2016

Kidney disease is a silent killer. It is dangerous because it usually recognized at extremely late stages. Sodium bicarbonate, magnesium, marijuana and infrared therapies are the most effective kidney medicines.

The greedy metabolism of cancer cells to target kidney cell carcinomas, which kill more than 100,000 Americans each year, has been exploited by researchers. The team showed that the majority of renal cell cancers rewire their metabolism in a way that leaves them addicted to the nutrient cystine. By depriving the cancer cells of cystine, the researchers were able to trigger a form of cell death called necrosis in tumor cells.

Autophagy impairment has been demonstrated in the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD) and could be a new target of treatment. Trehalose is a natural, nonreducing disaccharide that has been shown to enhance autophagy. Therefore, we investigated whether trehalose treatment reduces renal cyst formation in a Pkd1-hypomorphic mouse model. Pkd1 miRNA transgenic (Pkd1 miR Tg) mice and wild-type littermates were given drinking water supplemented with 2% trehalose from postnatal day 35 to postnatal day 91. The control groups received pure water or 2% sucrose for the control of hyperosmolarity. The effect on kidney weights, cystic indices, renal function, cell proliferation, and autophagic activities was determined. We found that Pkd1 miR Tg mice had a significantly lower renal mRNA expression of autophagy-related genes, including atg5, atg12, ulk1, beclin1, and p62, compared with wild-type control mice. Furthermore, immunohistochemical analysis showed that cystic lining cells had strong positive staining for the p62 protein, indicating impaired degradation of the protein by the autophagy-lysosome pathway. However, trehalose treatment did not improve reduced autophagy activities, nor did it reduce relative kidney weights, plasma blood urea nitrogen levels, or cystatin C levels in Pkd1 miR Tg mice. Histomorphological analysis revealed no significant differences in the renal cyst index, fibrosis score, or proliferative score among trehalose-, sucrose-, and water-treated groups. Our results demonstrate that adding trehalose to drinking water does not modulate autophagy activities and renal cystogenesis in Pkd1-deficient mice, suggesting that an oral supplement of trehalose may not affect the progression of ADPKD.

IN BRIEF For the goals of reducing diabetic kidney disease (DKD) onset and progression, approaches to nutritional therapy are a subject of much debate. This article discusses selected nutrients that have a role in affecting DKD outcomes and introduces application of newer, individualized concepts for healthful eating, as supported by clinical evidence relevant to patients with DKD. Selected aspects of management of advanced DKD are also reviewed.

Tubulointerstitial fibrosis is recognized as a key determinant of progressive chronic kidney disease (CKD). Fucoidan, a sulphated polysaccharide extracted from brown seaweed, exerts beneficial effects in some nephropathy models. The present study evaluated ...

To investigate the protective effect of extracts prepared from avocado, walnut, flaxseed and Eruca sativa seeds in a rat model of kidney dysfunction induced by intraperitoneal cisplatin.Ethanol and petroleum ether extracts mixture was prepared from each ...

ReferenceLazarus B, Chen Y, Wilson F, et al. Proton pump inhibitor use and the risk of chronic kidney disease. JAMA Intern Med. 2016;176(2):238-246.Study ObjectiveTo assess a potential correlation between proton pump inhibitor (PPI) use and incidence of chronic kidney disease (CKD). DesignObservational study tracking glomerular filtration rate (GFR) of PPI users compared to nonusers. ParticipantsThe study included 10,482 subjects participating in the Atherosclerosis Risk in Communities (ARIC) study. All subjects had a baseline GFR greater than 60 mL/min/1.73 m2.

We explored whether the combination of anti-oxidant and anti-inflammatory guava (Psidium guajava) and trehalose treatment protects the kidney and pancreas against Type II diabetes (T2DM)-induced injury in rats. We measured the active component of guava juice by HPLC analysis. T2DM was induced in Wis …

Gum arabic (GA), a water-soluble dietary fiber rich in Ca(2+), Mg(2+) and K(+), is used in Middle Eastern countries for the treatment of patients with chronic kidney disease. Recent animal experiments shed some light into mechanisms involved in the therapeutic action of GA. According to experiments …

Gum arabic (GA), a water-soluble dietary fiber rich in Ca2+, Mg2+ and K+, is used in Middle Eastern countries for the treatment of patients with chronic kidney disease. Recent animal experiments shed some light into mechanisms involved in the therapeutic action of GA. According to experiments in healthy mice, GA treatment increases creatinine clear

Diabetic kidney disease is the most common cause of end-stage kidney disease and poses a major global health problem. Finding new, safe, and practical strategies to halt this disease has proven to be challenging for mainstream medicine because their aversion to natural medicine prevents them from understanding the underlying causes. In this essay, we will... View Article

Diabetes is the leading cause of kidney failure, and scientists have found that infusing just a small dose of a cytokine, thought to help cause that failure, can instead prevent or reverse it.

Sodium Bicarbonate (NaHCO3) commonly called baking soda is a natural substance used in the human body within the bloodstream to regulate pH as a counterbalance to acid build up. Bicarbonate affects the pH of cells and tissues, balances cell voltage, and increases CO2 which helps with oxygenation.

Diabetic kidney disease, diagnosed by urinary albumin excretion rate (AER), is a critical symptom of chronic vascular injury in diabetes, and is associated with dyslipidemia and increased mortality. We investigated serum lipids in 326 subjects with type 1 diabetes: 56% of patients had normal AER, 17% had microalbuminuria (20 ≤ AER < 200 μg/min or 30 ≤ AER < 300 mg/24 h) and 26% had overt kidney disease (macroalbuminuria AER ≥ 200 μg/min or AER ≥ 300 mg/24 h). Lipoprotein subclass lipids and low-molecular-weight metabolites were quantified from native serum, and individual lipid species from the lipid extract of the native sample, using a proton NMR metabonomics platform. Sphingomyelin (odds ratio 2.53, P < 10−7), large VLDL cholesterol (odds ratio 2.36, P < 10−10), total triglycerides (odds ratio 1.88, P < 10−6), omega-9 and saturated fatty acids (odds ratio 1.82, P < 10−5), glucose disposal rate (odds ratio 0.44, P < 10−9), large HDL cholesterol (odds ratio 0.39, P < 10−9) and glomerular filtration rate (odds ratio 0.19, P < 10−10) were associated with kidney disease. No associations were found for polyunsaturated fatty acids or phospholipids. Sphingomyelin was a significant regressor of urinary albumin (P < 0.0001) in multivariate analysis with kidney function, glycemic control, body mass, blood pressure, triglycerides and HDL cholesterol. Kidney injury, sphingolipids and excess fatty acids have been linked in animal models—our exploratory approach provides independent support for this relationship in human patients with diabetes.

Chronic kidney disease (CKD) is a globally common and important disease and there are evidence for a bidirectional relationship between microbiota and…

Chronic kidney disease results in disruption of the intestinal epithelial barrier as well as profound changes in the gut microbial flora. These events…

Plant-based diets have been successfully shown to slow or stop the progression of kidney failure, but what about all the phosphorus and potassium in plant foods? Subscribe to NutritionFacts.org’s free newsletter to receive our B12 infographic that covers the latest research takeaways and Dr. Greger’s updated recommendations: https://nutritionfacts.org/subscribe/ This is the last of an extended six-part video series on the latest science on diet and kidney health. Check out the rest of the series here: • Preventing Kidney Failure Through Diet (http://nutritionfacts.org/video/preventing-kidney-failure-through-diet/) • Treating Kidney Failure Through Diet (http://nutritionfacts.org/video/treating-kidney-failure-through-diet/) • Can Diet Protect Against Kidney Cancer? (http://nutritionfacts.org/video/can-diet-protect-against-kidney-cancer/) • Which Type of Protein is Better for Our Kidneys? (http://nutritionfacts.org/video/which-type-of-protein-is-better-for-our-kidneys/) • Protein Source: An Acid Test for Kidney Function (http://nutritionfacts.org/video/protein-source-an-acid-test-for-kidney-function) The problem for most people (98% of American Diets Potassium Deficient http://nutritionfacts.org/video/98-of-american-diets-potassium-deficient/) is not getting enough potassium, but you have to have functioning kidneys to keep you in balance. Too much phosphorus in the blood can also be a problem. Phosphate additives are something we should try to stay away from. See my three-part video series: • Phosphate Additives in Meat Purge and Cola (http://nutritionfacts.org/video/phosphate-additives-in-meat-purge-and-cola/) • Phosphate Additives in Chicken (http://nutritionfacts.org/video/phosphate-additives-in-chicken/) • How to Avoid Phosphate Additives (http://nutritionfacts.org/video/how-to-avoid-phosphate-additives/) Have a question for Dr. Greger about this video? Leave it in the comment section at http://nutritionfacts.org/video/treating-chronic-kidney-disease-with-food and he'll try to answer it! Image Credit: Steve Davis via Flickr. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books (including the NEW How Not to Diet Cookbook): https://nutritionfacts.org/books • Shop: https://drgreger.org

The most overlooked aspect of the coronavirus pandemic is the fact that most viruses are pH sensitive. pH medicine offers us a key to treating viral infections that is easy, safe and inexpensive. Shifting a patients pH, combined with high dosages of vitamin C, is the appropriate foundation treatments for at home and hospital care.... View Article

You don't want to miss this excellent footage of a conversation between some young Mormons and Jeff Durbin and Zach Conover from Apologia Church. This is actual footage from our annual Mormon Temple outreach at the Mesa Temple's Easter Pageant. The conversation centers around the grace of God and salvation. Mormonism teaches that people are saved through a combination of grace, faith, and works. This is an antithetical message to the Gospel found in Scripture (Romans 1-5). This is a powerful conversation. God has used these videos to lead many, many Mormons to saving faith in the true Christ. We humbly encourage you to Like and Share this video. These works as excellent "Gospel tracts". Get more content and learn how to witness to Mormons by signing up for All Access at http://apologiastudios.com.

Don't miss this important message delivered by Jeff Durbin at a conference on Christian Apologetics. Jeff Durbin, of Apologia Church/Radio/TV, spoke on how to engage our Mormon friends, family, and neighbors. Was Joseph Smith Jr. a prophet sent from God? Is Mormonism a Christian religion? What does Mormonism truly teach about God? How do we reach Mormons in love with the truth of the Gospel? Want more help defending the Christian faith? Go to https://apologiaradio.com and sign-up for our All Access. When you partner with us you get access to all of our TV shows, our After Shows, and Apologia Academy in which you can learn about the Biblical Worldview and defending the Faith by teachers like, Dr. James White, Jeff Durbin, R.C. Sproul Jr., Douglas Wilson, Dr. K Scott Oliphint, John Samson, and more! Don't forget to subscribe to our channel for more great content and don't forget to share this message with someone you love!

John 5:17-24 The Master's Seminary - http://www.tms.edu/ Theological Resources - http://www.theologicalresources.org/

E-Books: https://tinyurl.com/y3wbhlxy Traditional Books: https://tinyurl.com/y4xgz9rb Audio CDs: https://tinyurl.com/y5nnj3eu For more of Dr. John Barnett's Bible teaching messages go to DiscoverTheBook.org From WFM-13 (011007AM)

Joseph Smith made his own translation of the Bible and added quite a lot of new and interesting content to the original, including prophecy about Joseph Smith! Links: What you need to know about how we got the Bible - https://www.youtube.com/watch?v=WclIZwBFhq0&index=1&list=PLZ3iRMLYFlHuzJhPtmrgqpVoXhjvqiIjW My recent End Times debate on Matthew 24 - https://youtu.be/8KhVI2gD22w