2016

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates a cluster of oxidative stress-inducible genes in cells. Here, we aimed to investigate whether trehalose (Tre) protects primary rat proximal tubular (rPT) cells against cadmium (Cd)-induced oxidative stress vi …

Hyaluronic acid-trehalose is effective and safe, with better patient satisfaction, than existing HA-only eyedrops particularly from the first month of treatment, and offers a therapeutic advancement in the treatment of moderate to severe DED.

Dry eye is a common disorder in routine ophthalmological practice, and a better understanding of the complex pathophysiology is leading to improved treatment. Thealoz Duo(®) is a novel artificial tear preparation containing two active ingredients: Trehalose, a naturally occurring disaccharide with a …

Europe PMC is an archive of life sciences journal literature.

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates a cluster of oxidative stress-inducible genes in cells. Here, we aimed to investigate whether trehalose (Tr...

Support Your Digestive System with Aloe Vera By Jamie Rutherford 2/3/2017 For Global Healing Center Support Your Digestive System with Aloe Vera A properly functioning digestive system is the found…

• Aloe's prebiotic effects are fantastic due to the chemical structure of some of its components. Surprisingly the aloe vera gel is about 55% polysaccharides and contains a compound called acemannan.

The balance between synthesis and degradation is crucial to maintain cellular homeostasis and different mechanisms are known to keep this balance. In this review, we will provide a short overview on autophagy as an intracellular homeostatic degradative machinery. We will also describe the involvemen …

Background There is a strong association between cardiometabolic risk and adipose tissue dysfunction with great consequences on type 2 diabetic patients. Visceral Adiposity Index (VAI) is an indirect clinical marker of adipose tissue dysfunction. Gum Arabic (GA) is a safe dietary fiber, an exudate of Acacia Senegal. Gum Arabic had shown lipid lowering effect in both humans and animals. The aim of this trial was to determine the effect of GA supplementation on anthropometric obesity marker, Visceral Adiposity Index (VAI) and blood pressure in patients with type 2 diabetes mellitus. Methods This randomized, double blinded, placebo controlled trial recruited a total of 91 type 2 diabetic patients (73 females, 18 males), age (mean ± SD) 50.09 ± 9.3 years on hypoglycemic agents and were randomly assigned into two groups, either to consume 30 g of GA or 5 g of placebo daily for 3 months. Anthropometric obesity markers were measured and indices were calculated. Blood pressure was measured and high density lipoprotein (HDL) and triglycerides (TG) were determined in fasting blood samples at the start and end of the study period. Results After intervention, Gum Arabic decreased BMI and VAI significantly (P

Current evidence indicates an immunostimulating role for complex carbohydrates, i.e., polysaccharides, from several plant sources. In the present work, we determined the specific in vivo effects, with time of administration, of one such compound, a neutral arabinogalactan from larch not only on immu …

The Journal of Alternative and Complementary Medicine

Background: Chondroitin sulfate proteoglycans (CSPGs) are the major cause of axonal regeneration failure at the site of lesion in spinal cord injury (SCI). Inflammation is believed to stimulate the upregulation of CSPGs expression. Recent evidence showed that trehalose reduces the development of inflammation in SCI. The aim of this study was to investigate the effect of trehalose on neurocan and Neural-Glial Antigen 2 (NG2) mRNA levels in SCI in rats. Methods: In this experimental study, male rats were divided into six groups (n=15). Sham (laminectomy), SCI (laminectomy and SCI), vehicle (laminectomy and SCI, treated with phosphate buffer saline), and T10, T100 and T1000 (laminectomy and SCI, treated with 10, 100 and 1000 mM trehalose). Five rats in each group were sacrificed at 1, 3 and 7 days post-injury to measure neurocan and NG2 mRNA levels in lesion. Statistical analysis was performed using Kruskal-Wallis methods followed by the Mann-Whitney test. Results: Findings indicated that SCI upregulated neurocan and NG2 mRNA levels at all times. No significant difference was observed in neurocan and NG2 gene transcripts between SCI and vehicle groups (p>0.05). However, 10 mM trehalose downregulated the mRNA level of both neurocan (0.76 and 0.65 fold) and NG2 (0.75 and 0.70 fold) at 3 and 7 days post-SCI compared to vehicle group (p p

Scar preventive dextran based bionanocomposite dressings containing aloe vera (AV) and manuka honey (MH) were developed as wound care devices. This wo…

Abstract Biogenic synthesis of silver nanoparticles (AgNP) was performed at room temperature using Aloe vera plant extract in the presence of ammoniacal silver nitrate as a metal salt precursor. The formation of AgNP was monitored by UV-visible spectroscopy at different time intervals. The shape and size of the synthesized particle were visualized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) observations. These results were confirmed by X-ray powder diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) analyses and further supported by surface-enhanced Raman spectroscopy/Raman scattering (SERS) study. UV-visible spectrum has shown a sharp peak at 420 nm and further evidenced by FTIR peak profile (at 1587.6, 1386.4, and 1076 cm−1 with corresponding compounds). The main band position with SERS was noticed at 1594 cm−1 (C–C stretching vibration). When samples were heated under microwave radiation, AgNP with octahedron shapes with 5–50 nm were found and this method can be one of the easier ways to synthesis anisotropic AgNP, in which the plant extract plays a vital role to regulate the size and shape of the nanoparticles. Enhanced antibacterial effects (two- to fourfold) were observed in the case of Aloe vera plant protected AgNP than the routinely synthesized antibiotic drugs. Graphical Abstract Shape and size-controlled synthesis of silver nanoparticles using Aloe vera plant extract

This study sought to improve the handling, stability to aqueous medium and healing properties of alginate-based three-dimensional structures to be app…

What does clinical course of COVID-19 look like for both those who survive and those who don’t? How the symptoms compare to the flu. Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ This is the 7th in a 17-video series on pandemics and COVID-19. If you’ve already seen these videos as part of my two webinars, or already watched the digital download (https://drgreger.org/collections/downloads/products/how-to-survive-a-pandemic-digital), keep your eyes out on Fridays as we continue our Flashback Friday series, and explore the many topics we have here on NutritionFacts.org (https://nutritionfacts.org/topics/). Here are the first six: · Where Do Deadly Coronaviruses Like MERS-CoV Come From? (http://nutritionfacts.org/video/where-do-deadly-coronaviruses-like-mers-cov-come-from) · The SARS Coronavirus and Wet Markets (http://nutritionfacts.org/video/the-sars-coronavirus-and-wet-markets) · Where Did the COVID-19 Coronavirus Come From? (http://nutritionfacts.org/video/where-did-the-covid-19-coronavirus-come-from) · The Last Coronavirus Pandemic May Have Been Caused by Livestock (http://nutritionfacts.org/video/the-last-coronavirus-pandemic-may-have-been-caused-by-livestock) · R0 and Incubation Periods: How Other Coronavirus Outbreaks Were Stopped (http://nutritionfacts.org/video/r0-and-incubation-periods-how-other-coronavirus-outbreaks-were-stopped) · Social Distancing, Lockdowns & Testing: How to Slow the COVID-19 Pandemic (http://nutritionfacts.org/video/social-distancing-lockdowns-testing-how-to-slow-the-covid-19-pandemic) Stay tuned for: · Modifiable Risk Factors and Comorbidities for Severe COVID-19 Infection (http://nutritionfacts.org/video/modifiable-risk-factors-and-comorbidities-for-severe-covid-19-infection) · The Immune System and COVID-19 Treatment (http://nutritionfacts.org/video/the-immune-system-and-covid-19-treatment) · Would Zinc Lozenges Help with COVID-19? (http://nutritionfacts.org/video/would-zinc-lozenges-help-with-covid-19) · How to Avoid COVID-19 (http://nutritionfacts.org/video/how-to-avoid-covid-19) · Hand Washing & Sanitizing to Inactivate COVID-19 Coronavirus (http://nutritionfacts.org/video/hand-washing-sanitizing-to-inactivate-covid-19-coronavirus) · What to Do if You Come Down with COVID-19 (http://nutritionfacts.org/video/what-to-do-if-you-come-down-with-covid-19) · The Best Mask or DIY Face Covering for COVID-19 (http://nutritionfacts.org/video/the-best-mask-or-diy-face-covering-for-covid-19) · How COVID-19 Ends: Vaccination, Mutations, and Herd Immunity (http://nutritionfacts.org/video/how-covid-19-ends-vaccination-mutations-and-herd-immunity) · The COVID-19 Pandemic May Just Be a Dress Rehearsal (http://nutritionfacts.org/video/the-covid-19-pandemic-may-just-be-a-dress-rehearsal) · How to Prevent the Next Pandemic (http://nutritionfacts.org/video/how-to-prevent-the-next-pandemic) You can download the whole series (for free) right now at https://drgreger.org/collections/downloads/products/how-to-survive-a-pandemic-digital and take an even deeper dive in my new book How to Survive a Pandemic (https://nutritionfacts.org/how-to-survive-a-pandemic/) (note: all my proceeds from this book are donated to pandemic prevention charities). Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/covid-19-symptoms-vs-the-flu-a-cold-or-allergies and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at https://nutritionfacts.org/video/covid-19-symptoms-vs-the-flu-a-cold-or-allergies. You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Captions for this video are available in several languages; you can find yours in the video settings. Image credit: annaj / pixabay https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • How to Survive a Pandemic: https://nutritionfacts.org/how-to-survive-a-pandemic • How Not to Die: https://nutritionfacts.org/book • How Not to Diet: https://nutritionfacts.org/how-not-to-diet • Facebook: www.facebook.com/NutritionFacts.org

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