirus and Wet Markets (http://nutritionfacts.org/video/the-sars-coronavirus-and-wet-markets) · Where Did the COVID-19 Coronavirus Come From? (http://nutritionfacts.org/video/where-did-the-covid-19-coronavirus-come-from) · The Last Coronavirus Pandemic May Have Been Caused by Livestock (http://nutritionfacts.org/video/the-last-coronavirus-pandemic-may-have-been-caused-by-livestock) · R0 and Incubation Periods: How Other Coronavirus Outbreaks Were Stopped (http://nutritionfacts.org/video/r0-and-incubation-periods-how-other-coronavirus-outbreaks-were-stopped) · Social Distancing, Lockdowns & Testing: How to Slow the COVID-19 Pandemic (http://nutritionfacts.org/video/social-distancing-lockdowns-testing-how-to-slow-the-covid-19-pandemic) Stay tuned for: · Modifiable Risk Factors and Comorbidities for Severe COVID-19 Infection (http://nutritionfacts.org/video/modifiable-risk-factors-and-comorbidities-for-severe-covid-19-infection) · The Immune System and COVID-19 Treatment (http://nutritionfacts.org/video/the-immune-system-and-covid-19-treatment) · Would Zinc Lozenges Help with COVID-19? (http://nutritionfacts.org/video/would-zinc-lozenges-help-with-covid-19) · How to Avoid COVID-19 (http://nutritionfacts.org/video/how-to-avoid-covid-19) · Hand Washing & Sanitizing to Inactivate COVID-19 Coronavirus (http://nutritionfacts.org/video/hand-washing-sanitizing-to-inactivate-covid-19-coronavirus) · What to Do if You Come Down with COVID-19 (http://nutritionfacts.org/video/what-to-do-if-you-come-down-with-covid-19) · The Best Mask or DIY Face Covering for COVID-19 (http://nutritionfacts.org/video/the-best-mask-or-diy-face-covering-for-covid-19) · How COVID-19 Ends: Vaccination, Mutations, and Herd Immunity (http://nutritionfacts.org/video/how-covid-19-ends-vaccination-mutations-and-herd-immunity) · The COVID-19 Pandemic May Just Be a Dress Rehearsal (http://nutritionfacts.org/video/the-covid-19-pandemic-may-just-be-a-dress-rehearsal) · How to Prevent the Next Pandemic (http://nutritionfacts.org/video/how-to-prevent-the-next-pandemic) You can download the whole series (for free) right now at https://drgreger.org/collections/downloads/products/how-to-survive-a-pandemic-digital and take an even deeper dive in my new book How to Survive a Pandemic (https://nutritionfacts.org/how-to-survive-a-pandemic/) (note: all my proceeds from this book are donated to pandemic prevention charities). Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/covid-19-symptoms-vs-the-flu-a-cold-or-allergies and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at https://nutritionfacts.org/video/covid-19-symptoms-vs-the-flu-a-cold-or-allergies. You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Captions for this video are available in several languages; you can find yours in the video settings. Image credit: annaj / pixabay https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • How to Survive a Pandemic: https://nutritionfacts.org/how-to-survive-a-pandemic • How Not to Die: https://nutritionfacts.org/book • How Not to Diet: https://nutritionfacts.org/how-not-to-diet • Facebook: www.facebook.com/NutritionFacts.org

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